scholarly journals Involvement of nuclear factor‐kappa B in superoxide‐lowered protein expression of voltage‐gated sodium channels in nodose ganglia from heart failure rats

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Huiyin Tu ◽  
Jinxu Liu ◽  
Dongze Zhang ◽  
Robert Muelleman ◽  
Yulong Li
Keyword(s):  
Heart Failure ◽  
Protein Expression ◽  
Sodium Channels ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Voltage Gated ◽  
Nuclear Factor Kappa ◽  
Voltage Gated Sodium Channels ◽  
Nodose Ganglia

Dysregulated nuclear factor kappa B (NF-kB) dependent apoptosis predicts a point of functional no return in hypertrophic heart failure

2008 ◽  
Vol 207 (3) ◽  
pp. S28
Author(s):  
Nancy C. Moss ◽  
Peter Charles ◽  
Ru-hang Tang ◽  
Monte Willis ◽  
William E. Stansfield ◽  
...  
Keyword(s):  
Heart Failure ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

scholarly journals Reduced expression and activation of voltage-gated sodium channels contributes to blunted baroreflex sensitivity in heart failure rats

2010 ◽  
Vol 88 (15) ◽  
pp. 3337-3349 ◽  
Author(s):  
Huiyin Tu ◽  
Libin Zhang ◽  
Thai P. Tran ◽  
Robert L. Muelleman ◽  
Yu-Long Li
Keyword(s):  
Heart Failure ◽  
Sodium Channels ◽  
Baroreflex Sensitivity ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels

scholarly journals MyD88 determines the protective effects of fish oil and perilla oil against metabolic disorders and inflammation in adipose tissue from mice fed a high-fat diet

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Feng Wang ◽  
Mingyuan Hu ◽  
Hangju Zhu ◽  
Chao Yang ◽  
Hui Xia ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Protein Expression ◽  
Metabolic Disorders ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Protective Effects ◽  
High Fat ◽  
Beneficial Effects ◽  
Nuclear Factor Kappa ◽  
Mrna And Protein Expression

Abstract Background The beneficial effects of ω−3 polyunsaturated fatty acids (PUFA) vary between different sources. However, there is a paucity of comparative studies regarding the effects and mechanisms of marine and plant ω−3 PUFA on obesity. Objective The aim of this study was to evaluate the effects of fish oil (FO) and perilla oil (PO) on glucolipid metabolism, inflammation, and adipokine in mice fed a high-fat (HF) diet in association with the contribution of toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88) pathway. Methods C57BL/6J mice and MyD88−/− mice were randomly divided into 4 groups: normal chow diet, HF diet, HF diet accompanied by daily gavage with either FO or PO. After 4 weeks, blood biochemistries, adipocyte histology, mRNA, and protein expression of MyD88-dependent and -independent pathways of TLR4 signaling in epididymal adipose tissue were measured. Results In C57BL/6J mice, there were no statistical differences between FO and PO in decreasing body weight, glucose, insulin, triglyceride, total cholesterol, interleukin-6, and increasing adipocyte counts. FO and PO decreased mRNA and protein expression of TLR4, MyD88, tumor necrosis factor receptor-associated factor 6, inhibitor of nuclear factor kappa B kinase beta and nuclear factor-kappa B p65. In MyD88−/− mice, the beneficial effects of FO and PO on HF diet-induced metabolism abnormalities and inflammation were abolished. FO and PO had no impacts on mRNA and protein expression of receptor-interacting protein-1, interferon regulate factor 3, and nuclear factor-kappa B p65. Conclusion FO and PO exhibit similar protective effects on metabolic disorders and inflammation through inhibiting TLR4 signaling in a manner dependent on MyD88. These findings highlight plant ω−3 PUFA as an attractive alternative source of marine ω−3 PUFA and reveal a mechanistic insight for preventive benefits of ω−3 PUFA in obesity and related metabolic diseases.

scholarly journals Lowered activation of voltage‐gated sodium channels contributes to blunted baroreflex sensitivity in heart failure rats

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Huiyin Tu ◽  
Libin Zhang ◽  
Thai P. Tran ◽  
Robert L. Muelleman ◽  
Yu‐Long Li
Keyword(s):  
Heart Failure ◽  
Sodium Channels ◽  
Baroreflex Sensitivity ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels
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