scholarly journals Regulation of ATP Binding Cassette Transporter A1 (ABCA1) and ABCG1 by Fatty Acids in RAW 264.7 Macrophages

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Chai Siah Ku ◽  
Young‐Ki Park ◽  
Sara L Coleman ◽  
Jeong Min Seo ◽  
Ji‐Young Lee
Keyword(s):  
Fatty Acids ◽  
Atp Binding ◽  
Raw 264.7 ◽  
Raw 264.7 Macrophages ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

scholarly journals Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells

2011 ◽  
Vol 31 (4) ◽  
pp. 278-285 ◽  
Author(s):  
Chai Siah Ku ◽  
Heather E. Rasmussen ◽  
Youngki Park ◽  
Elliot D. Jesch ◽  
Jiyoung Lee
Keyword(s):  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

scholarly journals Liver-X-receptor-mediated increase in ATP-binding cassette transporter A1 expression is attenuated by fatty acids in CaCo- cells: effect on cholesterol efflux to high-density lipoprotein

2004 ◽  
Vol 377 (3) ◽  
pp. 545-552 ◽  
Author(s):  
Shubha MURTHY ◽  
Ella BORN ◽  
Satya N. MATHUR ◽  
F. Jeffrey FIELD
Keyword(s):  
Fatty Acids ◽  
Oleic Acid ◽  
Cholesterol Efflux ◽  
Atp Binding ◽  
Transcriptional Level ◽  
Mrna Levels ◽  
Atp Binding Cassette Transporter ◽  
Arachidonic Acids ◽  
Docosahexaenoic Acids ◽  
Atp Binding Cassette

The effect of fatty acids on LXR (liver X receptors)-mediated enhancement of ABCA1 (ATP-binding cassette transporter A1) expression and cholesterol efflux was investigated in human intestinal cells CaCo-2. LXR activation by T0901317 increased basolateral cholesterol efflux to lipoprotein particles isolated at a density of 1.21 g/ml or higher. Oleic and arachidonic acids attenuated the amount of cholesterol isolated from these particles. Stearic, linoleic and docosahexaenoic acids also decreased cholesterol efflux from basolateral membranes, with the polyunsaturated fatty acids being the most potent. Although oleic, arachidonic and docosahexaenoic acids modestly decreased ABCA1 mRNA levels in response to LXR activation, stearic and linoleic acids did not. Except for oleic acid, all fatty acids substantially attenuated an increase in ABCA1 mass secondary to LXR activation. Inhibiting acyl-CoA:cholesterol acyltransferase activity prevented the decrease in cholesterol efflux caused by oleic acid. Thus, in response to LXR activation, all fatty acids decreased the efflux of cholesterol from the basolateral membrane of CaCo-2 cells. Although modest suppression of ABCA1 gene expression by oleic, arachidonic and docosahexaenoic acids cannot be completely excluded as a mechanism, the predominant effect of fatty acids on ABCA1 expression and cholesterol efflux is at a post-transcriptional level.

scholarly journals Polyunsaturated Fatty Acids and Acetoacetate Downregulate the Expression of the ATP-Binding Cassette Transporter A1

Diabetes ◽  
2002 ◽  
Vol 51 (10) ◽  
pp. 2922-2928 ◽  
Author(s):  
Y. Uehara ◽  
T. Engel ◽  
Z. Li ◽  
C. Goepfert ◽  
S. Rust ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette
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