scholarly journals Maize Leaf Epiphytic Bacteria Diversity Patterns Are Genetically Correlated with Resistance to Fungal Pathogen Infection

2010 ◽  
Vol 23 (4) ◽  
pp. 473-484 ◽  
Author(s):  
Peter Balint-Kurti ◽  
Susan J. Simmons ◽  
James E. Blum ◽  
Carlos L. Ballaré ◽  
Ann E. Stapleton
Keyword(s):  
Bacterial Diversity ◽  
Glutamate Decarboxylase ◽  
Radiation Effects ◽  
Gamma Aminobutyric Acid ◽  
Plant Leaves ◽  
Chromosomal Locus ◽  
Specific Effects ◽  
Allele Specific ◽  
Solar Uv ◽  
Ri Lines

Plant leaves host a specific set of microbial epiphytes. Plant genetic and solar UV-B radiation effects on the diversity of the phyllosphere were examined by measuring epiphytic bacterial ribosomal DNA diversity in a maize recombinant inbred (RI) mapping population. Several chromosomal quantitative trait loci (QTL) with significant effects on bacterial diversity were identified, some of which had effects only in the presence of UV-B radiation and others that had effects both with and without UV-B. Candidate genes with allele-specific effects were mapped to the bacterial diversity chromosomal regions. A glutamate decarboxylase candidate gene was located at a UV-B–specific chromosomal locus, and in a comparison between two RI lines with contrasting bacterial diversity phenotypes, high bacterial diversity was associated with high levels of glutamate decarboxylase enzyme activity, a component of the gamma-aminobutyric acid (GABA) pathway. The bacterial diversity loci exhibited a significant overlap with loci connected with Southern leaf blight (SLB) susceptibility in the field. A SLB-resistant inbred genotype had less beta bacterial diversity, and antibiotic treatment of inbreds increased this diversity. These results suggest that the GABA pathway is genetically associated with phyllosphere bacterial diversity. Furthermore, the colocalization of QTL between low bacterial diversity and fungal blight–resistance and the increase in beta diversity in antibiotic-treated leaves suggest that occupation of leaf habitats by a particular set of suppressive bacteria may restrict phyllosphere bacterial variability and increase resistance to fungal infection.

scholarly journals Prediction of smoking by multiplex bisulfite PCR with long amplicons considering allele-specific effects on DNA methylation

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Nikolay Kondratyev ◽  
Arkady Golov ◽  
Margarita Alfimova ◽  
Tatiana Lezheiko ◽  
Vera Golimbet
Keyword(s):  
Dna Methylation ◽  
Specific Effects ◽  
Allele Specific

scholarly journals Identification of a non‐coding SNP associated with risk for non‐syndromic orofacial clefting with allele‐specific effects on IRF6 expression in vitro

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Priyanka Kumari ◽  
Ryan Friedman ◽  
Lira Pi ◽  
Annika Helverson ◽  
Sarah Curtis ◽  
...  
Keyword(s):  
Orofacial Clefting ◽  
Specific Effects ◽  
Allele Specific ◽  
Coding Snp

Differential Activity of Ras1 during Patterning of the Drosophila Dorsoventral Axis

Genetics ◽  
1996 ◽  
Vol 144 (4) ◽  
pp. 1545-1557 ◽  
Author(s):  
Jon D Schnorr ◽  
Celeste A Berg
Keyword(s):  
Tyrosine Kinases ◽  
P Element ◽  
Embryonic Patterning ◽  
Loss Of Function ◽  
Wing Vein ◽  
Border Cell ◽  
Specific Effects ◽  
Vein Formation ◽  
Allele Specific ◽  
Development Analysis

In Drosophila, the Ras1 gene is required downstream of receptor tyrosine kinases for correct eye development, embryonic patterning, wing vein formation, and border cell migration. Here we characterize a P-element allele of Ras1, Ras15703, that affects viability, eye morphogenesis, and early and late stages of oogenesis. Flies transheterozgyous for Ras15703 and existing EMS-induced Ras1 alleles are viable and exhibit a range of eye and eggshell defects. Differences in the severity of these phenotypes in different tissues suggest that there are allele-specific effects of Ras1 in development. Analysis of rescue constructs demonstrates that these differential phenotypes are due to loss of function in Ras1 alone and not due to effects on neighboring genes. Females mutant at the Ras1 locus lay eggs with reduced or missing dorsal eggshell structures. We observe dominant interactions between Ras1 mutants and other dorsoventral pathway mutants, including and Egfrtop and gurken. Ras1 is also epistatic to K10. Unlike Egfrtop and gurken mutants, however, Ras1 females are moderately fertile, laying eggs with ventralized eggshells that can hatch normal larvae. These results suggest that Ras1 may have a different requirement in the patterning of the eggshell axis than in the patterning of the embryonic axis during oogenesis.

Metabolite specific effects of solar UV-A and UV-B on alder and birch leaf phenolics

2008 ◽  
Vol 14 (6) ◽  
pp. 1294-1304 ◽  
Author(s):  
TITTA KOTILAINEN ◽  
RIITTA TEGELBERG ◽  
RIITTA JULKUNEN-TIITTO ◽  
ANDERS LINDFORS ◽  
PEDRO J. APHALO
Keyword(s):  
Specific Effects ◽  
Solar Uv ◽  
Leaf Phenolics

Allele-Specific Effects of ecSOD in Bacterial Infection

2017 ◽  
Vol 112 ◽  
pp. 205
Author(s):  
Sujung Jun ◽  
Byung-Jin Kim ◽  
Timothy J Break ◽  
Rance E Berg ◽  
Harlan P Jones ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Specific Effects ◽  
Allele Specific

scholarly journals Deficiency of the Stroke Relevant HDAC9 Gene Attenuates Atherosclerosis in Accord With Allele-Specific Effects at 7p21.1

Stroke ◽  
2015 ◽  
Vol 46 (1) ◽  
pp. 197-202 ◽  
Author(s):  
Sepiede Azghandi ◽  
Caroline Prell ◽  
Sander W. van der Laan ◽  
Manuela Schneider ◽  
Rainer Malik ◽  
...  
Keyword(s):  
Specific Effects ◽  
Allele Specific

scholarly journals Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats

2013 ◽  
Vol 8 (1) ◽  
pp. 82 ◽  
Author(s):  
Christiane S Hampe ◽  
Laura Petrosini ◽  
Paola De Bartolo ◽  
Paola Caporali ◽  
Debora Cutuli ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Cognitive Functions ◽  
Glutamate Decarboxylase ◽  
Specific Effects

scholarly journals Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice

2021 ◽  
Vol 22 (24) ◽  
pp. 13305
Author(s):  
Maren K. Schroeder ◽  
Bin Liu ◽  
Robert G. Hinshaw ◽  
Mi-Ae Park ◽  
Shuyan Wang ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Radiation Effects ◽  
Motor Coordination ◽  
Space Radiation ◽  
High Energy ◽  
High Energy Particle ◽  
Wild Type ◽  
Particle Radiation ◽  
Specific Effects

Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle radiation cause physiological and behavioral impairments in rodents and may pose risks to human spaceflight. There is evidence that 56Fe irradiation, a significant component of space radiation, may be more harmful to males than to females and worsen Alzheimer’s disease pathology in genetically vulnerable models. Yet, research on the long-term, sex- and genotype-specific effects of 56Fe irradiation is lacking. Here, we irradiated 4-month-old male and female, wild-type and Alzheimer’s-like APP/PS1 mice with 0, 0.10, or 0.50 Gy of 56Fe ions (1GeV/u). Mice underwent microPET scans before and 7.5 months after irradiation, a battery of behavioral tests at 11 months of age and were sacrificed for pathological and biochemical analyses at 12 months of age. 56Fe irradiation worsened amyloid-beta (Aβ) pathology, gliosis, neuroinflammation and spatial memory, but improved motor coordination, in male transgenic mice and worsened fear memory in wild-type males. Although sham-irradiated female APP/PS1 mice had more cerebral Aβ and gliosis than sham-irradiated male transgenics, female mice of both genotypes were relatively spared from radiation effects 8 months later. These results provide evidence for sex-specific, long-term CNS effects of space radiation.

Sign in / Sign up

Export Citation Format

Share Document