scholarly journals Unknown low molecular weight iron‐peptide complexes and their possible contribution to the “labile iron pool” in mammalian cells

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Ben Rojas ◽  
Danny Ramos ◽  
Lina Planutyte ◽  
Vireak Thon ◽  
Andrew Z. Mason ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Mammalian Cells ◽  
Low Molecular Weight ◽  
Labile Iron Pool ◽  
Peptide Complexes ◽  
Labile Iron ◽  
Iron Pool ◽  
Low Molecular Weight Iron

Fluorescence Analysis of the Labile Iron Pool of Mammalian Cells

1997 ◽  
Vol 248 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Silvina Epsztejn ◽  
Or Kakhlon ◽  
Hava Glickstein ◽  
William Breuer ◽  
Z.Ioav Cabantchik
Keyword(s):  
Mammalian Cells ◽  
Fluorescence Analysis ◽  
Labile Iron Pool ◽  
Labile Iron ◽  
Iron Pool

scholarly journals Characterizing the chelatable/labile iron pool in mammalian cells

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Natasha Hill ◽  
Ben Rojas ◽  
Vireak Thon ◽  
Albert Beck ◽  
Lena Ton‐nu ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Labile Iron Pool ◽  
Labile Iron ◽  
Iron Pool

scholarly journals Analysis of yggX and gshA Mutants Provides Insights into the Labile Iron Pool in Salmonella enterica

2008 ◽  
Vol 190 (23) ◽  
pp. 7608-7613 ◽  
Author(s):  
Michael P. Thorgersen ◽  
Diana M. Downs
Keyword(s):  
Salmonella Enterica ◽  
Iron Chelator ◽  
Fenton Chemistry ◽  
Labile Iron Pool ◽  
Growth Defects ◽  
Labile Iron ◽  
Iron Pool ◽  
Mutant Phenotypes ◽  
Permeable Iron ◽  
Iron Chelator Deferoxamine

ABSTRACT Strains of Salmonella enterica lacking YggX and the cellular reductant glutathione exhibit defects similar to those resulting from iron deficiency and oxidative stress. Mutant strains are sensitive to hydrogen peroxide and superoxide, deregulate the expression of the Fur-regulated gene entB, and fail to grow on succinate medium. Suppression of some yggX gshA mutant phenotypes by the cell-permeable iron chelator deferoxamine allowed the conclusion that increased levels of cellular Fenton chemistry played a role in the growth defects. The data presented are consistent with a scenario in which glutathione acts as a physiological chelator of the labile iron pool and in which YggX acts upstream of the labile iron pool by preventing superoxide toxicity.

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