scholarly journals Low‐dose lithium supplementation augments mitochondrial biogenesis in murine skeletal muscle after high fat feeding

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Jisook Ryoo ◽  
Mia Geromella ◽  
Chantal Ryan ◽  
Rachel Fenech ◽  
Jessica Braun ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Biogenesis ◽  
Low Dose ◽  
High Fat ◽  
Murine Skeletal Muscle ◽  
Fat Feeding

scholarly journals Long‐Term High‐Fat Feeding Reduces the Numbers of Satellite Cells and Myonuclei in the Adult Murine Skeletal Muscle Fibers

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Mohammed Z. Allouh ◽  
Bright Starling-Emerald ◽  
Mohammed A. Al Jailani
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cells ◽  
Muscle Fibers ◽  
High Fat ◽  
Skeletal Muscle Fibers ◽  
Murine Skeletal Muscle ◽  
Fat Feeding

Skeletal Muscle Mitochondrial, Obesity, and High-Fat Feeding

2019 ◽  
pp. 117-123
Author(s):  
Christelle Guillet
Keyword(s):  
Skeletal Muscle ◽  
High Fat ◽  
Fat Feeding

scholarly journals Selective overexpression of Toll-like receptor-4 in skeletal muscle impairs metabolic adaptation to high-fat feeding

2015 ◽  
Vol 309 (3) ◽  
pp. R304-R313 ◽  
Author(s):  
Ryan P. McMillan ◽  
Yaru Wu ◽  
Kevin Voelker ◽  
Gabrielle Fundaro ◽  
John Kavanaugh ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
High Fat Diet ◽  
Whole Body ◽  
Metabolic Adaptation ◽  
Acid Oxidation ◽  
Chow Diet ◽  
Toll Like Receptor ◽  
High Fat ◽  
Toll Like Receptor 4 ◽  
Fat Feeding

Toll-like receptor-4 (TLR-4) is elevated in skeletal muscle of obese humans, and data from our laboratory have shown that activation of TLR-4 in skeletal muscle via LPS results in decreased fatty acid oxidation (FAO). The purpose of this study was to determine whether overexpression of TLR-4 in skeletal muscle alters mitochondrial function and whole body metabolism in the context of a chow and high-fat diet. C57BL/6J mice (males, 6–8 mo of age) with skeletal muscle-specific overexpression of the TLR-4 (mTLR-4) gene were created and used for this study. Isolated mitochondria and whole muscle homogenates from rodent skeletal muscle (gastrocnemius and quadriceps) were investigated. TLR-4 overexpression resulted in a significant reduction in FAO in muscle homogenates; however, mitochondrial respiration and reactive oxygen species (ROS) production did not appear to be affected on a standard chow diet. To determine the role of TLR-4 overexpression in skeletal muscle in response to high-fat feeding, mTLR-4 mice and WT control mice were fed low- and high-fat diets for 16 wk. The high-fat diet significantly decreased FAO in mTLR-4 mice, which was observed in concert with elevated body weight and fat, greater glucose intolerance, and increase in production of ROS and cellular oxidative damage compared with WT littermates. These findings suggest that TLR-4 plays an important role in the metabolic response in skeletal muscle to high-fat feeding.

Caloric Restriction Followed by High Fat Feeding Predisposes to Oxidative Stress in Skeletal Muscle Mitochondria

2013 ◽  
Vol 45 (12) ◽  
pp. 874-879 ◽  
Author(s):  
R. Crescenzo ◽  
F. Bianco ◽  
P. Coppola ◽  
A. Mazzoli ◽  
G. Liverini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Caloric Restriction ◽  
High Fat ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria ◽  
Fat Feeding

High-fat feeding induces angiogenesis in skeletal muscle and activates angiogenic pathways in capillaries

Angiogenesis ◽  
2012 ◽  
Vol 16 (2) ◽  
pp. 297-307 ◽  
Author(s):  
Mika Silvennoinen ◽  
Rita Rinnankoski-Tuikka ◽  
Mikael Vuento ◽  
Juha J. Hulmi ◽  
Sira Torvinen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
High Fat ◽  
Fat Feeding

Skeletal muscle inflammation is not responsible for the rapid impairment in adiponectin response with high-fat feeding in rats

2010 ◽  
Vol 299 (2) ◽  
pp. R500-R508 ◽  
Author(s):  
Kerry L. Mullen ◽  
Justine M. Tishinsky ◽  
Lindsay E. Robinson ◽  
David J. Dyck
Keyword(s):  
Skeletal Muscle ◽  
Soleus Muscle ◽  
Inflammatory Diseases ◽  
Saturated Fat ◽  
Cytokine Signaling ◽  
Low Grade ◽  
High Fat ◽  
Muscle Inflammation ◽  
Inflammatory Proteins ◽  
Fat Feeding

Adiponectin (Ad) is an insulin-sensitizing adipokine known to stimulate fatty acid (FA) oxidation in skeletal muscle. Skeletal muscle can become resistant to Ad very rapidly, after only 3 days of high saturated fat feeding in rats. Whether the same occurs following a high polyunsaturated fat diet is unknown. Obesity, insulin resistance, and hyperlipidemia are recognized as low-grade inflammatory diseases; therefore, we hypothesized that high-fat feeding induces inflammation, which interferes with Ad action at skeletal muscle. To this end, rats were placed into one of three dietary groups, control (CON, 10% kcal from fat), high saturated (SAT), or high polyunsaturated (PUFA) fat (60% kcal from fat) for 3 days to determine whether Ad resistance develops. Half of the animals from each group were further supplemented with aspirin, a common anti-inflammatory drug. Ad stimulated FA metabolism, Ad signaling intermediates [AdipoR1, APPL1, LKB1, AMPK, and acetyl-CoA carboxylase (ACC)], and inflammatory proteins [Toll-like receptor (TLR4), IKKα/β, IκBα, NF-κB, suppressor of cytokine signaling-3 (SOCS3), and JNK] were measured in soleus muscle. Three days of SAT feeding induced Ad resistance in soleus muscle, assessed as an inability of Ad to phosphorylate ACC and increase FA oxidation. In PUFA-fed animals, Ad-stimulated FA oxidation and ACC phosphorylation to the same degree as CON animals (FA oxidation: +35%, +41%; pACC +29%, +19%; CON, PUFA, P < 0.05). However, neither SAT nor PUFA feeding for 3 days induced skeletal muscle inflammation. Surprisingly, aspirin prevented Ad-stimulated increases in FA oxidation. In conclusion, FA type is critical in the development of Ad resistance, but this does not appear to be mediated by inflammation.

Subsarcolemmal and intermyofibrillar mitochondrial responses to short-term high-fat feeding in rat skeletal muscle

Nutrition ◽  
2014 ◽  
Vol 30 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Raffaella Crescenzo ◽  
Francesca Bianco ◽  
Paola Coppola ◽  
Arianna Mazzoli ◽  
Giovanna Liverini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
High Fat ◽  
Rat Skeletal Muscle ◽  
Short Term ◽  
Fat Feeding

Preventive effect of curcumin on inflammation, oxidative stress and insulin resistance in high-fat fed obese rats

2016 ◽  
Vol 13 (2) ◽  
Author(s):  
Nachimuthu Maithilikarpagaselvi ◽  
Magadi Gopalakrishna Sridhar ◽  
Rathinam Palamalai Swaminathan ◽  
Ramalingam Sripradha
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Body Weight ◽  
Density Lipoprotein ◽  
High Fat ◽  
Oxidative Stress Parameters ◽  
Tnf Α ◽  
Male Wistar Rats ◽  
Fat Feeding

Abstract: The present study investigated the beneficial effects of curcumin on inflammation, oxidative stress and insulin resistance in high-fat fed male Wistar rats.: Five-month-old male Wistar rats (n=20) were divided into two groups (10 rats in each group). Among the two groups, one group received 30 % high-fat diet (HFD) and another group received 30 % HFD with curcumin (200 mg/kg body weight). Food intake, body weight and biochemical parameters were measured at the beginning and at the end of the study. After 10 weeks, oxidative stress parameters in skeletal muscle and hepatic triacylglycerol (TAG) content were estimated. Histological examinations of the liver samples were performed at the end of the experiment.: High-fat feeding caused increase in body weight, liver and adipose tissue mass. Rats fed with HFD showed increased levels of fasting plasma glucose, insulin, Homeostasis Model Assessment for Insulin resistance (HOMA-IR), total cholesterol (TC), TAG, very low density lipoprotein cholesterol (VLDL-c) and decreased high-density lipoprotein cholesterol (HDL-c). There was also increase in the plasma inflammatory markers [tumor necrosis factor-α (TNF-α), C-reactive protein (CRP)] and skeletal muscle oxidative stress parameters [malondialdehyde (MDA), total oxidant status (TOS)] in these rats. In addition, high-fat feeding increased liver TAG content and caused fat accumulation in the liver. Treatment with curcumin significantly reduced body weight, relative organ weights (liver, adipose tissue), glucose, insulin and HOMA-IR. Curcumin supplementation decreased plasma levels of TC, TAG, VLDL-c, TNF-α and increased HDL-c. Administration of curcumin also reduced MDA, TOS in skeletal muscle, hepatic TAG content and liver fat deposition.: Curcumin supplementation improved HFD-induced dyslipidemia, oxidative stress, inflammation and insulin resistance.

scholarly journals Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis

2014 ◽  
Vol 46 (9) ◽  
pp. 738-748 ◽  
Author(s):  
X. Li ◽  
Z. Xu ◽  
Z. Jiang ◽  
L. Sun ◽  
J. Ji ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Biogenesis ◽  
High Fat Diet ◽  
Hypoglycemic Effect ◽  
Diabetic Mice ◽  
High Fat

scholarly journals High-fat feeding does not induce an autophagic or apoptotic phenotype in female rat skeletal muscle

2014 ◽  
Vol 240 (5) ◽  
pp. 657-668 ◽  
Author(s):  
Troy L Campbell ◽  
Andrew S Mitchell ◽  
Elliott M McMillan ◽  
Darin Bloemberg ◽  
Dmytro Pavlov ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Female Rat ◽  
High Fat ◽  
Rat Skeletal Muscle ◽  
Fat Feeding
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