EFFECT OF SMOKING ON ARSENIC METHYLATION IN A POPULATION WITH HIGH ARSENIC EXPOSURE

Epidemiology ◽  
1996 ◽  
Vol 7 (Supplement) ◽  
pp. S85
Author(s):  
C Hopenhayn-Rich ◽  
M L Biggs ◽  
L E Moore ◽  
D A Kalman ◽  
A H Smith
2015 ◽  
Vol 123 (2) ◽  
pp. 186-192 ◽  
Author(s):  
Jessica E. Laine ◽  
Kathryn A. Bailey ◽  
Marisela Rubio-Andrade ◽  
Andrew F. Olshan ◽  
Lisa Smeester ◽  
...  

2021 ◽  
Author(s):  
Arun Kumar ◽  
Rishav Kumar ◽  
Md. Samiur Rahman ◽  
Mohammad Ali ◽  
Ranjit Kumar ◽  
...  

Abstract Arsenic poisoning through groundwater is the world's greatest normal groundwater catastrophe which got an immense effect on worldwide general wellbeing. India is confronting the outcomes of arsenic poisoning in the zone of Ganga Brahmaputra alluvial plains. In Bihar out of 38 districts, 18 districts are exceptionally influenced with groundwater arsenic defilement. In the present study, we have assessed the current situation of arsenic exposure in Sabalpur village of Saran district of Bihar after reporting of breast, renal, skin and thyroid cancer cases from this village along with typical symptoms of arsenicosis. Such cancer patients were identified at our institute and were taken for the study. The present investigation deals with the quantification of arsenic in groundwater, hair and nail samples as well as the survey of entire village to know the overall health status of the village people. Altogether, 128 groundwater samples through handpumps, 128 human hair and nail samples respectively were collected from over 520 households. Using the Graphite Furnace Atomic Absorption Spectrophotometer (GF-AAS), all the samples were analysed. The investigation resulted that the 61% of the analysed samples particularly the groundwater had the arsenic levels more than the permissible limit of WHO (>10µg/L) with 244.20µg/L as the greatest arsenic contamination in one of the groundwater sample. The exposure effect of hair sample was worst as 88% of all the collected samples were having high arsenic levels more than the permissible limit (>0.2mg/Kg). In case of nails samples, 92% of the samples were having high arsenic concentration more than the permissible limit (>0.5mg/Kg). The health survey study uncovered the exceptionally chronic weakness status of the village populace as individuals were experiencing the issues like asthma, anaemia, hepatomegaly, diabetes, cardiac problem, skin fungal infections, breathlessness, mental disability, etc. Few cancer cases of renal, skin, breast and cervix were also found among the population of this village. The percentage of cancer cases in this village was 0.94% that is low but it would be an aggravated situation in the near future if people will continue drinking arsenic contaminated water. Therefore, a mitigation intervention was done in March 2020 by installing an arsenic filter plant. The health situation in the present scenario is hope to restore in the village in the coming years. However, motivation and awareness among the village population is still required.


Epidemiology ◽  
1998 ◽  
Vol 9 (Supplement) ◽  
pp. S152
Author(s):  
C Hopenhavn-Rich ◽  
I Hertz-Picciotto ◽  
Johnson KD

2013 ◽  
Vol 121 (7) ◽  
pp. 832-838 ◽  
Author(s):  
Yu Chen ◽  
Fen Wu ◽  
Mengling Liu ◽  
Faruque Parvez ◽  
Vesna Slavkovich ◽  
...  

Epidemiology ◽  
1995 ◽  
Vol 6 (2) ◽  
pp. S54
Author(s):  
A H Smith ◽  
L E Moore ◽  
C M Hopenhayn-Rich ◽  
M L Biggs ◽  
D A Kalman ◽  
...  

2022 ◽  
Author(s):  
Arun Kumar ◽  
Mohammad Ali ◽  
Vivek Raj ◽  
Arti Kumari ◽  
Mahesh Rachhamala ◽  
...  

Abstract BackgroundIn recent times Gallbladder cancer (GBC) incidences increased many folds in India. Majority of GBC cases are being reported from arsenic hotspots identified in Bihar. MethodsIn this prospective study volunteers were selected who underwent surgery in our cancer institute. There were 11 control benign gallbladder cases and 28 confirmed gallbladder cancer cases. Their biological samples such as blood, gallbladder tissue, gallbladder stone, bile and hair samples were collected for arsenic estimation. Moreover, n=512 gallbladder cancer patients blood samples were evaluated for the presence of arsenic to understand exposure level in the population. ResultsA significantly high arsenic concentration (p<0.05) was detected in the blood samples, gallbladder tissue, gallstones, bile and hair samples in comparison to the control group. Moreover, n=512 blood samples of GBC patients had significantly very high arsenic concentration. ConclusionsThe study shows very high arsenic concentration observed in the blood, gallbladder tissue, gallbladder stone, bile and hair samples in GBC cases in comparison to the benign control cases indicates the correlation between chronic arsenic exposure and gallbladder cancer incidences in eastern Indo-Gangetic plains region. The study also makes an attempt to establish the likely correlation/association between arsenic exposure and gallbladder cancer disease.


Dose-Response ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 155932582095782
Author(s):  
Paolo Boffetta ◽  
Carlotta Zunarelli ◽  
Claire Borron

Background: Exposure to high arsenic concentrations in drinking water has been associated with skin lesions. Our goal was to conduct a systematic review of studies on skin lesions and arsenic exposure, with emphasis on results at low level of exposure. Methods: We conducted a systematic review of studies reporting estimates of either prevalence or risk of skin lesions associated with exposure to more than 2 levels of arsenic in drinking water. We reviewed and abstracted the relevant results, with the aim of conducting a dose-response meta-analysis. Results: Nine studies of skin lesions were reviewed. Strong heterogeneity in the results did not meet the criteria for performing a meta-analysis. The relative risks for an increase of 10 μg/L arsenic in drinking water ranged from 1.002 to 1.140 (p-value of heterogeneity < 0.0001). Protection from bias and confounding was inadequate in most studies. Conclusion: Current studies are inadequate to conduct meta-analysis on dose-response relationship between exposure to arsenic in drinking water and skin lesions. Studies with complete exposure histories indicate skin lesions are associated with arsenic exposure in excess of 50 µg/L or higher.


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