scholarly journals Angiotensin II‐induced migration of vascular smooth muscle cells (VSMCs) is mediated by both 72‐KDa spleen tyrosine kinase (Syk) via p38‐MAPK activated c‐Src and by ERK1/2 via c‐Src‐induced EGFR transactivation

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Benon Emmanuel Mugabe ◽  
Fariborz A Yaghini ◽  
Cuneyt K Buharalioglu ◽  
Kafait U Malik
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Tyrosine Kinase ◽  
Smooth Muscle Cells ◽  
P38 Mapk ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Spleen Tyrosine Kinase ◽  
Egfr Transactivation

Activation of Akt/protein kinase B after stimulation with angiotensin II in vascular smooth muscle cells

1999 ◽  
Vol 276 (6) ◽  
pp. H1927-H1934 ◽  
Author(s):  
Tomosaburo Takahashi ◽  
Takahiro Taniguchi ◽  
Hiroaki Konishi ◽  
Ushio Kikkawa ◽  
Yuichi Ishikawa ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Protein Kinase ◽  
Vascular Smooth Muscle ◽  
Tyrosine Kinase ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Protein Kinase B ◽  
Muscle Cells ◽  
Ang Ii

Involvement of Akt/Protein kinase B (PKB), a serine/threonine kinase with a pleckstrin-homology domain, in angiotensin II (ANG II)-induced signal transduction was investigated in cultured vascular smooth muscle cells (VSMC). Stimulation of the cells with ANG II led to a marked increase in the kinase activity of Akt/PKB, which coincided with Ser-473 phosphorylation. ANG II-stimulated Akt/PKB activation was rapid, concentration dependent, and inhibited by the AT1-receptor antagonist CV-11974, but not by pertussis toxin. Akt/PKB activity was stimulated by the Ca2+ ionophore ionomycin, suggesting the possible involvement of Ca2+ in ANG II-stimulated Akt/PKB activation. However, blockade of Ca2+ mobilization by BAPTA-AM only partially inhibited ANG II-stimulated Akt/PKB activation. ANG II-stimulated Akt/PKB activation was inhibited by the tyrosine kinase inhibitors genistein and herbimycin A and by the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY-294002. These results indicate that ANG II stimulates Akt/PKB activity via AT1 receptors in VSMC and that the activities of tyrosine kinase and PI3K are required for this activation.

scholarly journals Deletion of Jak2 Tyrosine Kinase within Vascular Smooth Muscle Cells Attenuates Angiotensin II induced Hypertension in Mice

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Annet Kirabo ◽  
Patrick Kearns ◽  
Jennifer Sasser ◽  
Arturo J Cardounel ◽  
Chris Baylis ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Tyrosine Kinase ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Induced Hypertension
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