scholarly journals Guided by COMPASS on a Journey Through Chromatin Modifications, Regulation of Gene Expression and the Pathogenesis of Leukemia

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Ali Shilatifard
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Chromatin Modifications

scholarly journals Metabolic regulation of chromatin modifications and gene expression

2018 ◽  
Vol 217 (7) ◽  
pp. 2247-2259 ◽  
Author(s):  
Juan Manuel Schvartzman ◽  
Craig B. Thompson ◽  
Lydia W.S. Finley
Keyword(s):  
Gene Expression ◽  
Cell Fate ◽  
Metabolic Regulation ◽  
Regulation Of Gene Expression ◽  
Enzymatic Reaction ◽  
Chromatin Modifications ◽  
Dynamic Regulation ◽  
Local Conditions ◽  
Control Of Gene Expression ◽  
Cell Fate Decisions

Dynamic regulation of gene expression in response to changing local conditions is critical for the survival of all organisms. In metazoans, coherent regulation of gene expression programs underlies the development of functionally distinct cell lineages. The cooperation between transcription factors and the chromatin landscape enables precise control of gene expression in response to cell-intrinsic and cell-extrinsic signals. Many of the chemical modifications that decorate DNA and histones are adducts derived from intermediates of cellular metabolic pathways. In addition, several of the enzymes that can remove these marks use metabolites as part of their enzymatic reaction. These observations have led to the hypothesis that fluctuations in metabolite levels influence the deposition and removal of chromatin modifications. In this review, we consider the emerging evidence that cellular metabolic activity contributes to gene expression and cell fate decisions through metabolite-dependent effects on chromatin organization.

scholarly journals Chromatin modifications: implications in the regulation of gene expression inToxoplasma gondii

2010 ◽  
Vol 12 (4) ◽  
pp. 413-423 ◽  
Author(s):  
Alexandre Bougdour ◽  
Laurence Braun ◽  
Dominique Cannella ◽  
Mohamed-Ali Hakimi
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Chromatin Modifications

scholarly journals An Overview of the Epigenetic Modifications of Gene Expression in Tumorigenesis

2019 ◽  
Author(s):  
Leili Sadeghi Amiri ◽  
Ali Barzegar ◽  
Alireza Rafiei ◽  
Omolbanin Amjadi
Keyword(s):  
Gene Expression ◽  
Cell Transformation ◽  
Regulation Of Gene Expression ◽  
Malignant Cell ◽  
Chromatin Modifications ◽  
Chromatin Compaction ◽  
Cellular Processes ◽  
The Past ◽  
Development And Differentiation ◽  
Malignant Cell Transformation

The five leading causes of cancer-related deaths are lung (1,760,000 deaths), colorectal (862,000 deaths), stomach (783,000 deaths), liver (782,000 deaths), and breast (627,000 deaths) cancers. Epigenetic changes can alter chromatin compaction, leading to the regulation of gene expression without changing the primary DNA sequence. Epigenetic mechanisms are normally involved in cellular processes such as genomic stability, chromosome X inactivation, and embryonic development and differentiation. Similar to other types of chromatin modifications, DNA methylation has been verified to affect the expression of various genes. Any impairment in these mechanisms alters the regulation of gene expression and can contribute to malignant cell transformation. Over the past few years, extensive innovations within the field of epigenetics have encouraged its application as a major strategy for the treatment of important diseases such as cancer.

Linking transcription, RNA polymerase II elongation and alternative splicing

2020 ◽  
Vol 477 (16) ◽  
pp. 3091-3104 ◽  
Author(s):  
Luciana E. Giono ◽  
Alberto R. Kornblihtt
Keyword(s):  
Gene Expression ◽  
Alternative Splicing ◽  
Rna Polymerase Ii ◽  
Environmental Changes ◽  
Transcription Elongation ◽  
Single Gene ◽  
Regulation Of Gene Expression ◽  
Regulation Of Transcription ◽  
Stepping Stones ◽  
Eukaryotic Transcription

Gene expression is an intricately regulated process that is at the basis of cell differentiation, the maintenance of cell identity and the cellular responses to environmental changes. Alternative splicing, the process by which multiple functionally distinct transcripts are generated from a single gene, is one of the main mechanisms that contribute to expand the coding capacity of genomes and help explain the level of complexity achieved by higher organisms. Eukaryotic transcription is subject to multiple layers of regulation both intrinsic — such as promoter structure — and dynamic, allowing the cell to respond to internal and external signals. Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcription elongation, making it a regulatory knob on a par with the regulation of gene expression levels. This review aims to recapitulate some of the history and stepping-stones that led to the paradigms held today about transcription and splicing regulation, with major focus on transcription elongation and its effect on alternative splicing.

Regulation of gene expression by TR and CREB: a binding and competition contract

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
JM Weitzel ◽  
A Wulf ◽  
M Rajkovic ◽  
HJ Seitz
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression
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