Waist circumference modifies the relationship between ethnicity/race and type 2 diabetes among adults in the NHANES

Women with type 2 diabetes (T2DM) have an increased susceptibility of developing cardio-renal disease compared to men, the reasons and the mechanisms of this vulnerability are unclear. Since oxidative stress plays a key role in the development of cardio-renal disease, we investigated the relationship between sex, plasma antioxidants status (glutathione peroxidase (GPx-3 activity), vitamin E and selenium), and adiposity in patients with T2DM at high risk of cardio-renal disease. Women compared to men had higher GPx-3 activity (p = 0.02), bio-impedance (p ≤ 0.0001), and an increase in waist circumference in relation to recommended cut off-points (p = 0.0001). Waist circumference and BMI were negatively correlated with GPx-3 activity (p ≤ 0.05 and p ≤ 0.01, respectively) and selenium concentration (p ≤ 0.01 and p ≤ 0.02, respectively). In multiple regression analysis, waist circumference and sex were independent predictors of GPx-3 activity (p ≤ 0.05 and p ≤ 0.05, respectively). The data suggest that increased central fat deposits are associated with reduced plasma antioxidants which could contribute to the future risk of cardio-renal disease. The increased GPx-3 activity in women could represent a preserved response to the disproportionate increase in visceral fat. Future studies should be aimed at evaluating if the modulation of GPx-3 activity reduces cardio-renal risk in men and women with T2DM.

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The Relationship between Plasma alpha-Tocopherol Concentration and Vitamin E Intake in Patients with Type 2 Diabetes Mellitus

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000046 ◽

2011 ◽

Vol 81 (1) ◽

pp. 12-20 ◽

Cited By ~ 3

Author(s):

Vanessa K. Illison ◽

Patricia H.C. Rondó ◽

Andréia M. de Oliveira ◽

Francisco H. D’Abronzo ◽

Katia F. Campos

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Vitamin E ◽

Waist Circumference ◽

Total Cholesterol ◽

Alpha Tocopherol ◽

Tocopherol Concentration ◽

The Relationship

Type 2 diabetes mellitus (DM2) predisposes to an increased production of free radicals and a probable reduction in plasma antioxidants, including vitamin E. This cross-sectional study investigated the relationship between plasma alpha-Tocopherol concentration and vitamin E intake in 58 Brazilians with DM2. Plasma alpha-Tocopherol was determined by high-performance liquid chromatography. The intake of vitamin E-rich foods was assessed by a food frequency questionnaire. Total cholesterol and fractions were measured by colorimetric enzymatic methods. Data on demographic and socioeconomic factors, life habits, and anthropometry were obtained by a questionnaire and physical examination. The association between plasma alpha-Tocopherol and vitamin E intake was assessed by multiple linear regression analysis. The following variables were included in the regression model: alpha-Tocopherol, vitamin E intake, total cholesterol and fractions, body mass index, waist circumference, gender, age, education, occupation, income, smoking, alcohol intake, and blood pressure. There was no association between alpha-Tocopherol and vitamin E intake, but there were significant associations between alpha-Tocopherol and total cholesterol (p < 0.001) and waist circumference (p = 0.003). There were 36.2 % diabetics with low alpha-Tocopherol concentrations (< 12 µmol/L) and 32.7 % with a low alpha-Tocopherol/total cholesterol ratio (< 2.2). Further large, epidemiological, longitudinal studies, including measurements of gamma-tocopherol in blood, should be conducted to confirm our results.

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The relationship between waist circumference on obesity and prevalence of type 2 diabetes mellitus in male patients in the Regional Public Hospital of Tabanan Regency

The Proceedings of the 1st Seminar The Emerging of Novel Corona Virus, nCov 2020, 11-12 February 2020, Bali, Indonesia ◽

10.4108/eai.11-2-2020.2302030 ◽

2020 ◽

Author(s):

L G Evayanti ◽

B G A D Hendra ◽

S H Indonesiani

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Waist Circumference ◽

Public Hospital ◽

Male Patients ◽

The Relationship

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The Relationship between Hypertriglyceridemic Waist Phenotype and Early Diabetic Nephropathy in Type 2 Diabetes

Cardiorenal Medicine ◽

10.1159/000477828 ◽

2017 ◽

Vol 7 (4) ◽

pp. 295-300 ◽

Cited By ~ 8

Author(s):

Chun-Ming Ma ◽

Rui Wang ◽

Xiao-Li Liu ◽

Na Lu ◽

Qiang Lu ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Nephropathy ◽

Waist Circumference ◽

Glycosylated Hemoglobin ◽

Serum Triglyceride ◽

Hypertriglyceridemic Waist ◽

The Relationship ◽

Early Diabetic Nephropathy ◽

Diabetes Patients

Background/Aims: The aim of this study was to explore the relationship between hypertriglyceridemic waist (HW) phenotype and early diabetic nephropathy in type 2 diabetes. Methods: A cross-sectional study was conducted on 538 type 2 diabetes patients in Qinhuangdao. The HW phenotype was defined as serum triglyceride concentrations ≥1.7 mmol/L and waist circumference ≥90 cm (males) and ≥85 cm (females). Results: The prevalence of the HW phenotype was 34.9%. The prevalence of early diabetic nephropathy was 10.6% in type 2 diabetes patients with normal waist circumference and triglycerides and 24.5% in type 2 diabetes patients with HW phenotype. After adjustment for sex, age, body mass index, hypertension, history of diabetes, and glycosylated hemoglobin A1c, the prevalence of early diabetic nephropathy among type 2 diabetes patients with the HW phenotype was 2.81 (95% confidence interval 1.36-5.80, p = 0.005) times higher than that among type 2 diabetes patients with normal waist circumference and triglycerides. Conclusion: There was a significant correlation between HW phenotype and early diabetic nephropathy in type 2 diabetes.

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