scholarly journals Role of Internal Ca2+ Stores in KCa Channel Feedback Control of Human Uterine Contractions

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Bri Kestler ◽  
Chung‐Sik Choi ◽  
Mark Taylor
Keyword(s):  
Feedback Control ◽  
Uterine Contractions ◽  
Channel Feedback

Role of Uterine Contractions and Intrapartum Reoxygenation Ratio

2017 ◽  
pp. 62-66
Author(s):  
Sadia Muhammad ◽  
Edwin Chandraharan
Keyword(s):  
Uterine Contractions

scholarly journals The Key Role of Warm and Cold Ischemia in Uterus Transplantation: A Review

2019 ◽  
Vol 8 (6) ◽  
pp. 760 ◽  
Author(s):  
Antoine Tardieu ◽  
Ludivine Dion ◽  
Vincent Lavoué ◽  
Pauline Chazelas ◽  
Pierre Marquet ◽  
...  
Keyword(s):  
Deceased Donor ◽  
Cold Ischemia ◽  
Uterus Transplantation ◽  
Uterine Contractions ◽  
Live Donors ◽  
Promising Treatment ◽  
Deceased Donors ◽  
Ischemia Tolerance ◽  
Large Animals

Introduction: Uterus transplantation (UTx) is a promising treatment for uterine infertility that has resulted in several births since 2014. Ischemia is a key step in organ transplantation because it may lead to changes jeopardizing graft viability. Method: We performed a systematic review of animal and human studies relating to uterine ischemia. Results: We retained 64 studies published since 2000. There were 35 studies in animals, 24 in humans, and five literature reviews. Modest preliminary results in large animals and humans are limited but encouraging. In small animals, pregnancies have been reported to occur after 24 h of cold ischemia (CI). In ewes, uterine contractions have been detected after 24 h of CI. Furthermore, it has been shown in animals that uterine tolerance to CI and to warm ischemia (WI) can be increased by pharmacological products. In women, mean CI time in studies of births from uteri obtained from live donors was between 2 h 47 min and 6 h 20 min from a deceased donor; with only one birth in this case. Muscle contractions have also been demonstrated in myometrial samples from women, after six or more hours of CI. Conclusion: The uterus seems to be able to tolerate a prolonged period of CI, of at least six hours. Studies of the ischemia tolerance of the uterus and ways to improve it are essential for the development of UTx, particularly for procedures using grafts from deceased donors.

scholarly journals Gastric branch vagotomy and gastric emptying during and after intragastric infusion of glucose

1997 ◽  
Vol 273 (5) ◽  
pp. R1786-R1792 ◽  
Author(s):  
Joel M. Kaplan ◽  
William H. Siemers ◽  
Ulrika Smedh ◽  
Gary J. Schwartz ◽  
Harvey J. Grill
Keyword(s):  
Gastric Emptying ◽  
Feedback Control ◽  
Inhibitory Control ◽  
Inhibitory Mechanisms ◽  
Two Phases ◽  
And Control ◽  
Vagal Efferents ◽  
Receptive Relaxation ◽  
Over Time

The effect of gastric branch vagotomy (GVX) on the gastric emptying of glucose was evaluated during two phases of emptying control: as the stomach fills and in the postload period. GVX and control rats received a series of intragastric glucose infusions (1.0 ml/min) through indwelling gastric fistulas. In experiment 1, gastric samples were withdrawn either immediately after the offset of 9- or 18-min infusions of 12.5% glucose or at various times up to 36 min postinfusion. In experiment 2, samples were withdrawn either immediately or 30 min after termination of 12-min infusions of 12.5 or 25% glucose. After gastric fill, glucose solute emptying rate was stable over time, not influenced by concentration doubling, and, surprisingly, not affected by GVX. During gastric fill, solute emptying rate doubled with concentration in both GVX and control rats. For each concentration, however, glucose emptied during fill at almost twice the rate in GVX compared with control rats. This accelerated emptying of glucose during fill in GVX rats is consistent with a gastric vagal contribution to inhibitory mechanisms (e.g., receptive relaxation) that operate as the stomach fills under normal conditions. The absence of a GVX effect on emptying after fill suggests either that gastric branch vagal efferents play little role in feedback inhibitory control of glucose emptying under normal conditions or that other systems compensate for the function previously served by vagal gastric branch efferents. Further work is required to address the possible role of the gastric vagus in feedback control of gastric emptying when nutritive fluids other than glucose are delivered.

scholarly journals Uterine Dysfunction in Diabetic Mice: The Role of Hydrogen Sulfide

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 917
Author(s):  
Emma Mitidieri ◽  
Domenico Vanacore ◽  
Carlotta Turnaturi ◽  
Raffaella Sorrentino ◽  
Roberta d’Emmanuele di Villa Bianca
Keyword(s):  
Hydrogen Sulfide ◽  
Cyclic Nucleotides ◽  
Nod Mice ◽  
Diabetic Mice ◽  
Uterine Contractions ◽  
Female Reproductive Health ◽  
Spontaneous Motility ◽  
Mercaptopyruvate Sulfurtransferase

It is well-known that the physiological uterine peristalsis, related to several phases of reproductive functions, plays a pivotal role in fertility and female reproductive health. Here, we have addressed the role of hydrogen sulfide (H2S) signaling in changes of uterine contractions driven by diabetes in non-obese diabetic (NOD) mice, a murine model of type-1 diabetes mellitus. The isolated uterus of NOD mice showed a significant reduction in spontaneous motility coupled to a generalized hypo-contractility to uterotonic agents. The levels of cyclic nucleotides, cAMP and cGMP, notoriously involved in the regulation of uterus homeostasis, were significantly elevated in NOD mouse uteri. This increase was well-correlated with the higher levels of H2S, a non-specific endogenous inhibitor of phosphodiesterases. The exposure of isolated uterus to L-cysteine (L-Cys), but not to sodium hydrogen sulfide, the exogenous source of H2S, showed a weak tocolytic effect in the uterus of NOD mice. Western blot analysis revealed a reorganization of the enzymatic expression with an upregulation of 3-mercaptopyruvate-sulfurtransferase (3-MST) coupled to a reduction in both cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) expression. In conclusion, the increased levels of cyclic nucleotides dysregulate the uterus peristalsis and contractility in diabetic mice through an increase in basal H2S synthesis suggesting a role of 3-MST.

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