Development of Low Glycemic Index (GI) Foods by Incorporating Pulse Ingredients into Cereal-Based Products: Use of In Vitro Screening and In Vivo Methodologies

2017 ◽  
Vol 94 (1) ◽  
pp. 110-116 ◽  
Author(s):  
Natsuki Fujiwara ◽  
Clifford Hall ◽  
Alexandra L. Jenkins
Keyword(s):  
Glycemic Index ◽  
In Vitro Screening ◽  
Low Glycemic Index

scholarly journals The Glycemic Index Value of Hipa 7 and the Determination Method

2020 ◽  
Vol 16 (1) ◽  
pp. 19
Author(s):  
Dody Dwi Handoko ◽  
Siti Dewi Indrasari
Keyword(s):  
Blood Glucose ◽  
Glycemic Index ◽  
Rice Variety ◽  
Brown Rice ◽  
Physiological Effect ◽  
Milled Rice ◽  
Glucose Response ◽  
Low Glycemic Index

Carbohydrate content information of food does not enough to describe its physiological effect. Different carbohydrate sources give diverse blood glucose response. The concept of glycemic index (GI) was introduced to fill that gap. It divides food into several classifications according to their postprandial glycemic response. The original method was conducted by observing blood glucose after consuming sample then comparing the result with standard food. Later, miscellaneous in vitro digestion models were developed to mimic the in vivo condition. Rice is one of food types that have various GI which are related to the rice variety and postharvest processing method. There are some varieties that have low or medium GI, the others have higher. Parboiled and brown rice tend to have lower GI compared to their un-parboilled milled rice form.  Hipa 7 is hybrid new superior variety that that had been launched by ICRR in 2009 and its milled rice has low glycemic index 49.2. Low glycemic index rice potentially reduced the occurrence of obesity and diabetic mellitus disease.

scholarly journals Glycemic Index of Gluten-Free Bread and Their Main Ingredients: A Systematic Review and Meta-Analysis

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 506
Author(s):  
Bernardo Romão ◽  
Ana Luísa Falcomer ◽  
Gabriela Palos ◽  
Sandra Cavalcante ◽  
Raquel Braz Assunção Botelho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Glycemic Index ◽  
Resistant Starch ◽  
Web Of Science ◽  
Meta Analysis ◽  
Gluten Free ◽  
Inclusion Criteria ◽  
Glycemic Profile

This study aimed to perform a systematic review and meta-analysis of the glycemic index (GI) of gluten-free bread (GFB) and its main ingredients. The systematic review followed PRISMA guidelines, using seven electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, gray literature research with Google Scholar, and patents with Google Patent tool), from inception to November 2020. Eighteen studies met the inclusion criteria evaluating 132 GFB samples. Five articles tested GI in vivo, eleven in vitro; and two studies tested both methods. The analysis showed that 60.7% (95% CI: 40.2–78.1%) of the samples presented high glycemic indexes, evidencing a high glycemic profile for GFB. Only 18.2% (95% CI: 11.7–27.2%) of the bread samples presented in the studies were classified as a low GI. Meta-analysis presented moderate/low heterogenicity between studies (I2 = 61% and <1% for both high and low GIs) and reinforced the proportion of high GIs. Lower GIs were found in formulations based on Colocasia esculenta flour or enriched with fiber, yogurt and curd cheese, sourdough, psyllium, hydrocolloids, enzymes, fructans, and resistant starch, highlighting the efficacy of these ingredients to lower GFBs’ GI. GFB tends to present high GI, impacting the development of chronic diseases when consumed.

scholarly journals Formulation, High Throughput In Vitro Screening and In Vivo Functional Characterization of Nanoemulsion-Based Intranasal Vaccine Adjuvants

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126120 ◽  
Author(s):  
Pamela T. Wong ◽  
Pascale R. Leroueil ◽  
Douglas M. Smith ◽  
Susan Ciotti ◽  
Anna U. Bielinska ◽  
...  
Keyword(s):  
High Throughput ◽  
Functional Characterization ◽  
In Vitro Screening ◽  
Vaccine Adjuvants ◽  
Intranasal Vaccine

scholarly journals Quercetin Alleviates Intestinal Oxidative Damage Induced by H2O2 via Modulation of GSH: In Vitro Screening and In Vivo Evaluation in a Colitis Model of Mice

ACS Omega ◽  
2020 ◽  
Vol 5 (14) ◽  
pp. 8334-8346 ◽  
Author(s):  
Yuanyang Dong ◽  
Qihang Hou ◽  
Jiaqi Lei ◽  
Patricia G. Wolf ◽  
Hammed Ayansola ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
In Vitro Screening ◽  
In Vivo Evaluation ◽  
Colitis Model

scholarly journals Design, synthesis and in vivo/in vitro screening of novel chlorokojic acid derivatives

2012 ◽  
Vol 28 (3) ◽  
pp. 627-638 ◽  
Author(s):  
Gülşah Karakaya ◽  
Mutlu Dilsiz Aytemir ◽  
Berrin Özçelik ◽  
Ünsal Çalış
Keyword(s):  
In Vitro Screening ◽  
Design Synthesis

scholarly journals In Vitro Screening for Drug Repositioning

2014 ◽  
Vol 20 (2) ◽  
pp. 167-179 ◽  
Author(s):  
Graeme F. Wilkinson ◽  
Kevin Pritchard
Keyword(s):  
Scientific Literature ◽  
Drug Repositioning ◽  
Short Review ◽  
In Vitro Screening ◽  
Compound Libraries ◽  
Starting Point ◽  
Viable Method ◽  
Large Compound

Drug repositioning or repurposing has received much coverage in the scientific literature in recent years and has been responsible for the generation of both new intellectual property and investigational new drug submissions. The literature indicates a significant trend toward the use of computational- or informatics-based methods for generating initial repositioning hypotheses, followed by focused assessment of biological activity in phenotypic assays. Another viable method for drug repositioning is in vitro screening of known drugs or drug-like molecules, initially in disease-relevant phenotypic assays, to identify and validate candidates for repositioning. This approach can use large compound libraries or can focus on subsets of known drugs or drug-like molecules. In this short review, we focus on ways to generate and validate repositioning candidates in disease-related in vitro and phenotypic assays, and we discuss specific examples of this approach as applied to a variety of disease areas. We propose that in vitro screens offer several advantages over biochemical or in vivo methods as a starting point for drug repositioning.

Activation of inflammatory cells and cytokines by peptide epitopes in vitro: a simple in-vitro screening assay for prioritizing them for in-vivo studies

2013 ◽  
Vol 62 (5) ◽  
pp. 471-481 ◽  
Author(s):  
Lakshmi A. Mundkur ◽  
Meenakshi Varma ◽  
Hemapriya Shivanandan ◽  
Dhanush Krishna ◽  
Kiran Kumar ◽  
...  
Keyword(s):  
Inflammatory Cells ◽  
In Vivo Studies ◽  
In Vitro Screening ◽  
Screening Assay ◽  
Peptide Epitopes

scholarly journals Screening of Allium Tester Lines in Vitro with Pyrenochaeta terrestris Filtrates

HortScience ◽  
1992 ◽  
Vol 27 (2) ◽  
pp. 166-168 ◽  
Author(s):  
Andrew C. Ludwig ◽  
John F. Hubstenberger ◽  
Gregory C. Phillips ◽  
G. Morris Southward
Keyword(s):  
Allium Cepa ◽  
Fungal Pathogen ◽  
Callus Cultures ◽  
In Vitro Screening ◽  
Root Pathogen ◽  
Field Nursery ◽  
Pyrenochaeta Terrestris ◽  
Root Resistance

Callus cultures were established from intraspecific lines of Allium cepa L., interspecific F1 progeny of A. cepa crossed to A. fistulosum L. and to A. galanthum L., advanced generations of A. fistulosum x A. cepa backcrossed to A. cepa, and lines of A. fistulosum and A. galanthum. These genotypes had been identified as susceptible, resistant, or partially resistant tester lines based on prior seedling and field nursery screenings using the pink-root pathogen Pyrenochaeta terrestris (Hansen) Gorenz, Walker and Larson. Tester line calli were challenged in vitro with culture filtrates of the fungal pathogen and were assessed by visible damage ratings expressed as the percentage of pigmentation in response to the filtrate. The degrees of callus sensitivity to the filtrate observed in vitro corresponded well with the in vivo tester line classifications. These results eliminated the possible confounding influence of using various species of Allium for in vitro screening. Our results indicated the suitability of the in vitro screening approach for the possible identification of useful segregants or somaclonal variants possessing pink-root resistance. However, in vivo pathogenicity may involve mechanisms in addition to sensitivity to the putative toxins present in the filtrate.

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