Postoperative Pain Control with a New Transdermal Fentanyl Delivery System

1995 ◽  
Vol 83 (3) ◽  
pp. 470-477. ◽  
Author(s):  
Rafael Miguel ◽  
Joel M. Kreitzer ◽  
Douglas Reinhart ◽  
Peter S. Sebel ◽  
Julius Bowie ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Delivery System ◽  
Pain Control ◽  
Fentanyl Patch ◽  
Postoperative Pain Control ◽  
Transdermal Fentanyl ◽  
Placebo Patch ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background A new transdermal delivery system for fentanyl is available in two strengths: 70-80 and 90-100 micrograms.kg-1.h-1 (40- and 60-cm2 patches, respectively). Their short onset and 24-h drug delivery make them attractive for postoperative pain control. Methods Both doses of the new transdermal fentanyl patches were evaluated for the relief of postoperative pain in 143 patients after gynecologic exploratory laparotomy. The study was conducted at four centers using a prospective, randomized, placebo-controlled, double-blind format. Patients were randomly assigned to one of three study groups: group 1 patients received two placebo patches: group 2 patients received a 40-cm2 fentanyl patch and a 60-cm2 placebo patch; and group 3 patients received a 60-cm2 fentanyl patch and a 40-cm2 placebo patch. Patient-controlled morphine use and pain, sedation, and comfort scores were assessed postoperatively every 4 h for 36 h after patch placement. Results Patients' assessment of their analgesia was significantly (P < or = 0.05) better in group 2 at 16 and 24 h and in group 3 at 8, 12, 16, 20, and 24 h postoperatively, compared with the patients in group 1. Patients in groups 2 and 3 required less supplemental morphine to maintain satisfactory analgesia than did the patients in group 1. Patients in groups 2 and 3 had greater incidences of pruritus, erythema, and respiratory depression than did those receiving placebo. Conclusions Concern exists regarding the side effects of this this new transdermal fentanyl patch. Therefore, this new patch will need further research before it can be recommended as an adjunct in controlling postoperative pain.

UTILITY OF A NEW TRANSDERMAL FENTANYL DELIVERY SYSTEM FOR POSTOPERATIVE PAIN CONTROL

1992 ◽  
Vol 77 (Supplement) ◽  
pp. A886 ◽  
Author(s):  
R. Miguel ◽  
J. Kreitzer ◽  
D. Reinhart ◽  
J. Eisenkraft ◽  
P. Sebel ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Delivery System ◽  
Pain Control ◽  
Postoperative Pain Control ◽  
Transdermal Fentanyl

scholarly journals Is the transdermal fentanyl patch an efficient way to achieve acute postoperative pain control?

Medicine ◽  
2018 ◽  
Vol 97 (51) ◽  
pp. e13768 ◽  
Author(s):  
Ji Su Jang ◽  
Sung Mi Hwang ◽  
Youngsuk Kwon ◽  
Hyunjin Tark ◽  
Young Joon Kim ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Control ◽  
Fentanyl Patch ◽  
Postoperative Pain Control ◽  
Acute Postoperative Pain ◽  
Transdermal Fentanyl ◽  
Transdermal Fentanyl Patch

Postoperative Pain Control with a New Transdermal Fentanyl Delivery System

1996 ◽  
Vol 40 (6) ◽  
pp. 382
Author(s):  
RAFAEL MIGUEL ◽  
JOEL M. KREITZER ◽  
DOUGLAS REINHART ◽  
PETER S. SEBEL ◽  
JULIUS BOWIE ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Delivery System ◽  
Pain Control ◽  
Postoperative Pain Control ◽  
Transdermal Fentanyl

A study of the use of a transdermal fentanyl patch in cats

1996 ◽  
Vol 32 (1) ◽  
pp. 19-24 ◽  
Author(s):  
M Scherk-Nixon
Keyword(s):  
Pain Control ◽  
Cost Effective ◽  
Therapeutic System ◽  
Fentanyl Patch ◽  
Postoperative Pain Control ◽  
Transdermal Fentanyl ◽  
Fentanyl Citrate ◽  
Blood Samples ◽  
Continuous Delivery ◽  
Transdermal Fentanyl Patch

A transdermal therapeutic system (TTS) has been developed for the continuous delivery of fentanyl citrate to provide ongoing analgesia in human patients with chronic pain. Several researchers believe that fentanyl transdermal patches have a place in postoperative pain control. The purpose of this study was to determine whether transdermal technology is an effective way of administering fentanyl to feline patients. Fentanyl patches were applied to the skin of six cats, and blood samples for fentanyl analysis were collected over 104 hours. This study establishes that the transdermal patch technology is an effective, long-lasting, cost-effective, noninvasive, and well-tolerated mode of deliverying fentanyl to cats.

scholarly journals A Comparative Study of 0.25% Levobupivacaine, 0.25% Ropivacaine, and 0.25% Bupivacaine in Paediatric Single Shot Caudal Block

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Jagdeep Sharma ◽  
Ruchi Gupta ◽  
Anita Kumari ◽  
Lakshmi Mahajan ◽  
Jasveer Singh
Keyword(s):  
Postoperative Pain ◽  
Demographic Data ◽  
Single Shot ◽  
Haemodynamic Parameter ◽  
Paediatric Patients ◽  
Parametric Data ◽  
Intergroup Comparison ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim. There are limited data comparing levobupivacaine, ropivacaine, and bupivacaine in paediatric patients. So, this study was performed to evaluate the caudal effectiveness of all the three drugs in paediatric patients undergoing infraumbilical surgeries and associated complications with these drugs. Material and Methods. 90 patients of ASA grade I and II posted for elective infraumbilical surgeries were randomly divided into three groups of 30 each. A standardized anaesthetic protocol was used. Patients received 0.25% levobupivacaine in group 1, 0.25% ropivacaine in group 2, and 0.25% bupivacaine in group 3. The effectiveness of block was assessed using caudal effectiveness score. Postoperative pain relief was assessed with modified Hannallah pain score. Haemodynamic parameter monitoring was done. The duration of analgesia and associated complications were studied. Statistical analysis was done using the chi-square test for nonparametric data. Parametric data were analysed using ANOVA for intergroup comparison and Tukey’s HSD for intragroup comparison. Results. Demographic data were comparable. Haemodynamic parameters remained within normal range. Mean caudal effectiveness score in all the three groups was statistically insignificant (p>0.05). The duration of analgesia provided by bupivacaine (145.31 ± 26.17 min) was longer than levobupivacaine (126.15 ± 15.15 min) and ropivacaine (114.68 ± 11.32 min) (p<0.01). Mean postoperative pain scores were lower in group 3 as compared to group 1 and group 2. Conclusion. We conclude that levobupivacaine and ropivacaine provide similar intraoperative quality with minimal haemodynamic variability and shorter duration of postoperative analgesia without any significant complications when compared with racemic bupivacaine. This trial is registered with CTRI/2018/03/012402.

scholarly journals Comparison of post-tonsillectomy pain by using tramadol, lignocaine with adrenaline and normal saline swab in tonsillar fossae.

2021 ◽  
Vol 28 (08) ◽  
pp. 1206-1210
Author(s):  
Tahir Hussain Khan ◽  
◽  
Ashfaq Hussain Rana ◽  
Mohammad Afzal ◽  
Farooq Bhutta ◽  
...  
Keyword(s):  
Pain Score ◽  
Normal Saline ◽  
Pain Control ◽  
Sampling Technique ◽  
Saline Group ◽  
Post Operative Pain ◽  
Control Versus ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objective: To compare the effects of pain by using tramadol, lignocaine 2% with adrenaline and normal saline (placebo) after tonsillectomy. Study Design: Randomized Controls Trial. Setting: Department of ENT, Social Security Landhi Hospital Karachi. Period: March 2019 to October 2019. Sampling Technique: Non probability. Material & Methods: One hundred and twenty (120) patients with ASA-I status, age between 12 to 22 years were included randomly for this study. Divided the patients into three groups, group-1(L), group-2(T) and group-3(S) and forty (40) patients were in each group. In group-1(L), Lignocaine 2% with adrenaline used. In group-2 (T), Tramadol used and in group-3 (S), normal saline swab (placebo) used in tonsillar fossae at the end of tonsillectomies. Pain assessment done after 30 minutes in PACU and every one hourly for 6 hours post operatively in ward. If recorded VAS for pain was more than 5 analgesic injection given in ward for pain control. Result: The result of our research revealed that there were no significant differences in the mean ages of the patients, weight of patients, sex distribution and the duration of surgeries among the all three groups. Post-operative pain score were significantly higher in (S) group than in the other two groups (p<0.05). In Group-1(L) and Group-2 (T) pain score had non-significant (p>0.05). Duration of first analgesic demand was longer in Group-L and in Group-T versus normal saline (Group-S), it was 134 + 18 minutes in Group-L and in Group -T, it was 135 + 15 minutes while in Group-S, it was 34 + 11 minutes and p < 0.01 significant. Conclusion: Uses of lignocaine 2% with adrenaline swab and Tramadol swab are better choice in tonsillar fossae at the end of tonsillectomies for post-operative pain control versus normal saline (placebo) swab.

Preemptive analgesia in hip arthroscopy: intra-articular bupivacaine does not improve pain control after preoperative peri-acetabular blockade

2020 ◽  
pp. 112070002095024
Author(s):  
Efi Kazum ◽  
Ehud Rath ◽  
Amir Shlaifer ◽  
Zachary T Sharfman ◽  
Hal D Martin ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Hip Arthroscopy ◽  
Pain Control ◽  
Recovery Room ◽  
Postoperative Pain Management ◽  
Control Group ◽  
Analgesic Consumption ◽  
Pain Scores ◽  
Group 2 ◽  
Group 1

Introduction: Literature addressing postoperative pain management after hip arthroscopy is relatively scarce. This study aimed to assess if there was added analgesic benefit associated with postoperative intra-articular bupivacaine blockade for patients who received preoperative peri-acetabular blockade for hip arthroscopy procedures. Methods: 52 patients were included in this comparative cohort study. Group 1 consisted of 20 patients who received preoperative peri-acetabular blockade and postoperative intra-articular blockade. The control group (Group 2), consisted of 32 patients who received only preoperative peri-acetabular blockade. Postoperative pain was recorded via visual analogue scale (VAS) pain scores, analgesic consumption, and pain diaries for 2 weeks postoperatively. Results: Postoperative VAS pain scores were significantly lower in the experimental group at the 30-minute recovery room assessment (VAS scores Group 1: 1.1; Group 2: 3.00, p = 0.034). Other than the 30-minute recovery room assessment, VAS pain scores, narcotic medication consumption, and non-narcotic analgesic consumption did not differ between the 2 groups at any time point in the study period. Conclusions: This study did not demonstrate significant clinical benefit for patients who receive postoperative intra-articular blockade in addition to preoperative peri-acetabular blockade with bupivacaine 0.5%. We recommend the use of preoperative peri-acetabular bupivacaine blockade without intra-articular blockade postoperatively for pain control in the setting of hip arthroscopy surgery.

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