Mechanical stretch promotes matrix metalloproteinase-2 and prolyl-4-hydroxylase α1 production in human aortic smooth muscle cells via Akt-p38 MAPK-JNK signaling

2015 ◽  
Vol 62 ◽  
pp. 15-23 ◽  
Author(s):  
Xinxin Liu ◽  
Xiaozhen Huang ◽  
Liang Chen ◽  
Yu Zhang ◽  
Mengmeng Li ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Matrix Metalloproteinase ◽  
Smooth Muscle Cells ◽  
P38 Mapk ◽  
Muscle Cells ◽  
Mechanical Stretch ◽  
Matrix Metalloproteinase 2 ◽  
Jnk Signaling ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

Fingerprint of long non-coding RNA regulated by cyclic mechanical stretch in human aortic smooth muscle cells: implications for hypertension

2017 ◽  
Vol 435 (1-2) ◽  
pp. 163-173 ◽  
Author(s):  
Laura-Eve Mantella ◽  
Krishna K. Singh ◽  
Paul Sandhu ◽  
Crystal Kantores ◽  
Azza Ramadan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mechanical Stretch ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9

2008 ◽  
Vol 100 (4) ◽  
pp. 731-738 ◽  
Author(s):  
Ya-Mei Yu ◽  
Hsing-Chun Lin ◽  
Weng-Cheng Chang
Keyword(s):  
Reactive Oxygen Species ◽  
Smooth Muscle ◽  
Matrix Metalloproteinase ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Carnosic Acid ◽  
Oxygen Species ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Tnf Α

The migration and matrix metalloproteinase (MMP) activation of vascular smooth muscle cells may play key roles in the development of atherosclerosis. Carnosic acid (CA) is a phenolic compound found in herbs, including rosemary and sage. Previous studies indicated that CA possesses antioxidant activity in vitro. In this study, we investigated the effects of CA on TNF-α-induced cell migration, the formation of intracellular reactive oxygen species, the translocation of NF-κB and the activation and expression of MMP-9 in human aortic smooth muscle cells (HASMC). The Matrigel migration assay showed that CA (10 and 20 μmol/l) effectively inhibited TNF-α-induced migration of HASMC as compared with the control group. To explain this inhibitory effect, MMP-9 was assayed by gelatin zymography and Western blot. The results indicated that CA inhibited MMP-9 activity and expression. Furthermore, the production of reactive oxygen species and the nuclear translocation of NF-κB p50 and p65 induced by TNF-α were dose-dependently suppressed by CA pretreament. These results indicate that CA has anti-inflammatory properties and may prevent the migration of HASMC by suppressing MMP-9 expression through down-regulation of NF-κB.

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