scholarly journals Effect of Natural Plant Water Extracts Suppressed Melanin Production in B16 Mouse Melanoma Cell

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Tae Hyuk Kim ◽  
Mi Ja Chung ◽  
Dae Jung Kim ◽  
Jin Kyoun You ◽  
Dong Joo Seo ◽  
...  
2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Jung Yeong Jang ◽  
Mi Ja Chung ◽  
Jin kyoun You ◽  
Dae Jung Kim ◽  
Dong Joo Seo ◽  
...  

BMC Cancer ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Osamu Hashimoto ◽  
Masako Shinkawa ◽  
Takuji Torimura ◽  
Toru Nakamura ◽  
Karuppaiyah Selvendiran ◽  
...  

2013 ◽  
Vol 30 (1) ◽  
pp. 260-268 ◽  
Author(s):  
FENGLI WANG ◽  
QIONGSHU LI ◽  
WEIHUA NI ◽  
FANG FANG ◽  
XIAXIA SUN ◽  
...  

2002 ◽  
Vol 25 (6) ◽  
pp. 885-888 ◽  
Author(s):  
Soo Min Cho ◽  
Young Min Kwon ◽  
Jae Hee Lee ◽  
Kyu Hyeong Yon ◽  
Min Won Lee

Author(s):  
Irit Gil-Ad ◽  
Biana Shtaif ◽  
Yechiel Levkovitz ◽  
Jardena Nordenberg ◽  
Michal Taler ◽  
...  

2004 ◽  
Vol 1030 (1) ◽  
pp. 384-392 ◽  
Author(s):  
LELA B. KORIĆANAC ◽  
DANIJELA V. TODOROVIĆ ◽  
NATAŠA M. POPOVIĆ ◽  
MIROSLAV A. DEMAJO ◽  
SABERA D. RUŽDIJIĆ ◽  
...  

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Jin Kyoun You ◽  
Dong Joo Seo ◽  
Dae Jung Kim ◽  
Mi Ja Chung ◽  
Jeong Hae Park ◽  
...  

1995 ◽  
Vol 5 ◽  
pp. 16
Author(s):  
B. Loir ◽  
M-C. Carrière ◽  
G. Ghanem ◽  
J. Drouin ◽  
L. Roselli-Rehfuss

2020 ◽  
Vol 25 (1) ◽  
pp. 83-91
Author(s):  
Maryam Malek ◽  
◽  
Maedeh Ghasemi ◽  
Golnaz Vaseghi ◽  
Ahmad Ghasemi ◽  
...  

Introduction: Tamoxifen has been used in the treatment of metastatic malignant melanoma more common with other agents in the combined therapy. Up-regulated activity of the mevalonate pathway has been shown in a range of different cancers. Atorvastatin is the most commonly used statin approved for cholesterol reduction by inhibiting the mevalonate pathway and has been shown to inhibit tumor growth. In the present study, we used atorvastatin and tamoxifen combination therapy on B16f10 mouse melanoma cell lines to study whether atorvastatin could increase the sensitivity of melanoma cells to the chemotherapeutic agent such as tamoxifen. Methods: The cell line was treated with different concentrations of tamoxifen and/or atorvastatin for 24 and 48h and the effects of treatment on p53 and RhoA were investigated using quantitative RT-PCR. Results: The combination of atorvastatin and tamoxifen resulted in a potentiation antitumor effect via up-regulation of p53 and down-regulation of RhoA expression against melanoma tumors in vitro. Furthermore, we demonstrated the combination of atorvastatin with tamoxifen could reduce tamoxifen dose to minimize possible detrimental side effects in melanoma. Conclusion: Our results suggested that atorvastatin as a combined therapy with tamoxifen may provide a new approach for improving the efficacy and treating against melanoma cancer but needs further exploration in clinical trials.


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