Background: Cancer treatment can have a significant impact on an individual's quality of life. In particular, body image and sexuality can be compromised. There is increasing evidence that conversations about these specific consequences are not happening often between cancer patients and health care providers, especially in busy clinical settings. Aim: This work will contrast the perspectives of nurses caring for cancer patients in Canada and in Africa regarding having conversations about the topic of sexuality with patients and family members after a cancer diagnosis. Methods: Data were collected through interviews with nurses (n=34) in Canada and through small group discussions with nurses (n=25) in Africa. Data were reviewed using a descriptive qualitative approach, identifying significant themes. Results: Overall, participants acknowledged treatment can have an impact on a patient's sexuality. If conversations occurred, it was during consent processes before treatment began or when a patient raised a question about a specific side effect. These conversations rarely covered more than the physical changes and did not focus on the impact of changes on emotional and personal relationships or intimacy. Most providers waited for patients to raise any concerns or questions. Most participants expressed their own personal discomfort and lack of training for holding these types of conversations. They perceived the conversations as difficult for themselves as well as for patients. The topic of sexuality was often described as a taboo topic, especially in Africa, and one that was influenced strongly by cultural perspectives. Having time and privacy to hold the discussions were also seen as barriers. Conclusion: The findings support the need to clarify role responsibilities for cancer nurses, as well as other members of the cancer care team, about patient care regarding the area of sexuality, and the provision of education.