scholarly journals REDUCED FUNCTIONALITY OF RENIN‐ANGIOTENSIN‐ALDOSTERONE SYSTEM IN YOUNG RATS EXPOSED TO HIGH‐SALT DIET

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Sandra Crestani ◽  
Arquimedes Garparotto ◽  
Maria Consuelo Andrade Marques ◽  
Jennifer C. Sullivan ◽  
R. Clinton Webb ◽  
...  
Keyword(s):  
High Salt ◽  
High Salt Diet ◽  
Renin Angiotensin Aldosterone System ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
Young Rats

scholarly journals High salt diet during pregnancy: effects on the renin ‐angiotensin‐aldosterone system in adult male offspring of Wistar rats

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Débora Rothstein Ramos ◽  
Nauilo L. Costa ◽  
Ivone B. Oliveira ◽  
Karen L. Lopes ◽  
Joel C. Heimann ◽  
...  
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
High Salt ◽  
Male Offspring ◽  
High Salt Diet ◽  
Renin Angiotensin Aldosterone System ◽  
Salt Diet ◽  
Renin Angiotensin

scholarly journals Effects of Sodium Glucose Cotransporter 2 Inhibitor on Renal Renin-Angiotensin-Aldsoterone System

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A439-A439
Author(s):  
Yoshiyu Takeda ◽  
Yoshimichi Takeda ◽  
Masashi Demura ◽  
Mitsuhiro Kometani ◽  
Shigehiro Karashima ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Rats ◽  
High Salt ◽  
Diabetic Patients ◽  
Mrna Levels ◽  
High Salt Diet ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
Sodium Glucose Cotransporter ◽  
And Control

Abstract Objective: The renoprotective effect of sodium glucose cotransporter 2 inhibitor (SGL2i) has been reported in diabetic patients. Local renin-angiotensin-aldosterone system (RAAS) is activated in diabetes mellitus and hypertension. We examined the effects of SGL2i on the RAAS in the obese diabetic rats fed a high salt diet. Methods: Zucker-diabetic rats (ZDR) and control rats were fed a high or normal salt diet and were treated with canagliflozin for 8 weeks. Blood pressure (BP), blood glucose (BG), PRA, plasma aldosterone (PAC), urinary albumin excretion (UAE), urinary 8-hydroxy-2’-deoxyguanosine (8-OHdG), gene expression of angiotensinogen in the kidney were measured. Results: ZDR febd a high salt diet showed high BP, increased UAE and urinary 8-OHdG and elevated angiotensinogen mRNA levels. Treatment with canagliflozin significantly decreased BP, BG, UAE, urinary 8-OHdG and and renal angiotensinogen mRNA levels compared with control rats (p&lt0.05). Discussion and Conclusion: The closer mechanism of renoptotection of SGL2i in diabetes mellitus is unclear. We have reported that the repoprotective effects of type 2 angiotensin receptor antagonist or mineralocorticoid receptor blocker were partly due to the decreased RAAS in the kidney. Decreased renal RAAS by the treatment with canagliflozin may contribute to the renoprotection in DZR.

scholarly journals Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet

2017 ◽  
Vol 6 (1) ◽  
pp. 29 ◽  
Author(s):  
Gabriel Cao ◽  
Silvana Lorena Della Penna ◽  
Nicolás Martín Kouyoumdzian ◽  
Marcelo Roberto Choi ◽  
Susana Gorzalczany ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
High Salt ◽  
Immunohistochemical Expression ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
System Components

Dietary Salt Modifies the Blood Pressure Response to Renin-Angiotensin Inhibition in Experimental Chronic Kidney Disease

2021 ◽  
Author(s):  
Dominique M Bovee ◽  
Estrellita Uijl ◽  
David Severs ◽  
Eloisa Rubio-Beltrán ◽  
Richard van Veghel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
High Salt ◽  
Dietary Salt ◽  
High Salt Diet ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
Water Accumulation ◽  
Salt Sensitive Hypertension

Chronic kidney disease (CKD) contributes to hypertension, but the mechanisms are incompletely understood. To address this, we applied the 5/6th nephrectomy rat model to characterize hypertension and the response to dietary salt and renin-angiotensin inhibition. 5/6th nephrectomy caused low-renin, salt-sensitive hypertension with hyperkalemia and unsuppressed aldosterone. Compared to sham, 5/6Nx rats had lower NHE3, NKCC2, NCC, a-ENaC and Kir4.1, but higher SKG1, prostasin, g-ENaC, and Kir5.1. These differences correlated with plasma renin, aldosterone, and/or potassium. On a normal salt diet, adrenalectomy (0 ± 9 mmHg) and spironolactone (-11 ± 10 mmHg) prevented a progressive rise in blood pressure (10 ± 8 mmHg), and this was enhanced in combination with losartan (-41 ± 12 mmHg and -43 ± 9 mmHg). A high salt diet caused skin sodium and water accumulation and aggravated hypertension that could only be attenuated by spironolactone (-16 ± 7 mmHg) and in which the additive effect of losartan was lost. Spironolactone also increased natriuresis, reduced skin water accumulation and restored vasorelaxation. In summary, in the 5/6th nephrectomy rat CKD model, salt-sensitive hypertension develops with a selective increase in g-ENaC and despite appropriate transporter adaptations to low renin and hyperkalemia. With a normal salt diet, hypertension in 5/6th nephrectomy depends on angiotensin II and aldosterone, while a high salt diet causes more severe hypertension mediated through the mineralocorticoid receptor.

scholarly journals Effects of Renin-Angiotensin System Inhibitors on Renal Expression of Renalase in Sprague-Dawley Rats Fed With High Salt Diet

2015 ◽  
Vol 40 (6) ◽  
pp. 605-613 ◽  
Author(s):  
Yang Wang ◽  
Bing-Qing Xie ◽  
Wei-Hua Gao ◽  
Ding-Yi Yan ◽  
Wen-Ling Zheng ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
High Salt ◽  
Sprague Dawley ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
Sprague Dawley Rats ◽  
Renal Expression

Prenatal high-salt diet impaired vasodilatation with reprogrammed renin–angiotensin system in offspring rats

2018 ◽  
Vol 36 (12) ◽  
pp. 2369-2379 ◽  
Author(s):  
Yanping Liu ◽  
Linglu Qi ◽  
Jue Wu ◽  
Ting Xu ◽  
Chunli Yang ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
High Salt ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin

scholarly journals Renal responses to three types of renin–angiotensin system blockers in patients with diabetes mellitus on a high-salt diet

2011 ◽  
Vol 29 (12) ◽  
pp. 2454-2461 ◽  
Author(s):  
Norman K. Hollenberg ◽  
Naomi D.L. Fisher ◽  
Juerg Nussberger ◽  
George V. Moukarbel ◽  
Ebrahim Barkoudah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renin Angiotensin System ◽  
High Salt ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin ◽  
Patients With Diabetes ◽  
Renal Responses ◽  
Renin Angiotensin System Blockers

scholarly journals High-Salt Diet and Hypertension: Focus on the Renin-Angiotensin System

2011 ◽  
Vol 34 (1) ◽  
pp. 1-11 ◽  
Author(s):  
I. Drenjančević-Perić ◽  
B. Jelaković ◽  
J.H. Lombard ◽  
M.P. Kunert ◽  
A. Kibel ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
High Salt ◽  
High Salt Diet ◽  
Angiotensin System ◽  
Salt Diet ◽  
Renin Angiotensin
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