scholarly journals Cranberry ( Vaccinium macrocarpon ) extract inhibits matrix metalloproteinase expression in aortic smooth muscle cells by affecting key cell signaling pathways (934.1)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Robert Hurta ◽  
Amanda Thomas ◽  
Joseph Kim ◽  
Kunal Patel ◽  
Catherine Neto
Keyword(s):  
Smooth Muscle ◽  
Matrix Metalloproteinase ◽  
Smooth Muscle Cells ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Muscle Cells ◽  
Vaccinium Macrocarpon ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Cell Signaling Pathways

scholarly journals Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9

2008 ◽  
Vol 100 (4) ◽  
pp. 731-738 ◽  
Author(s):  
Ya-Mei Yu ◽  
Hsing-Chun Lin ◽  
Weng-Cheng Chang
Keyword(s):  
Reactive Oxygen Species ◽  
Smooth Muscle ◽  
Matrix Metalloproteinase ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Carnosic Acid ◽  
Oxygen Species ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Tnf Α

The migration and matrix metalloproteinase (MMP) activation of vascular smooth muscle cells may play key roles in the development of atherosclerosis. Carnosic acid (CA) is a phenolic compound found in herbs, including rosemary and sage. Previous studies indicated that CA possesses antioxidant activity in vitro. In this study, we investigated the effects of CA on TNF-α-induced cell migration, the formation of intracellular reactive oxygen species, the translocation of NF-κB and the activation and expression of MMP-9 in human aortic smooth muscle cells (HASMC). The Matrigel migration assay showed that CA (10 and 20 μmol/l) effectively inhibited TNF-α-induced migration of HASMC as compared with the control group. To explain this inhibitory effect, MMP-9 was assayed by gelatin zymography and Western blot. The results indicated that CA inhibited MMP-9 activity and expression. Furthermore, the production of reactive oxygen species and the nuclear translocation of NF-κB p50 and p65 induced by TNF-α were dose-dependently suppressed by CA pretreament. These results indicate that CA has anti-inflammatory properties and may prevent the migration of HASMC by suppressing MMP-9 expression through down-regulation of NF-κB.

scholarly journals Distinctive molecular signature and activated signaling pathways in aortic smooth muscle cells of patients with myocardial infarction

2018 ◽  
Vol 271 ◽  
pp. 237-244 ◽  
Author(s):  
Thidathip Wongsurawat ◽  
Chin Cheng Woo ◽  
Antonis Giannakakis ◽  
Xiao Yun Lin ◽  
Esther Sok Hwee Cheow ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Signaling Pathways ◽  
Muscle Cells ◽  
Molecular Signature ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

Age-related changes in matrix metalloproteinase-9 regulation in cultured mouse aortic smooth muscle cells

2004 ◽  
Vol 39 (1) ◽  
pp. 123-131 ◽  
Author(s):  
Sung-Kwon Moon ◽  
Byung-Yoon Cha ◽  
Young-Choon Lee ◽  
Kyung-Soo Nam ◽  
Marschall S Runge ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Matrix Metalloproteinase ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Matrix Metalloproteinase 9 ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Age Related ◽  
Metalloproteinase 9 ◽  
Age Related Changes
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