Cutaneous Histopathologic Features in Weanling Pigs After Exposure to Three Different Doses of Liquid Sulfur Mustard

1996 ◽  
Vol 18 (5) ◽  
pp. 515-520 ◽  
Author(s):  
Kathleen J. Smith ◽  
Henry G. Skelton ◽  
David W. Hobson ◽  
Franses M. Reid ◽  
James A. Blank ◽  
...  
1997 ◽  
Vol 14 (2) ◽  
pp. 126-135 ◽  
Author(s):  
Kathleen J. Smith ◽  
Robert Casillas ◽  
John Graham ◽  
Henry G. Skelton ◽  
Fred Stemler ◽  
...  

2015 ◽  
Vol 232 (1) ◽  
pp. 68-78 ◽  
Author(s):  
Stéphane Mouret ◽  
Julien Wartelle ◽  
Mohamed Batal ◽  
Sandy Emorine ◽  
Marine Bertoni ◽  
...  

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Muhammad Farid ◽  
Eryati Darwin ◽  
Delmi Sulastri

AbstrakDiabetes mellitus menjadi ancaman global yang bersifat serius dengan prevalensi yang terus meningkat. Banyaknya teori patogenesis dan perjalanan penyakit yang melibatkan interaksi kompleks banyak faktor menyebabkan pendekatan terapi diabetes masih berpusat pada tindakan preventif dan diagnosis diabetes ditegakkan sepenuhnya dari ada atau tidaknya hiperglikemia. Penelitian ini bertujuan untuk mengetahui pengaruh hiperglikemia terhadap gambaran histopatologis pulau Langerhans mencit. Dua puluh empat (24) mencit Swiss Albino jantan dibagi dalam empat kelompok: satu kelompok kontrol (K) dan tiga kelompok perlakuan (G1, G2, G3). Kelompok perlakuan diinduksi untuk mengalami hiperglikemia melalui pemberian glukosa intraperitoneal dengan dosis berbeda (G1=2g/kgBB, G2=4g/kgBB, G3=6g/kgBB) selama 14 hari. Hasil analisis morfometrik menunjukan bahwa luas dan diameter pulau Langerhans meningkat pada kelompok G1 (p<0.01) namun menurun pada kelompok G2 (p<0.01) dan G3 (p<0.05). Jumlah sel endokrin pulau Langerhans meningkat pada kelompok G2 (p<0.05) dan G3 (p<0.01). Akan tetapi, tidak ada perbedaan yang bermakna pada jumlah sel endokrin pulau Langerhans pada kelompok K dan G1 (p>0.05). Densitas pulau Langerhans meningkat pada seluruh kelompok perlakuan (p<0.05) melalui mekanisme neogenesis. Kesimpulan penelitian ini adalah hiperglikemia yang diinduksi lewat pemberian glukosa secara intraperitoneal menyebabkan perubahan yang signifikan pada gambaran histopatologis pulau Langerhans mencit.Kata kunci: hiperglikemia, pulau Langerhans, gambaran histopatologisAbstractDiabetes mellitus become a serious health threat which prevalence have been increasing steadily all over the world. With complex interactions of risk factors on the disease, therapeutic approach of diabetes still centered on preventive measures and diagnosis was made entirely from the presence of hyperglycemia. The objective of this study was to determine the effect of hyperglycemia on histopathological features of islet of Langerhans, we examined pancreatic tissues from 24 male Swiss Albino mice: 6 control (K) and 18 glucose-treated mice with 3 different doses (G1=2g/kg, G2=4g/kg, G3=6g/kg) for 14 days to induce hyperglycemia. Morphometric analysis of islet of Langerhans on H&E-stained pancreatic sections showed that the islet area and diameter were increased in group G1 (48607.13 μm2 and 240713.25 nm, respectively; p<0.01) but decreased in group G2 (5471.42 μm2 and 81170.83 nm, p<0.01) and G3 (4628.07 μm2 and 74730.86 nm, p<0.05). The islet cells count was increased in group G2 (210.33 ± 18.66 cells/islet, p<0.05) and G3 (264.17 ± 75.52 cells/islet, p<0.01). However, there was no significant difference on islet cells count between group K and group G1 (p>0.05). Islet density was slightly increased in all treated group (p<0.05) through mechanism of neogenesis. The result suggest that hyperglycemia induced by administration of different doses of glucose intraperitoneally for 14 days caused significant changes in histopathological features of mice pancreatic islet.Keywords: hyperglycemia, islet of Langerhans,histopathologic features


2005 ◽  
Vol 24 (3) ◽  
pp. 177-185 ◽  
Author(s):  
James V. Rogers ◽  
Jonathon W. Kohne ◽  
Timothy L. Hayes ◽  
Frances M. Reid ◽  
John S. Graham

1995 ◽  
Vol 22 (3) ◽  
pp. 260-268 ◽  
Author(s):  
K.J. Smith ◽  
J.S. Graham ◽  
R.B. Moeller ◽  
C.V. Okerberg ◽  
H. Skelton ◽  
...  

2007 ◽  
Vol 172 (2) ◽  
pp. 196-198 ◽  
Author(s):  
Jonathan Newmark ◽  
Janice M. Langer ◽  
Benedict Capacio ◽  
John Barr ◽  
Roger G. McIntosh
Keyword(s):  

2001 ◽  
Vol 37 (6) ◽  
pp. 653-656 ◽  
Author(s):  
Kurt G. Davis ◽  
Gary Aspera
Keyword(s):  

2001 ◽  
Vol 20 (S1) ◽  
pp. S161-S172 ◽  
Author(s):  
John S. Graham ◽  
Frances M. Reid ◽  
J. Richard Smith ◽  
Richard R. Stotts ◽  
F. Steven Tucker ◽  
...  

2020 ◽  
Vol 4 (2) ◽  
pp. 131-159

After the defeat of Iraqi army in Kuwait in February 1991, on April 3, the UN Security Council (UN Security Council) adopted Resolution 687, that «decides that Iraq shall unconditionally accept the destruction, removal, or rendering harmless, under international supervision, of: (a) All chemical and biological weapons and all stocks of agents and all related subsystems and components and all research, development, support and manufacturing facilities». This UN operation was not the first forced disarmament of vanquished by victors, but it gave great impetus to the completion of the work on the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction, i.e. the destruction of an entire class of weapons of mass destruction. The aim of this article was to show the process of Iraqi`s chemical weapons destruction. The destruction of Iraqi chemical weapons included the formation of legal basis (United Nations Security Council Resolution 687); the establishment of the United Nations Special Commission (UNSCOM) to inspect and oversee the destruction or elimination of Iraq’s chemical weapons directly on Iraqi territory; certain measures of political, economic (UN sanctions) and military coercion (the US and the UK military operation «Desert Fox»). In summer 1991, UNSCOM formed a Destruction Advisory Panel to develop technologies for the destruction of chemical weapons, toxic substances and their precursors. Their destruction was carried out in the period October 1992 to May 1994 on the territory of the Muthanna State Establishment. Sarin, cyclosarin, tabun and their precursors were destroyed by hydrolysis in aqueous alkaline solution using a repurposed production facility. Thus 76 tons of sarin and sarin/cyclosarin mixture, as well as 40 tons of tabun were destroyed. For the sulfur mustard, the high-temperature direct burning method was used at the special factory, established under the project of the Destruction Advisory Panel. Thus were destroyed around 400 tons of liquid sulfur mustard. Chemical munitions and containers, after the extraction of poisonous agents, were destroyed using a specially developed technique of explosive ventilation and burning. 30 chemical warheads for Al-Hussein ballistic missiles, 12,8 thousand 155-mm mustard shells, 40,5 thousand 122 mm rockets for MLRS, filled with sarin/cyclosarin, were destroyed. In general, UNSCOM managed to solve the problem of chemical disarmament of Iraq. The article describes in details the Iraq’s chemical weapons destruction technologies


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