Differential Diagnosis Between Adenoid Cystic Carcinoma and Pleomorphic Adenoma of the Minor Salivary Glands of Palate

Adenoid cystic carcinoma is a relatively uncommon tumour of salivary, glands and is characterised by a prolonged clinical course and a fatal outcome. It was first described as `cylindroma' by Billroth in 1859. Half of these tumors occur in glandular tissues other than the major salivary glands; principally in the hard palate, but they can also arise in the tongue and minor salivary glands. Unusual locations include the external auditory canal, nasopharynx, lacrimal glands, breast, vulva, esophagus, cervix and Cowper glands. The long natural history of this tumor and its tendency for local recurrence are well known. JMS 2012;15(1):76-77.

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Clinical Utility of MYB Rearrangement Detection and P63/P40 Immunophenotyping in the Diagnosis of Adenoid Cystic Carcinoma of Minor Salivary Glands: A Pilot Study

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2015.05.057 ◽

2015 ◽

Vol 120 (3) ◽

pp. e154

Author(s):

S. WETZEL ◽

P. ARGYRIS ◽

R. WEHRS ◽

P. GREIPP ◽

D. KNUTSON ◽

...

Keyword(s):

Pilot Study ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Clinical Utility ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Adenoid cystic carcinoma of the tongue

The Journal of Laryngology & Otology ◽

10.1258/0022215001905922 ◽

2000 ◽

Vol 114 (6) ◽

pp. 477-480 ◽

Cited By ~ 5

Author(s):

Emre Üstündaĝ ◽

Mete Iseri ◽

O¨mer Aydin ◽

Hülya Dal ◽

Ahmet Almaç ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Neck Dissection ◽

Pleomorphic Adenoma ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Wide Resection ◽

Selective Neck Dissection ◽

Fine Needle ◽

Adenoid Cystic

Malignant tumours of the salivary glands in children are extremely rare. We present here a 12-year-old girl initially diagnosed as pleomorphic adenoma on fine needle aspiration biopsy, and adenoid cystic carcinoma (ACC) after the lesion was excised and examined by histopathology. A wide resection of the lesion and bilateral supraomyohyoid neck dissection was performed. To our knowledge this is one of the youngest patients with ACC of the minor salivary glands. Due to its benign histological appearance, the biological agressiveness of ACC is usually underestimated. Although fine needle aspiration cytology (FNAC) is very valuable in diagnosis, cytological variations of pleomorphic adenoma must be considered. ACC of the tongue in a young age group should be treated with wide resection and selective neck dissection if the tumour is localized in places where the risk of metastasis is increased and if there is a clinically palpable lymph node. In such cases the clinician should not avoid radical operations even in a young patient.

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Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours

The International Journal of Biological Markers ◽

10.5301/jbm.2012.10373 ◽

2012 ◽

Vol 27 (4) ◽

pp. 381-388 ◽

Cited By ~ 5

Author(s):

Mark R. Darling ◽

Nelly N. Hashem ◽

Irene Zhang ◽

Mohamed Mohamed ◽

Kevin Fung ◽

...

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Salivary Gland Tumour ◽

Immunoperoxidase Staining ◽

Aberrant Expression ◽

Adenoid Cystic ◽

Gland Tumour

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

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Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population

Shiraz E-Medical Journal ◽

10.5812/semj.107675 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Nafise Shamloo ◽

Alireza Ghanadan ◽

Fahimeh Sadat Hashemian ◽

Maedeh Ghorbanpour

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Malignant Tumors ◽

The Body ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Cross Sectional ◽

Adenoid Cystic

Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pleomorphic adenoma in 794 cases (67.3%) and adenoid cystic carcinoma in 109 cases (9.2%) were the most common tumors, respectively. Salivary gland tumors were more common in males, and the participants’ mean age was 42.86 ± 16.5 years. The most common site was parotid and minor salivary glands, with 937 (79.4%) and 137 (12%) cases, respectively. Conclusions: In this study, the most common benign tumor was pleomorphic adenoma in the parotid gland, and the most common malignant tumor was adenoid cystic carcinoma in the major salivary glands. Furthermore, benign tumors were more frequent than malignant tumors.

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ADENOID CYSTIC CARCINOMA OF MINOR SALIVARY GLANDS: CASE REPORT

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2019.06.333 ◽

2020 ◽

Vol 129 (1) ◽

pp. e82

Author(s):

CAMILA OLIVEIRA SANTOS ◽

ALYNE AMORIM DE ARAÚJO ◽

RODRIGO RESENDE ◽

VANIA DO CARMO ◽

LUISA AGUIRRE BUEXM ◽

...

Keyword(s):

Case Report ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Adenoid cystic carcinoma of major and minor salivary glands

The American Journal of Surgery ◽

10.1016/0002-9610(71)90440-5 ◽

1971 ◽

Vol 122 (6) ◽

pp. 756-762 ◽

Cited By ~ 64

Author(s):

Stuart W. Leafstedt ◽

John F. Gaeta ◽

Kumao Sako ◽

Frank C. Marchetta ◽

Donald P. Shedd

Keyword(s):

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Epidemiology and treatment of adenoid cystic carcinoma of the minor salivary glands: A meta-analytic study

Medicina Oral Patología Oral y Cirugia Bucal ◽

10.4317/medoral.17200 ◽

2011 ◽

pp. e884-e889 ◽

Cited By ~ 15

Author(s):

N. Martinez-Rodriguez ◽

I. Leco-Berrocal ◽

L. Rubio-Alonso ◽

O. Arias-Irimia ◽

JM. Martinez-Gonzalez

Keyword(s):

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Analytic Study ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Adenoid cystic carcinoma of intraoral minor salivary glands

Oral Oncology ◽

10.1016/j.oraloncology.2008.01.005 ◽

2008 ◽

Vol 44 (11) ◽

pp. 1026-1031 ◽

Cited By ~ 37

Author(s):

B. Bianchi ◽

C. Copelli ◽

R. Cocchi ◽

S. Ferrari ◽

N. Pederneschi ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20203195 ◽

2020 ◽

Vol 6 (8) ◽

pp. 1460

Author(s):

Prakash Mylanahalli Doddrangaiah ◽

Bharath Kanna Karunakaran ◽

Roopa S. Mallali ◽

Afshan Fathima

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Hard Palate ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

Minor Salivary Gland Tumour ◽

Gland Tumour

Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.Methods: This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet. Results: We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).Conclusions: ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.

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