scholarly journals Sca‐1 positive pancreatic progenitor cells as a cell transplant therapy for treatment of Diabetes Mellitus

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Lisa Lynn Samuelson ◽  
David Gerber
Keyword(s):  
Diabetes Mellitus ◽  
Progenitor Cells ◽  
Cell Transplant ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells ◽  
A Cell ◽  
Treatment Of Diabetes

scholarly journals Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells

2017 ◽  
Vol 24 ◽  
pp. 61-68 ◽  
Author(s):  
Azuma Kimura ◽  
Taro Toyoda ◽  
Yohei Nishi ◽  
Makoto Nasu ◽  
Akira Ohta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Progenitor Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells

scholarly journals Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device

2016 ◽  
Vol 100 (6) ◽  
pp. 1211-1218 ◽  
Author(s):  
Gaetano Faleo ◽  
Karim Lee ◽  
Vinh Nguyen ◽  
Qizhi Tang
Keyword(s):  
Progenitor Cells ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells

scholarly journals Human Fetal Bone Marrow-Derived Mesenchymal Stem Cells Promote the Proliferation and Differentiation of Pancreatic Progenitor Cells and the Engraftment Function of Islet-Like Cell Clusters

2019 ◽  
Vol 20 (17) ◽  
pp. 4083
Author(s):  
Xing Yu Li ◽  
Shang Ying Wu ◽  
Po Sing Leung
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Progenitor Cells ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells ◽  
Proliferation And Differentiation ◽  
Differentiation And Proliferation

Pancreatic progenitor cells (PPCs) are the primary source for all pancreatic cells, including beta-cells, and thus the proliferation and differentiation of PPCs into islet-like cell clusters (ICCs) opens an avenue to providing transplantable islets for diabetic patients. Meanwhile, mesenchymal stem cells (MSCs) can enhance the development and function of different cell types of interest, but their role on PPCs remains unknown. We aimed to explore the mechanism-of-action whereby MSCs induce the in vitro and in vivo PPC/ICC development by means of our established co-culture system of human PPCs with human fetal bone marrow-derived MSCs. We examined the effect of MSC-conditioned medium on PPC proliferation and survival. Meanwhile, we studied the effect of MSC co-culture enhanced PPC/ICC function in vitro and in vivo co-/transplantation. Furthermore, we identified IGF1 as a critical factor responsible for the MSC effects on PPC differentiation and proliferation via IGF1-PI3K/Akt and IGF1-MEK/ERK1/2, respectively. In conclusion, our data indicate that MSCs stimulated the differentiation and proliferation of human PPCs via IGF1 signaling, and more importantly, promoted the in vivo engraftment function of ICCs. Taken together, our protocol may provide a mechanism-driven basis for the proliferation and differentiation of PPCs into clinically transplantable islets.

scholarly journals Genetic Modification of Primate Amniotic Fluid-Derived Stem Cells Produces Pancreatic Progenitor Cells in vitro

2013 ◽  
Vol 197 (4) ◽  
pp. 269-282 ◽  
Author(s):  
Yu Zhou ◽  
David L. Mack ◽  
J. Koudy Williams ◽  
Sayed-Hadi Mirmalek-Sani ◽  
Emily Moorefield ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Progenitor Cells ◽  
Genetic Modification ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells

scholarly journals Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

Stem Cells ◽  
2013 ◽  
Vol 31 (11) ◽  
pp. 2432-2442 ◽  
Author(s):  
Alireza Rezania ◽  
Jennifer E. Bruin ◽  
Jean Xu ◽  
Kavitha Narayan ◽  
Jessica K. Fox ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Progenitor Cells ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells ◽  
Insulin Secreting Cells
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