scholarly journals Pseudotumor Cerebri Syndrome as a Neurologic Involvement of Multisystem Inflammatory Syndrome in Children: A Case Report

2021 ◽  
Vol 67 (4) ◽  
Author(s):  
Ayşe İrem Sofuoğlu ◽  
Nihal Akçay ◽  
Esra Şevketoğlu ◽  
Gonca Bektaş
Keyword(s):  
Brain Magnetic Resonance Imaging ◽  
Pseudotumor Cerebri ◽  
Immunoglobulin M ◽  
Disturbance Of Consciousness ◽  
Pseudotumor Cerebri Syndrome ◽  
Abducens Paralysis ◽  
Grade 3 ◽  
Inflammatory Syndrome ◽  
Possible Cause ◽  
Post Infectious

Abstract Background Coronavirus disease 2019 may have neurological manifestations including meningitis, encephalitis, post-infectious brainstem encephalitis and Guillain-Barre syndrome. Neuroinflammation has been claimed as a possible cause. Here, we present a child with multisystem inflammatory syndrome in children (MIS-C) who developed pseudotumor cerebri syndrome (PTCS) during the disease course. Case A 11-year-old girl presented with 5 days of fever, headache and developed disturbance of consciousness, respiratory distress, conjunctivitis and diffuse rash on her trunk. Immunoglobulin M and G antibodies against severe acute respiratory syndrome coronavirus 2 were positive in her serum. She was diagnosed with MIS-C. On day 10, she developed headache and diplopia. Left abducens paralysis and bilateral grade 3 papilledema were observed. Brain magnetic resonance imaging revealed optic nerve head protrusion, globe flattening. She was diagnosed with secondary PTCS. Papilledema and abducens paralysis improved under acetazolamide and topiramate. Neurological examination became normal after 2 months. Conclusion PTCS may emerge related to MIS-C.

COVID-19-associated multisystem inflammatory syndrome in children presenting uniquely with sinus node dysfunction in the setting of shock

2021 ◽  
pp. 1-3
Author(s):  
Lesya G. Tomlinson ◽  
Mitchell I. Cohen ◽  
Rebecca E. Levorson ◽  
Megan B. Tzeng
Keyword(s):  
Inflammatory Process ◽  
Myocardial Dysfunction ◽  
Sinus Node ◽  
Qtc Prolongation ◽  
Mild Disease ◽  
Abnormal Immune Response ◽  
Idioventricular Rhythm ◽  
Inflammatory Syndrome ◽  
Electrocardiographic Abnormalities ◽  
Post Infectious

Abstract SARS-CoV-2, which causes the disease COVID-19, generally has a mild disease course in children. However, a severe post-infectious inflammatory process known as multisystem inflammatory syndrome in children has been observed in association with COVID-19. This inflammatory process is a result of an abnormal immune response with similar clinical features to Kawasaki disease. It is well established that multisystem inflammatory syndrome in children is associated with myocardial dysfunction, coronary artery dilation or aneurysms, and occasionally arrhythmias. The most common electrocardiographic abnormalities seen include premature atrial or ventricular ectopy, variable degrees of atrioventricular block, and QTc prolongation, and rarely, haemodynamically significant arrhythmias necessitating extracorporeal membrane oxygenation support. However, presentation with fever, hypotension, and relative bradycardia with a left axis idioventricular rhythm has not been previously reported. We present a case of a young adolescent with multisystem inflammatory syndrome in children with myocarditis and a profoundly inappropriate sinus node response to shock with complete resolution following intravenous immunoglobulin.

Pseudotumor cerebri syndrome in a patient with narcolepsy type 1

2018 ◽  
Vol 22 (1) ◽  
pp. 194-198 ◽  
Author(s):  
Thomas Rossor ◽  
Ming Lim ◽  
Kirandeep VanDenEshof ◽  
Paul Gringras
Keyword(s):  
Pseudotumor Cerebri ◽  
Pseudotumor Cerebri Syndrome

Pseudotumor cerebri syndrome: venous sinus obstruction and its treatment with stent placement

2003 ◽  
Vol 98 (5) ◽  
pp. 1045-1055 ◽  
Author(s):  
Brian K. Owler ◽  
Geoffrey Parker ◽  
G. Michael Halmagyi ◽  
Victoria G. Dunne ◽  
Verity Grinnell ◽  
...  
Keyword(s):  
Stent Placement ◽  
Pseudotumor Cerebri ◽  
Venous Sinus ◽  
Stent Insertion ◽  
Benign Intracranial Hypertension ◽  
Content Type ◽  
Venous Sinuses ◽  
Pseudotumor Cerebri Syndrome ◽  
New Treatment ◽  
Fine Print

Object. Pseudotumor cerebri, or benign intracranial hypertension, is a condition of raised intracranial pressure in the absence of a mass lesion or cerebral edema. It is characterized by headache and visual deterioration that may culminate in blindness. Pseudotumor cerebri is caused by venous sinus obstruction in an unknown percentage of cases. The purpose of this study was to investigate the role of cerebral venous sinus disease in pseudotumor cerebri and the potential of endoluminal venous sinus stent placement as a new treatment. Methods. Nine consecutive patients in whom diagnoses of pseudotumor cerebri had been made underwent examination with direct retrograde cerebral venography (DRCV) and manometry to characterize the morphological features and venous pressures in their cerebral venous sinuses. The cerebrospinal fluid (CSF) pressure was measured simultaneously in two patients. If patients had an amenable lesion they were treated using an endoluminal venous sinus stent. Five patients demonstrated morphological obstruction of the venous transverse sinuses (TSs). All lesions were associated with a distinct pressure gradient and raised proximal venous sinus pressures. Four patients underwent stent insertion in the venous sinuses and reported that their headaches improved immediately after the procedure and remained so at 6 months. Vision was improved in three patients, whereas it remained poor in one despite normalized CSF pressures. Conclusions. Patients with pseudotumor cerebri should be evaluated with DRCV and manometry because venous TS obstruction is probably more common than is currently appreciated. In patients with a lesion of the venous sinuses, treatment with an endoluminal venous sinus stent is a viable alternative for amenable lesions.

Non-Syndromic Craniosynostosis Mimicking Primary Pseudotumor Cerebri Syndrome

2018 ◽  
Vol 59 (2) ◽  
pp. 264-265 ◽  
Author(s):  
Elissa K. Ortolani ◽  
Robert Safier ◽  
Ellen B. Mitchell ◽  
Catalina Cleves-Bayon
Keyword(s):  
Pseudotumor Cerebri ◽  
Syndromic Craniosynostosis ◽  
Pseudotumor Cerebri Syndrome

scholarly journals Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children

Neurology ◽  
2014 ◽  
Vol 83 (2) ◽  
pp. 198-200 ◽  
Author(s):  
M. Wall ◽  
J. J. Corbett ◽  
D. I. Friedman ◽  
G. Liu ◽  
K. Digre
Keyword(s):  
Diagnostic Criteria ◽  
Pseudotumor Cerebri ◽  
Pseudotumor Cerebri Syndrome ◽  
Adults And Children

scholarly journals Sepsis as a cause of intrahepatic cholestasis

2009 ◽  
Vol 137 (5-6) ◽  
pp. 278-281
Author(s):  
Jelena Rudic ◽  
Rada Jesic ◽  
Djordje Culafic ◽  
Radmila Sarenac-Kovac ◽  
Vladislava Bulat ◽  
...  
Keyword(s):  
Antibiotic Treatment ◽  
Intrahepatic Cholestasis ◽  
Liver Function Tests ◽  
Biliary Cirrhosis ◽  
Abdominal Ultrasonography ◽  
Laboratory Findings ◽  
Bile Formation ◽  
Normocytic Normochromic Anaemia ◽  
Inflammatory Syndrome ◽  
Possible Cause

Introduction. The causes of intrahepatic cholestasis include cholestatic viral hepatitis, primary biliary cirrhosis, benign recurrent cholestasis, primary sclerosing cholangitis and sepsis. During sepsis, proinflammatory cytokines and nitric oxide cause cholestasis by impairing hepatocellular and ductal bile formation. Case Outline. We report a 48-year-old woman who was admitted to hospital due to malaise, jaundice, fever and pain in the neck. Physical examination revealed jaundice, tachycardia (pulse rate was 120/min), hypotension 90/60 mm Hg. Laboratory findings showed normocytic normochromic anaemia, inflammatory syndrome and abnormal liver function tests indicating cholestasis and hepatocellular necrosis. Abdominal ultrasonography detected hepatosplenomegaly. Chest computed tomography showed bronchopneumonic infiltrates. Percutaneous liver biopsy was performed using a Menghini needle of 1.4 mm. Pathohystological analysis of the liver tissue confirmed reactive, intrahepatic cholestasis. Blood cultures isolated Staphylococcus aureus. After the diagnosis was established the treatment with broad-spectrum antibiotics was carried out, resulting in the improvement of general condition of the patient, regression of inflammatory syndrome, disappearance of cholestasis and regression of pulmonary infiltrates. Abdominal ultrasonography after antibiotic treatment did not show hepatosplenomegaly. Conclusion. Concerning patients with cholestasis of uncertain origin, we should always think of sepsis as a possible cause in order to start antibiotic treatment in time.

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