scholarly journals Analysis of cyclic AMP‐coupled signature molecules in human micro vascular smooth muscle cells shows link to stress‐associated proteins

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Selvi C Jeyaraj ◽  
Nicholas T Unger ◽  
N. Paul El‐Dahdah ◽  
Richard J Sessler ◽  
Matthew Zirwas ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cyclic Amp ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Associated Proteins

scholarly journals Agents which increase cyclic AMP have diverse effects on low-density-lipoprotein-receptor function in human vascular smooth-muscle cells and skin fibroblasts

1990 ◽  
Vol 267 (3) ◽  
pp. 607-614 ◽  
Author(s):  
A Middleton ◽  
B Middleton
Keyword(s):  
Smooth Muscle ◽  
Cyclic Amp ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Ldl Receptor ◽  
Muscle Cells ◽  
Skin Fibroblasts ◽  
Receptor Expression ◽  
Low Density

Receptor-mediated binding and metabolism of low-density lipoproteins (LDL) in cultured human vascular smooth-muscle cells and skin fibroblasts are altered by increased cellular cyclic AMP concentrations. However, the LDL receptor does not respond to changes in cyclic AMP concentration in a simple manner. The activation of adenylate cyclase with forskolin, or the addition of membrane-permeant cyclic AMP analogues, initially decreases the expression of the LDL receptor, but is followed by a substantial increase in receptor expression after 24 h. This increase does not occur in the presence of inhibitors of RNA or protein synthesis, and is due to doubling of the Bmax. of the LDL receptor, without alteration of its affinity for LDL. By contrast, elevation of cyclic AMP concentration by inhibition of phosphodiesterases results in decreased receptor expression throughout the 24 h period. These two response patterns are reproducible phenomena, consistently observed in low-passaged cells derived from seven unrelated individuals.

scholarly journals Apoptosis Induced by Inhibition of Cyclic AMP Response Element–Binding Protein in Vascular Smooth Muscle Cells

Circulation ◽  
2003 ◽  
Vol 108 (10) ◽  
pp. 1246-1252 ◽  
Author(s):  
Tomotake Tokunou ◽  
Rei Shibata ◽  
Hisashi Kai ◽  
Toshihiro Ichiki ◽  
Takashi Morisaki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cyclic Amp ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Binding Protein ◽  
Muscle Cells ◽  
Response Element ◽  
Element Binding Protein ◽  
Cyclic Amp Response Element

Influences of Ca2+ : Antagonist and Cyclic AMP on Vascular Smooth Muscle Cells in Culture

Angiology ◽  
1985 ◽  
Vol 36 (9) ◽  
pp. 622-627
Author(s):  
Fumio Kuzuya ◽  
Michitaka Naito ◽  
Kan-ichi Asai ◽  
Kazuaki Shibata
Keyword(s):  
Smooth Muscle ◽  
Cyclic Amp ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Cells In Culture
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