scholarly journals Neonatal vincristine administration modulates intrinsic neuronal excitability in the rat dorsal root ganglion and spinal dorsal horn during adolescence

Pain ◽  
2019 ◽  
Vol 160 (3) ◽  
pp. 645-657 ◽  
Author(s):  
Katie A. Schappacher ◽  
Wenrui Xie ◽  
Jun-Ming Zhang ◽  
Mark L. Baccei
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Dorsal Root ◽  
Spinal Dorsal Horn ◽  
Neuronal Excitability ◽  
Spinal Dorsal

RETRACTED: Effects of electro-acupuncture on NT-4 expression in spinal dorsal root ganglion and associated segments of the spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomy

2009 ◽  
Vol 450 (2) ◽  
pp. 158-162 ◽  
Author(s):  
Fen Liu ◽  
Wei-Wei Sun ◽  
Ying Wang ◽  
Li-Qun Hu ◽  
Ping Dai ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Dorsal Root ◽  
Spinal Dorsal Horn ◽  
Spinal Dorsal

scholarly journals L-bupivacaine Inhibition of Nociceptive Transmission in Rat Peripheral and Dorsal Horn Neurons

2020 ◽  
Vol 134 (1) ◽  
pp. 88-102
Author(s):  
Daisuke Uta ◽  
Kohei Koga ◽  
Hidemasa Furue ◽  
Keiji Imoto ◽  
Megumu Yoshimura
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Dorsal Root ◽  
Spinal Dorsal Horn ◽  
Dorsal Root Ganglion Neurons ◽  
Evoked Responses ◽  
Half Maximum ◽  
Sodium Currents ◽  
Spinal Dorsal ◽  
Ganglion Neurons

Background Although the widely used single L-enantiomers of local anesthetics have less toxic effects on the cardiovascular and central nervous systems, the mechanisms mediating their antinociceptive actions are not well understood. The authors hypothesized that significant differences in the ion channel blocking abilities of the enantiomers of bupivacaine would be identified. Methods The authors performed electrophysiologic analysis on rat dorsal root ganglion neurons in vitro and on spinal transmissions in vivo. Results In the dorsal root ganglion, these anesthetics decreased the amplitudes of action potentials. The half-maximum inhibitory concentrations of D-enantiomer D-bupivacaine were almost equal for Aβ (29.5 μM), Aδ (29.7μM), and C (29.8 μM) neurons. However, the half-maximum inhibitory concentrations of L-bupivacaine was lower for Aδ (19.35 μM) and C (19.5 μM) neurons than for A β (79.4 μM) neurons. Moreover, D-bupivacaine almost equally inhibited tetrodotoxin-resistant (mean ± SD: 15.8 ± 10.9% of the control, n = 14, P < 0.001) and tetrodotoxin-sensitive (15.4 ± 15.6% of the control, n = 11, P = 0.004) sodium currents. In contrast, L-bupivacaine suppressed tetrodotoxin-resistant sodium currents (26.1 ± 19.5% of the control, n = 18, P < 0.001) but not tetrodotoxin-sensitive sodium currents (74.5 ± 18.2% of the control, n = 11, P = 0.477). In the spinal dorsal horn, L-bupivacaine decreased the area of pinch-evoked excitatory postsynaptic currents (39.4 ± 11.3% of the control, n = 7, P < 0.001) but not touch-evoked responses (84.2 ± 14.5% of the control, n = 6, P = 0.826). In contrast, D-bupivacaine equally decreased pinch- and touch-evoked responses (38.8 ± 9.5% of the control, n = 6, P = 0.001, 42.9 ± 11.8% of the control, n = 6, P = 0.013, respectively). Conclusions These results suggest that the L-enantiomer of bupivacaine (L-bupivacaine) effectively inhibits noxious transmission to the spinal dorsal horn by blocking action potential conduction through C and Aδ afferent fibers. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New

Pregabalin Alters Nociceptive Behavior and Expression Level of P2X3 Receptor in the Spinal Dorsal Horn in a Rat Model Induced by Chronic Compression of the Dorsal Root Ganglion

2013 ◽  
Vol 296 (12) ◽  
pp. 1907-1912 ◽  
Author(s):  
Jianfeng Yu ◽  
Peng Fu ◽  
Yan Zhang ◽  
Shuzhen Liu ◽  
Donghong Cui
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Rat Model ◽  
Dorsal Root ◽  
Spinal Dorsal Horn ◽  
Expression Level ◽  
P2x3 Receptor ◽  
Nociceptive Behavior ◽  
Spinal Dorsal

scholarly journals Convergence of peptidergic and non‐peptidergic protein markers in the human dorsal root ganglion and spinal dorsal horn

2021 ◽  
Author(s):  
Stephanie I. Shiers ◽  
Ishwarya Sankaranarayanan ◽  
Vivek Jeevakumar ◽  
Anna Cervantes ◽  
Jeffrey C. Reese ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Horn ◽  
Dorsal Root ◽  
Spinal Dorsal Horn ◽  
Protein Markers ◽  
Spinal Dorsal
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