scholarly journals Role of nuclear factor‐kappa B in mitochondria‐derived superoxide‐lowered protein expression of voltage‐gated sodium channels in nodose neurons from heart failure rats

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Huiyin Tu ◽  
Jinxu Liu ◽  
Yu-long Li
Keyword(s):  
Heart Failure ◽  
Protein Expression ◽  
Sodium Channels ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Voltage Gated ◽  
Nuclear Factor Kappa ◽  
Voltage Gated Sodium Channels

The role of nuclear factor-[kappa ]B in the biology and treatment of multiple myeloma

2001 ◽  
Vol 28 (6) ◽  
pp. 626-633 ◽  
Author(s):  
James R. Berenson ◽  
Hongjin M. Ma ◽  
Robert Vescio
Keyword(s):  
Multiple Myeloma ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth

Oral Diseases ◽  
2013 ◽  
Vol 20 (3) ◽  
pp. 294-300 ◽  
Author(s):  
T Arabaci ◽  
O Köse ◽  
A Kizildağ ◽  
M Albayrak ◽  
Y Çiçek ◽  
...  
Keyword(s):  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Gingival Overgrowth ◽  
Nuclear Factor Kappa

scholarly journals Mining the Virgin Land of Neurotoxicology: A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Zhirui Liu ◽  
Jie Tao ◽  
Pin Ye ◽  
Yonghua Ji
Keyword(s):  
Sodium Channels ◽  
Network Activity ◽  
Voltage Gated ◽  
Virgin Land ◽  
Neuronal Network Activity ◽  
Voltage Gated Sodium Channels ◽  
Pharmacological Targets ◽  
Underlying Mechanisms ◽  
Posttranslation Modification

Voltage-gated sodium channels (VGSCs) are important membrane protein carrying on the molecular basis for action potentials (AP) in neuronal firings. Even though the structure-function studies were the most pursued spots, the posttranslation modification processes, such as glycosylation, phosphorylation, and alternative splicing associating with channel functions captured less eyesights. The accumulative research suggested an interaction between the sialic acids chains and ion-permeable pores, giving rise to subtle but significant impacts on channel gating. Sodium channel-specific neurotoxic toxins, a family of long-chain polypeptides originated from venomous animals, are found to potentially share the binding sites adjacent to glycosylated region on VGSCs. Thus, an interaction between toxin and glycosylated VGSC might hopefully join the campaign to approach the role of glycosylation in modulating VGSCs-involved neuronal network activity. This paper will cover the state-of-the-art advances of researches on glycosylation-mediated VGSCs function and the possible underlying mechanisms of interactions between toxin and glycosylated VGSCs, which may therefore, fulfill the knowledge in identifying the pharmacological targets and therapeutic values of VGSCs.

The Role of Nonprotein Domains in the Function and Synthesis of Voltage-Gated Sodium Channels

Ion Channels ◽  
1990 ◽  
pp. 33-64 ◽  
Author(s):  
S. R. Levinson ◽  
W. B. Thornhill ◽  
D. S. Duch ◽  
E. Recio-Pinto ◽  
B. W. Urban
Keyword(s):  
Sodium Channels ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels

scholarly journals Role of nuclear factor kappa B in central nervous system regeneration

2014 ◽  
Vol 9 (7) ◽  
pp. 707 ◽  
Author(s):  
Ronny Haenold ◽  
Christian Engelmann ◽  
Falk Weih
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

Dysregulated nuclear factor kappa B (NF-kB) dependent apoptosis predicts a point of functional no return in hypertrophic heart failure

2008 ◽  
Vol 207 (3) ◽  
pp. S28
Author(s):  
Nancy C. Moss ◽  
Peter Charles ◽  
Ru-hang Tang ◽  
Monte Willis ◽  
William E. Stansfield ◽  
...  
Keyword(s):  
Heart Failure ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa
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