Corticosterone at physiological dose accelerates the healing of experimental gastric erosions in rats

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Ludmila Filaretova ◽  
Olga Komkova ◽  
Olga Morozova
Keyword(s):  
Gastric Erosions ◽  
Physiological Dose

Evaluation of radiological findings of complete gastric erosions

1987 ◽  
Vol 23 (3) ◽  
pp. 432
Author(s):  
H S Jung ◽  
S S Choi ◽  
Y S Lim ◽  
B C Kim ◽  
Y S Chung ◽  
...  
Keyword(s):  
Radiological Findings ◽  
Gastric Erosions

FEMALE ENDOCRINE CONTROL MECHANISMS DURING THE NEONATAL PERIOD

1972 ◽  
Vol 70 (2) ◽  
pp. 396-408 ◽  
Author(s):  
K.-D. Schulz ◽  
H. Haarmann ◽  
A. Harland
Keyword(s):  
Protein Synthesis ◽  
Reproductive System ◽  
Rna Synthesis ◽  
Neonatal Period ◽  
High Dose ◽  
Female Reproductive System ◽  
Endocrine Control ◽  
Hypothalamic Region ◽  
Rna And Protein Synthesis ◽  
Physiological Dose

ABSTRACT The present investigation deals with the oestrogen-sensitivity of the female reproductive system during the neonatal period. Newborn female guinea pigs were used as test animals. At different times after a single subcutaneous injection of a physiological dose of 0.1 μg or an unphysiologically high dose of 10 μg 17β-oestradiol/100 g body weight, the RNA- and protein-synthesis was examined in the hypothalamic region, pituitary, cerebral cortex, liver, adrenal gland, ovary and uterus. With a physiological dose an increase in organ weight, protein content, RNA-and protein-synthesis was found only in the uterus. These alterations turned out to be dose-dependent. In addition to the findings in the uterus an inhibition of the aminoacid incorporation rate occurred in the liver following the injection of the high oestradiol dose. As early as 1 hour after the administration of 0.1 μg 17β-oestradiol an almost 100% increase in uterine protein synthesis was detectable. This result demonstrates a high oestrogen-sensitivity of this organ during the neonatal period. All the other organs of the female reproductive system such as the hypothalamus, pituitary and ovary did not show any oestrogen response. Therefore the functional immaturity of the uterus during post partem life is not the result of a deficient hormone sensitivity but is correlated with the absence of a sufficient hormonal stimulus at this time. The investigation on the effects of actinomycin resulted in different reactions in the uterus and liver. In contrast to the liver a paradoxical actinomycin effect was found in the uterus after treatment with actinomycin alone. This effect is characterized by a small inhibition of RNA-synthesis and a 50% increase in protein synthesis. The treatment of the newborn test animals with actinomycin and 17β-oestradiol together abolished the oestrogen-induced stimulation of the uterine RNA-and protein-synthesis. Consequently, the effect of oestrogens during the neonatal period is also connected with the formation of new proteins via an increased DNA-directed RNA-synthesis.

Gastroprotective action of glucocorticoids during the formation and the healing of indomethacin-induced gastric erosions in rats

2001 ◽  
Vol 95 (1-6) ◽  
pp. 201-208 ◽  
Author(s):  
Ludmila Filaretova ◽  
Tatiana Podvigina ◽  
Tatiana Bagaeva ◽  
Gabor Makara
Keyword(s):  
Gastric Erosions ◽  
Gastroprotective Action

Estimation of dose-response curves and identification of peaks in hormone pulsations: classic marriages of statistics to science

2005 ◽  
Vol 289 (3) ◽  
pp. E363-E365 ◽  
Author(s):  
Douglas Curran-Everett
Keyword(s):  
Dose Response ◽  
Hormone Secretion ◽  
Simultaneous Analysis ◽  
Response Curves ◽  
Radioligand Assay ◽  
Historical Significance ◽  
Dose Response Curves ◽  
Physiological Dose ◽  
Classic Papers

This essay examines the historical significance of two APS classic papers that are freely available online: De Léan A, Munson PJ, and Rodbard D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol Endocrinol Metab Gastrointest Physiol 235: E97–E102, 1978 ( http://ajplegacy.physiology.org/cgi/reprint/235/2/E97 ). Merriam GR and Wachter KW.Algorithms for the study of episodic hormone secretion. Am J Physiol Endocrinol Metab 243: E310–E318, 1982 ( http://ajplegacy.physiology.org/cgi/reprint/243/4/E310 ).

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 ◽  
Vol 235 (2) ◽  
pp. E97 ◽  
Author(s):  
A DeLean ◽  
P J Munson ◽  
D Rodbard
Keyword(s):  
Statistical Analysis ◽  
Dose Response ◽  
Curve Shape ◽  
Response Curves ◽  
Pharmacological Studies ◽  
Rigorous Statistical Analysis ◽  
Efficient Data ◽  
Dose Response Curves ◽  
Physiological Dose ◽  
Efficient Data Analysis

Physiological and pharmacological studies of hormones, drugs, and neurotransmitters often generate families of sigmoidal dose-response curves. Optimally efficient data analysis should involve simultaneous description of all curves, rather than fitting each one individually. We have developed a general computerized method to describe the dose-response curves in terms of basal and maximal responses, ED50, and curve shape or steepness. This facile method permits rigorous statistical analysis, provides a basis for pooling of information from separate experiments, and allows one to test which characteristics are shared by various curves.

Regulation of renal Na+-K+-ATPase in the rat: role of increased potassium transport

1986 ◽  
Vol 251 (2) ◽  
pp. F199-F207
Author(s):  
S. K. Mujais ◽  
M. A. Chekal ◽  
J. P. Hayslett ◽  
A. I. Katz
Keyword(s):  
Enzyme Activity ◽  
Atpase Activity ◽  
Potassium Transport ◽  
High Potassium ◽  
Dietary Potassium ◽  
Collecting Tubule ◽  
Physiological Dose ◽  
Potassium Loading ◽  
Cortical Collecting Tubule

The purpose of this study was to characterize the alterations in collecting tubule Na+-K+-ATPase activity produced by sustained increments in dietary potassium in the rat and to evaluate the role of aldosterone in their generation. In adrenal-intact animals, feeding a high-potassium diet (10-fold that of control) or administration of a high physiological dose of aldosterone (5 micrograms X 100 g-1 X day-1), which simulates the delivery rate of this hormone during potassium loading (both for 7 days), caused marked increments in Na+-K+-ATPase activity in the cortical collecting tubule (CCT) but had no effect on the enzyme in the inner stripe of the medullary collecting tubule (MCT). A significant increase in enzyme activity was also observed after smaller dietary potassium increments (2.5 and 5 times the control) and after 4 (but not 2) days of dietary potassium load. In adrenalectomized rats provided with physiological replacement doses of corticosterone and aldosterone (0.8 micrograms X 100 g-1 X day-1), Na+-K+-ATPase activity in both CCT and MCT was similar to that of adrenal-intact controls but remained unchanged after 7 days on the potassium-enriched (10-fold) diet. In contrast, adrenalectomized animals receiving the high physiological dose of aldosterone displayed an increase in Na+-K+-ATPase activity of CCT comparable with that of adrenal-intact animals, whereas the enzyme activity in the MCT was unaffected. In conclusion, 1) following chronic potassium loading Na+-K+-ATPase activity increases significantly in the CCT with no change in its activity in the inner stripe of the MCT.(ABSTRACT TRUNCATED AT 250 WORDS)

Renal effects of atrial natriuretic peptide in a marine elasmobranch

1990 ◽  
Vol 258 (5) ◽  
pp. R1201-R1206 ◽  
Author(s):  
S. Benyajati ◽  
S. D. Yokota
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Aortic Pressure ◽  
Renal Effects ◽  
Physiological Dose ◽  
Excretion Rates ◽  
Solute Excretion ◽  
Mammalian Peptide ◽  
Mean Aortic Pressure ◽  
Atrial Natriuretic

The effects of atrial natriuretic peptide on the renal function of the spiny dogfish (Squalus acanthias) in seawater were evaluated. A synthetic mammalian peptide, atriopeptin II (2 micrograms/kg), was injected intravascularly into unanesthetized, unrestrained fish prepared for renal clearance studies. The aortic pressure, glomerular filtration rate (GFR), urine flow rate (V), and urinary excretion of sodium, potassium, and total osmolytes were continuously monitored. Atriopeptin II significantly decreased mean aortic pressure (-12%), GFR (-40%), V (-66%), and the absolute excretion rates of sodium (-47%), potassium (-43%), and total osmolytes (-44%). However, the renal effects of atriopeptin II were temporally dissociated from the vasodepressor effect. Mean aortic pressure decreased quickly and returned to control values approximately 2 h after injection, whereas GFR did not decrease significantly until the third hour after injection. The decreases in renal water and solute excretion in response to atriopeptin could be accounted for by the decrease in GFR, since there were no significant changes in fractional water or solute excretion. Similar decreases in GFR were observed during constant infusions of a lower physiological dose of the peptide (80 pg.kg-1.min-1). The observed antidiuretic and antinatriuretic effect of synthetic atriopeptin in the dogfish contrasts with its putative role as a hormone mediating hypervolemic regulation.

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