scholarly journals Identification of Quantitative Trait Loci Controlling Symptom Development During Viral Infection in Arabidopsis thaliana

2008 ◽  
Vol 21 (2) ◽  
pp. 198-207 ◽  
Author(s):  
Ophélie Sicard ◽  
Olivier Loudet ◽  
Joost J. B. Keurentjes ◽  
Thierry Candresse ◽  
Olivier Le Gall ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Large Degree ◽  
Chromosome 1 ◽  
Phenotypic Trait ◽  
Plum Pox Virus ◽  
Symptom Development ◽  
Trait Loci ◽  
Viral Accumulation

In compatible interactions between plants and viruses that result in systemic infection, symptom development is a major phenotypic trait. However, host determinants governing this trait are mostly unknown, and the mechanisms underlying it are still poorly understood. In a previous study on the Arabidopsis thaliana–Plum pox virus (PPV) pathosystem, we showed a large degree of variation in symptom development among susceptible accessions. In particular, Cvi-1 (Cape Verde islands) accumulates viral particules but remains symptomless, Col-0 (Columbia) sometimes shows weak symptoms compared with Ler (Landsberg erecta), which always shows severe symptoms. Genetic analyses of Col × Ler and Cvi × Ler F2 and recombinant inbred line (RIL) populations suggested that symptom development as well as viral accumulation traits are polygenic and quantitative. Three of the symptom quantitative trait loci (QTL) identified could be confirmed in near-isogenic lines, including PSI1 (PPV symptom induction 1), which was identified on the distal part of chromosome 1 in both RIL populations. With respect to viral accumulation, several factors have been detected and, interestingly, in the Col × Ler population, two out of three viral accumulation QTL colocalized with loci controlling symptom development, although correlation analysis showed weak linearity between symptom severity and virus accumulation. In addition, in the Cvi × Ler RIL population, a digenic recessive determinant controlling PPV infection was identified.

scholarly journals Identification of Quantitative Trait Loci Influencing Traits Related to Energy Balance in Selection and Inbred Lines of Mice

Genetics ◽  
1999 ◽  
Vol 152 (2) ◽  
pp. 699-711 ◽  
Author(s):  
D E Moody ◽  
D Pomp ◽  
M K Nielsen ◽  
L D Van Vleck
Keyword(s):  
Quantitative Trait Loci ◽  
Energy Balance ◽  
Heat Loss ◽  
Quantitative Trait ◽  
Subcutaneous Fat ◽  
High Heat ◽  
Chromosome 1 ◽  
Direct Calorimetry ◽  
Resource Population ◽  
Trait Loci

Abstract Energy balance is a complex trait with relevance to the study of human obesity and maintenance energy requirements of livestock. The objective of this study was to identify, using unique mouse models, quantitative trait loci (QTL) influencing traits that contribute to variation in energy balance. Two F2 resource populations were created from lines of mice differing in heat loss measured by direct calorimetry as an indicator of energy expenditure. The HB F2 resource population originated from a cross between a noninbred line selected for high heat loss and an inbred line with low heat loss. Evidence for significant QTL influencing heat loss was found on chromosomes 1, 2, 3, and 7. Significant QTL influencing body weight and percentage gonadal fat, brown fat, liver, and heart were also identified. The LH F2 resource population originated from noninbred lines of mice that had undergone divergent selection for heat loss. Chromosomes 1 and 3 were evaluated. The QTL for heat loss identified on chromosome 1 in the HB population was confirmed in the LH population, although the effect was smaller. The presence of a QTL influencing 6-wk weight was also confirmed. Suggestive evidence for additional QTL influencing heat loss, percentage subcutaneous fat, and percentage heart was found for chromosome 1.

scholarly journals Genetic analysis identifies quantitative trait loci controlling rosette mineral concentrations in Arabidopsis thaliana under drought

2009 ◽  
Vol 184 (1) ◽  
pp. 180-192 ◽  
Author(s):  
Artak Ghandilyan ◽  
Luis Barboza ◽  
Sébastien Tisné ◽  
Christine Granier ◽  
Matthieu Reymond ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Quantitative Trait Loci ◽  
Genetic Analysis ◽  
Quantitative Trait ◽  
Trait Loci ◽  
Mineral Concentrations

scholarly journals Variation in Seed Dormancy Quantitative Trait Loci in Arabidopsis thaliana Originating from One Site

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20886 ◽  
Author(s):  
Rebecca A. Silady ◽  
Sigi Effgen ◽  
Maarten Koornneef ◽  
Matthieu Reymond
Keyword(s):  
Arabidopsis Thaliana ◽  
Quantitative Trait Loci ◽  
Seed Dormancy ◽  
Quantitative Trait ◽  
Trait Loci

Detection of quantitative trait loci for locomotion and osteochondrosis-related traits in Large White ✕ Meishan pigs

2003 ◽  
Vol 76 (2) ◽  
pp. 155-165 ◽  
Author(s):  
G.J. Lee ◽  
A.L. Archibald ◽  
G.B. Garth ◽  
A.S. Law ◽  
D. Nicholson ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Chromosome 1 ◽  
Chromosome 15 ◽  
Large White ◽  
Chromosome 13 ◽  
Genome Wide ◽  
A Genome ◽  
Trait Loci ◽  
Gait Score

AbstractData from the F2 generation of a Large White (LW) ✕ Meishan (MS) crossbred population were analysed to detect quantitative trait loci (QTL) for leg and gait scores, osteochondrosis and physis scores. Legs, feet and gait score were assessed in 308 F2 animals at 85 ( + 5) kg and osteochondrosis and physis scores were recorded for the right foreleg after slaughter. A genome scan was performed using 111 genetic markers chosen to span the genome that were genotyped on the F2 animals and their F1 parents and purebred grandparents. A QTL on chromosome 1 affecting gait score was significant at the genome-wide significance level. Additional QTL significant at the chromosome-wide 5% threshold level (approx. equivalent to the genome-wide suggestive level) were detected on chromosome 1 for front feet and back legs scores, on chromosome 13 for front legs and front feet scores, on chromosome 14 for front legs, front feet and back legs scores and on chromosome 15 for back feet score. None of the QTL for osteochondrosis score exceeded the chromosome-wide suggestive level, but one chromosome-wide QTL for physis score was found on chromosome 7. On chromosome 1, gait and front feet scores mapped to the middle of the chromosome and showed additive effects in favour of the LW alleles and no dominance effects. The QTL for back legs score mapped to the distal end of the chromosome and showed a dominant effect and no additive effect. On chromosomes 14 and 15, the LW allele was again superior to the MS allele. On chromosome 13, there were both additive and dominance effects in favour of the MS allele. The MS alleles on chromosome 13 may have potential for introgression into a commercial LW population. The other putative QTLs identified may have value in marker-assisted selection in LW or MS-synthetic populations.

Quantitative trait loci for insulin-like growth factor I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice

2003 ◽  
Vol 15 (1) ◽  
pp. 44-51 ◽  
Author(s):  
James M. Harper ◽  
Andrzej T. Galecki ◽  
David T. Burke ◽  
Stephen L. Pinkosky ◽  
Richard A. Miller
Keyword(s):  
Quantitative Trait Loci ◽  
Growth Factor ◽  
Quantitative Trait ◽  
Chromosome 1 ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Genotype Information ◽  
Igf I ◽  
Trait Loci ◽  
Growth Factor I

Genotype information was collected at 87 loci in a group of 1,108 UM-HET3 mice bred as the progeny of [BALB/cJ × C57BL/6J]F1 mothers and [C3H/HeJ × DBA/2J]F1 fathers, for which thyroxine (T4), insulin-like growth factor I (IGF-I), and leptin levels had been measured at 4 and 15 mo of age. The data provided significant evidence for quantitative trait loci (QTL) modulating IGF-I levels on chromosomes 1, 3, 8, 10, and 17; for loci affecting T4 on chromosomes 4, 15, and 17; and for leptin on chromosome 3. Fecal levels of corticosterone at 17 mo of age were influenced by a QTL on chromosome 1. Nine other gene/hormone associations reached a nominal P < 0.01, providing suggestive but not statistical evidence for additional QTL. QTL with an influence on a given hormone were in nearly all cases additive, with little or no evidence for epistasis. Of the 12 strongest QTL, 5 had effects that were age dependent, having more effect in 15-mo-old than in 4-mo-old mice in all but one case; the other QTL had effects that were apparently age-independent. These results show that the genetic controls over late-life hormone levels are complex and dependent on effects of genes that act both early and late in the life course.

In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1

2018 ◽  
Vol 29 (9-10) ◽  
pp. 632-655 ◽  
Author(s):  
Darryl L. Hadsell ◽  
Louise A. Hadsell ◽  
Monique Rijnkels ◽  
Yareli Carcamo-Bahena ◽  
Jerry Wei ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
In Silico ◽  
Chromosome 1 ◽  
In Silico Mapping ◽  
Trait Loci

scholarly journals Mapping of the Egusi Seed Trait Locus (eg) and Quantitative Trait Loci Associated with Seed Oil Percentage in Watermelon

2012 ◽  
Vol 137 (5) ◽  
pp. 311-315 ◽  
Author(s):  
Jason Prothro ◽  
Katherine Sandlin ◽  
Rattandeep Gill ◽  
Eleni Bachlava ◽  
Victoria White ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Seed Oil ◽  
Citrullus Lanatus ◽  
Recessive Gene ◽  
Phenotypic Trait ◽  
Single Recessive Gene ◽  
Seed Trait ◽  
Oil Percentage ◽  
Trait Loci

The egusi watermelon (Citrullus lanatus) is popular in West Africa for its oil and protein-rich seed, which is consumed in soups and stews. The egusi phenotypic trait is controlled by a single recessive gene (eg) and is characterized by large seed size and fleshy, thick pericarp. An F2 mapping population was derived from Strain II (PI 279461) of the Japanese cultivar Yamato-cream with normal seed type and low seed oil percentage (SOP = 25.2%) and an egusi type from Nigeria [Egusi (PI 560023)] with high SOP (40.6%). Genetic analysis confirmed that the egusi seed trait is controlled by a single recessive gene (eg) and the location of the gene was mapped to 57.8 cM on linkage group (LG) 2, between markers NW0248325 and NW0250248. Four main quantitative trait loci (M-QTL) were identified for SOP in the population with the eg locus contributing 84% of the explained phenotypic variation (R2). A significant epistatic interaction (E-QTL) was identified between, the eg locus and an M-QTL on LG 9B. The present study reports the location of the eg locus responsible for the egusi seed trait in watermelon on LG 2 as well as M-QTL and E-QTL associated with SOP.

scholarly journals Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1.

1996 ◽  
Vol 97 (3) ◽  
pp. 777-788 ◽  
Author(s):  
L Gu ◽  
H Dene ◽  
A Y Deng ◽  
B Hoebee ◽  
M T Bihoreau ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Quantitative Trait Loci ◽  
Genetic Mapping ◽  
Quantitative Trait ◽  
Chromosome 1 ◽  
Trait Loci
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