scholarly journals Role of Histamine in Implantation: Inhibition of H istid me Decarboxylase Induces Delayed Implantation in the Rabbit

1981 ◽  
Vol 24 (4) ◽  
pp. 867-869 ◽  
Author(s):  
S. K. Dey
Keyword(s):  
Delayed Implantation

THE ROLE OF ELECTROLYTES OF THE ENDOMETRIUM AND UTERINE FLUID DURING DELAYED IMPLANTATION IN RATS

1973 ◽  
Vol 59 (3) ◽  
pp. 461-464 ◽  
Author(s):  
B. S. SETTY ◽  
MAN MOHAN SINGH ◽  
S. R. CHOWDHURY ◽  
AMIYA B. KAR
Keyword(s):  
Electrolyte Concentration ◽  
Delayed Implantation ◽  
Uterine Fluid ◽  
Sodium And Potassium

SUMMARY Sodium and potassium levels were determined in the rat endometrium and uterine washings during normal and 'delayed' implantation. Both endometrium and uterine washings of normal rats differed from those of 'delayed' animals in their electrolyte concentrations. A dose of oestradiol dipropionate (1 μg/rat) capable of inducing implantation in 'delayed' rats (ovariectomized and maintained on progesterone) did not evoke any significant changes in electrolyte concentration of either the endometrium or uterine washings. These findings are discussed in the light of a hypothesis regarding delayed implantation in rats.

THE ROLE OF THE PITUITARY GLAND IN IMPLANTATION IN THE MOUSE: DELAY OF IMPLANTATION BY HYPOPHYSECTOMY AND NEURODEPRESSIVE DRUGS

1969 ◽  
Vol 43 (2) ◽  
pp. 225-235 ◽  
Author(s):  
B. M. BINDON
Keyword(s):  
Pituitary Gland ◽  
Early Pregnancy ◽  
Single Injection ◽  
Hormone Replacement ◽  
Oestrous Cycle ◽  
The Other ◽  
Optimum Conditions ◽  
Delayed Implantation ◽  
Long Acting

SUMMARY The optimum conditions for delay of implantation by hypophysectomy and neurodepressive agents are described. Hypophysectomy on day 1 without hormone replacement was followed by retarded development and subsequent degeneration of zygotes. Viability of blastocysts was maintained under these conditions by a single injection of a long-acting progestagen on day 1. Hypophysectomy at intervals beginning late on day 3 indicated that implantation is initiated by pituitary activity in the several hours around midnight of this day. In animals induced to ovulate and copulate by exogenous gonadotrophin injections, the corresponding time of pituitary activity was delayed by approximately 8 hr. This delay could not be explained solely on the basis of altered times of ovulation. It is evident that the events of early pregnancy do not follow the normal physiological pattern under these conditions, and caution should be exercised in utilizing such animals. Of five neurodepressive agents examined, only trifluoperazine effectively delayed implantation. The effect of this substance injected at various times on day 3 of pregnancy suggests that implantation in the mouse is initiated by neurally regulated pituitary activity between 16.00 and 24.00 hr. on this day. Comparison with the mechanism of ovulation indicates that ovulation and implantation are regulated by separate hypothalamic-pituitary events, one peculiar to the oestrous cycle, the other to early pregnancy.

scholarly journals The effect of microstructure of the surface, the design and dimension of dental implants on their stability and the process of osteointegration during immediate and delayed implantation. PartII

2021 ◽  
Vol 108 (4) ◽  
pp. 34-38
Author(s):  
P. Grishin ◽  
◽  
E. Mamaeva ◽  
E. Kalinnikova ◽  
A. Kozlov ◽  
...  
Keyword(s):  
Primary Stability ◽  
Implant Surface ◽  
Surface Design ◽  
Resonance Analysis ◽  
Delayed Implantation ◽  
Size Type ◽  
The Stability ◽  
The Moment ◽  
Immediate Implantation

Abstract. This article presents the results of a clinical study of the stability and process of osteointegration implants of 11 known implant dental systems. The effect of the microstructure of 3 types of implant surface (HSTTM, SLA and RBM) and their design features (shape, size, type of carving) on the indicators of their stability and osteointegration process during immediate and delayed implantation with immediate functional load is shown and analyzed. The stability of the implants and the dynamics of the quality of osteointegration were determined by the devices «Osstell Mentor» and «Periotest» in the process of treatment, starting from the moment of implant installation in different eras (2 weeks, 1 month, 2 months and 3 months). 414 patients between the ages of 20 and 70 were monitored. Of these, there are 249 and 165 male women. The average age of the operated patients was: for men – 54 years for women – 49 years. All patients were divided into two groups of the first – 109 patients who after extraction were directly implanted into the hole of the remote tooth with the subsequent immediate load, the second group – 305 patients who were delayed implantation with immediate load. A total of 1,302 implants were installed. The study revealed a link between the type of surface of the implant, primary stability and the time of its osteointegration during certain periods of clinical observation. The results of the study demonstrated the important role of combining microstructure of the surface, design and dimension features, the type of insertion of implants on their primary stability and the process of osteointegration in the conduct of both immediate and delayed implantation. Key words: frequency resonance analysis, damping, stability, osteointegration, fixation, implants, periotestometry, immediate implantation.

scholarly journals Utilizing a rat delayed implantation model to teach integrative endocrinology and reproductive biology

2018 ◽  
Vol 42 (1) ◽  
pp. 56-63
Author(s):  
Rodney D. Geisert ◽  
Michael F. Smith ◽  
Amanda L. Schmelzle ◽  
Jonathan A. Green
Keyword(s):  
Embryo Implantation ◽  
Female Rats ◽  
Laboratory Exercise ◽  
Ici 182,780 ◽  
Delayed Implantation ◽  
Simple Protocol ◽  
Student Discussion ◽  
Discussion Question ◽  
Implantation Model

In this teaching laboratory, the students are directed in an exercise that involves designing and performing an experiment to determine estrogen’s role in regulating delayed implantation (diapause) in female rats. To encourage active participation by the students, a discussion question is provided before the laboratory exercise in which each student is asked to search the literature and provide written answers to questions and to formulate an experiment to test the role of ovarian estrogen in inducing implantation in female rats. One week before the laboratory exercise, students discuss their answers to the questions with the instructor to develop an experiment to test their hypothesis that estrogen is involved with inducing implantation in the rat. A rat delayed implantation model was established that utilizes an estrogen receptor antagonist (ICI 182,780), which inhibits the action of ovarian estrogens. Groups of mated females are treated with either carrier (control) or ICI 182,780 (ICI) every other day, starting on day 2 postcoitus (pc) until day 8 pc. One-half of the females receiving ICI are injected with estradiol-17β on day 8 pc to induce implantation 4 days after the controls. If the ICI-treated females are not administered estradiol, embryo implantation occurs spontaneously ~4 days after the last ICI injection on day 8. This is a very simple protocol that is very effective and provides an excellent experiment for student discussion on hormone action and the use of agonists and antagonists.

scholarly journals The effect of microstructure of the surface, the design and dimension of dental implants on their stability and the process of osteointegration during immediate and delayed implantation

2021 ◽  
Vol 107 (3) ◽  
pp. 58-63
Author(s):  
P. Grishin ◽  
◽  
E. Mamaeva ◽  
E. Kalinnikova ◽  
A. Kozlov ◽  
...  
Keyword(s):  
Primary Stability ◽  
Implant Surface ◽  
Surface Design ◽  
Resonance Analysis ◽  
Delayed Implantation ◽  
Size Type ◽  
The Stability ◽  
The Moment ◽  
Immediate Implantation

Abstract. This article presents the results of a clinical study of the stability and process of osteointegration implants of 11 known implant dental systems. The effect of the microstructure of 3 types of implant surface (HSTTM, SLA and RBM) and their design features (shape, size, type of carving) on the indicators of their stability and osteointegration process during immediate and delayed implantation with immediate functional load is shown and analyzed. The stability of the implants and the dynamics of the quality of osteointegration were determined by the devices «Osstell Mentor» and «Periotest» in the process of treatment, starting from the moment of implant installation in different eras (2 weeks, 1 month, 2 months and 3 months). 414 patients between the ages of 20 and 70 were monitored. Of these, there are 249 and 165 male women. The average age of the operated patients was: for men – 54 years for women – 49 years. All patients were divided into two groups of the first – 109 patients who after extraction were directly implanted into the hole of the remote tooth with the subsequent immediate load, the second group – 305 patients who were delayed implantation with immediate load. A total of 1,302 implants were installed. The study revealed a link between the type of surface of the implant, primary stability and the time of its osteointegration during certain periods of clinical observation. The results of the study demonstrated the important role of combining microstructure of the surface, design and dimension features, the type of insertion of implants on their primary stability and the process of osteointegration in the conduct of both immediate and delayed implantation. Key words: frequency resonance analysis, damping, stability, osteointegration, fixation, implants, periotestometry, immediate implantation.

scholarly journals Pre-implantation mouse embryo movement under hormonally altered conditions

2021 ◽  
Author(s):  
Hannah Lufkin ◽  
Diana Flores ◽  
Zachary Raider ◽  
Manoj Madhavan ◽  
Madeline Dawson ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Ovarian Hormones ◽  
Delayed Implantation ◽  
Naturally Occurring ◽  
Key Players ◽  
Alternate Model ◽  
Implantation Success

Precise regulation of embryo movement is crucial to successful implantation, but the role of ovarian hormones in this process is not understood. We ascertain the effects of altered hormonal environment on embryo movement using two delayed implantation models: Natural lactational Diapause (ND), a naturally occurring alternate model of pregnancy, and Artificially induced Diapause (AD), a laboratory version of ND. Our previous work suggests that embryos in a natural pregnancy (NP) first display unidirectional clustered embryo movement, followed by bidirectional scattering and spacing movement. In contrast, in the ND model, embryos are present as clusters near the oviductal-uterine junction for ~24-hours longer than NP, followed by locations consistent with a unidirectional scattering and spacing movement. Intriguingly, the AD model closely resembles embryo location in NP and not ND. Further, unlike the popular paradigm of reduced estrogen (E2) levels in diapause E2 levels are comparable across NP, ND, and AD, while progesterone (P4) levels are reduced in ND and highly increased in AD when compared to NP. Exogenous administration of E2 or P4 modifies the unidirectional clustered embryo movement, while E2 treatment causes a reduction in P4 and affects the bidirectional phase of embryo movement. Taken together, our data suggest embryo movement can be modulated by both P4 and E2. Understanding natural hormonal adaptation in diapause provides an opportunity to determine key players regulating embryo movement and implantation success. This knowledge can be leveraged to understand pregnancy survival and implantation success in hormonally altered conditions in the clinic.

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor

Role of the allergist in diagnosis and management of patients with uveitis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 167-172 ◽  
Author(s):  
T. E. Van Metre
Keyword(s):  
Diagnosis And Management

The power of norms to sway fused group members

2018 ◽  
Vol 41 ◽  
Author(s):  
Winnifred R. Louis ◽  
Craig McGarty ◽  
Emma F. Thomas ◽  
Catherine E. Amiot ◽  
Fathali M. Moghaddam
Keyword(s):  
Evolutionary Anthropology ◽  
Normative Systems ◽  
Violent Extremism ◽  
Identity Fusion ◽  
Group Members

AbstractWhitehouse adapts insights from evolutionary anthropology to interpret extreme self-sacrifice through the concept of identity fusion. The model neglects the role of normative systems in shaping behaviors, especially in relation to violent extremism. In peaceful groups, increasing fusion will actually decrease extremism. Groups collectively appraise threats and opportunities, actively debate action options, and rarely choose violence toward self or others.

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