Antioxidant Activities of Green Synthesized Zinc Oxide Nanoparticles and its Curative Influence in Carbon tetrachloride‐Induced Hepatorenal Damage in Adult Rats

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Chiagoziem A. Otuechere ◽  
Adriel Ekozin ◽  
Adewale Adewuyi
Keyword(s):  
Zinc Oxide ◽  
Carbon Tetrachloride ◽  
Zinc Oxide Nanoparticles ◽  
Antioxidant Activities ◽  
Oxide Nanoparticles ◽  
Adult Rats

Sunflower Assisted Bio-derived ZnO-NPs as an Efficient Nanocatalyst for Synthesis of Novel Quinazolines with Highly Antioxidant Activities

2021 ◽  
Author(s):  
Balaji GL ◽  
S. Mahesh ◽  
Boya Palajonnala Narasaiah ◽  
Sadegh Rostamnia ◽  
Harihara Padhy ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Antioxidant Activities ◽  
Present Report ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Green Method ◽  
Vis Spectroscopy

Abstract The present report an environmental benign route for the fabrication of Zinc Oxide nanoparticles (ZnO-NPs) using sunflower leaf aqueous extract at room temperature. This was an green method is a rapid biogenic and offers few advantages over the chemical and physical procedures, as it is an easy and fast, eco-friendly and does not involve any costly chemicals as well as hazardous chemicals, harmful solvent. The synthesized ZnO-NPs were characterized using different technique such as UV-Visible spectroscopy. The formation of ZnO-NPs was confirmed by Surface Plasmon Resonance (SRP) at 344 nm using UV-Vis spectroscopy. The leaf extract act as a source of phyto-chemicals and are the primarily responsible for the reduction and then formation of stable Zinc Oxide nanoparticles by the characteristic functional groups of extract and synthesized ZnO-NPs were identified by FTIR spectroscopy. Crystalline nature of ZnO-NPs was confirmed by powder –XRD. Size and morphology were measured by HR-TEM analysis. Stability of the nanoparticles is represented by DLS and TGA analysis. The synthesized ZnO-NPs has been found good and efficient catalyst for the synthesis of novel 1,2-dihydroquinazoline derivatives under green method via one pot reaction of 2-amino benzophenone, 1,3-diphenyl-1 H -pyrazole carbaldehydes and ammonium acetate. The synthesized compounds (4a-o) were characterized by 1 HNMR, 13 CNMR and HRMS spectra and further screened for radical scavenging activity. Among all the compounds showed good percentage of inhibition against standard ascorbic acid. The synthesized ZnO nanoparticles showed good antioxidant activity and also act as a good promising material for catalytic agent.

Acute exposure to zinc oxide nanoparticles does not affect the cognitive capacity and neurotransmitters levels in adult rats

2014 ◽  
Vol 8 (sup1) ◽  
pp. 208-215 ◽  
Author(s):  
Salem Amara ◽  
Imen Ben-Slama ◽  
Imen Mrad ◽  
Naima Rihane ◽  
Mustapha Jeljeli ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Cognitive Capacity ◽  
Acute Exposure ◽  
Oxide Nanoparticles ◽  
Adult Rats

scholarly journals Green synthesized Zinc Oxide Nanoparticles Elicited a Prominent Suppression of Oxidative and Inflammatory Distortions in Rats Exposed to Carbon Tetrachloride

2021 ◽  
Vol 12 (4) ◽  
pp. 5444-5457
Keyword(s):  
Electron Microscopy ◽  
Zinc Oxide ◽  
Carbon Tetrachloride ◽  
Zinc Oxide Nanoparticles ◽  
Glutathione Transferase ◽  
Oxide Nanoparticles ◽  
Gamma Glutamyl Transferase ◽  
Leaf Extracts ◽  
Anti Inflammatory ◽  
Glutamyl Transferase

This study centered on Zinc oxide nanoparticles capped with Pterocarpus mildbraedii leaf extracts (PmZnONPs) as a potent antioxidant and anti-inflammatory agent against carbon tetrachloride (CCl4) ‐ induced hepatorenal toxicity in rats. PmZnONPs were characterized by Fourier transform infrared spectroscopy (FTIR), Brunauer–Emmett–Teller (BET), scanning electron microscopy (SEM), X-ray diffraction pattern (XRD), and transmission electron microscopy (TEM) techniques. The FTIR results revealed the presence of various functional groups in PmZnONPs, while the BET showed a surface area of 1.55 mg-2. In vitro, PmZnONPS showed comparable 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) radicals scavenging activities as Vitamin C. After that, PmZnONPs (1 and 3 mg/kg) were administered (p.o.) into six groups of rats, using CCl4 as the toxicant. The obtained results demonstrated that PmZnONPS significantly prevented CCl4‐induced elevations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma‐glutamyl transferase (GGT), alkaline phosphatase (ALP), bilirubin (BIL), creatinine, and urea. Moreover, PmZnONPs restored the levels of plasma uric acid, hepatorenal antioxidant enzymes, including superoxide dismutase, glutathione peroxidase, glutathione transferase, and glutathione that were significantly decreased by CCl4 treatment. Immunohistochemical studies showed that PmZnONPs significantly suppressed the high immunoreactivity of nuclear factor kappa B (NF‐κB), cyclooxygenase‐2 (COX-2), and interleukin‐6 (IL-6) arising from CCl4 intoxication. Thus our data hint that PmZnONPs suppressed CCl4‐induced toxicity in the liver and kidney of rats via its combined antioxidant and anti‐inflammatory properties.

scholarly journals Investigation of the Zinc Oxide Nanoparticles Effect on Thyroid and Testosterone Hormones in Male Rats

2020 ◽  
Vol 4 (1) ◽  
pp. 26-31
Author(s):  
Noori M. Luaibi ◽  
Noor A. Zayed
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Thyroid Stimulating Hormone ◽  
Male Rats ◽  
Oxide Nanoparticles ◽  
Sprague Dawley ◽  
Zno Nps ◽  
Adult Rats ◽  
Male Adult ◽  
Intraperitoneal Dose

Exposure to zinc oxide nanoparticles (ZnO NPs) has been increasing steadily, causing more attention being paid to their potential toxicity, including cytotoxicity and genotoxicity. Hence, this study aimed to investigate the effect of ZnO NPs on thyroid hormone triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) as well as testosterone hormone in male adult rats. A total of 54 Sprague-Dawley albino adult male rats were divided into nine groups each of six rats, daily treated intraperitoneal with ZnO NPs two different doses (30 and 60) mg/kg in three different periods of time (7, 14, and 28) days, as following: Control groups (Groups 1, 2, and 3): Respectively received intraperitoneal injection with distilled water for 7, 14, and 28 days, experimental groups (Groups 4, 5, and 6): They were rats, respectively, received intraperitoneal dose (60 mg/kg) of ZnO NPs for (7, 14, and 28) days, and group (7, 8, and 9) experimental groups were rats, respectively, received intraperitoneal dose (30 mg/kg) of ZnO NPs for (7, 14, and 28) days. Data showed high significant decrease (P < 0.01) in level of T3, T4, TSH, and level of testosterone also decrease at high and low dose for 7, 14, and 28 days.

scholarly journals Leonotis Nepetifolia Mediated Eco-Friendly Synthesis of Zno Nps: Photocatalytic, Antioxidant Activities and Their Applications to Nano-Composite Electrode Material for Supercapacitor

2021 ◽  
Author(s):  
Gajendran Pavithra ◽  
Santhakumar kannappan
Keyword(s):  
Electron Microscopy ◽  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Zinc Oxide Nanoparticles ◽  
Antioxidant Activities ◽  
Electrochemical Analysis ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Pure Zinc ◽  
X Ray

Abstract The present paper describes the green synthesis of Zinc oxide nanoparticles (ZnO NPs) from the flowers of L. nepetifolia. The synthesis of ZnO nanoparticles and examined by using Ultraviolet-visible spectroscopy, Fourier Transform-Infrared spectroscopy, X-ray Diffraction analysis, Dynamic Light Scattering analysis, Raman spectroscopy, Scanning Electron Microscopy and Energy Dispersive X-ray spectroscopy, Transmission Electron Microscopy, and Thermogravimetric Analysis. The photocatalytic studies were followed using methylene blue (MB) dye by ZnO nanoparticles by using sunlight as a source. The degradation of MB dye is found to be 90 %. Then the synthesized ZnO nanoparticles help to evaluate the antioxidant activities. The antioxidant activities of ZnO nanoparticles were exhibiting through scavenging of Nitric oxide, Hydrogen peroxide, and DPPH free radicals. Furthermore, the electrochemical analysis of reduced Graphene Oxide-Zinc oxide (rGO-ZnO) nanocomposite shows that the prepared rGO-ZnO nanocomposite has a high specific capacitance of about 667 F g-1 in comparison with the pure Zinc oxide nanoparticles (200 F g-1) and has good cycling stability of around 1000 cycles. The synthesis of multifunctional ZnO nanoparticles by using natural plant products like seeds, leaves, flowers, etc may help to explore as environment-friendly which is opposite to chemical synthesis.

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