EFFECT OF AN ENDOTHELIN ANTAGONIST ON VASCULAR RESPONSIVENESS TO VASOPRESSIN AND ANGIOTENSIN II IN DEOXYCORTICOSTERONE ACETATE-SALT HYPERTENSIVE RATS

2000 ◽  
Vol 18 ◽  
pp. S131
Author(s):  
J. R. McNeill ◽  
M. Yu ◽  
V. Gopalakrishnan
Keyword(s):  
Angiotensin Ii ◽  
Hypertensive Rats ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Vascular Responsiveness ◽  
Endothelin Antagonist

scholarly journals Role of angiotensin II in renal injury of deoxycorticosterone acetate-salt hypertensive rats.

Hypertension ◽  
1994 ◽  
Vol 24 (2) ◽  
pp. 195-204 ◽  
Author(s):  
S Kim ◽  
K Ohta ◽  
A Hamaguchi ◽  
T Omura ◽  
T Yukimura ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Renal Injury ◽  
Hypertensive Rats ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt

Cerebral vascular responsiveness in deoxycorticosterone acetate-salt hypertensive rats

1987 ◽  
Vol 252 (1) ◽  
pp. H198-H203 ◽  
Author(s):  
E. E. Soltis ◽  
D. F. Bohr
Keyword(s):  
Basilar Artery ◽  
Contractile Response ◽  
Hypertensive Rats ◽  
Deoxycorticosterone Acetate ◽  
Response Characteristics ◽  
Acetate Salt ◽  
Vascular Responsiveness ◽  
Intracellular Ca ◽  
Relaxation Responses ◽  
Cerebral Vascular

Alterations in cerebral vascular responsiveness were investigated in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Initial studies on the passive-force response characteristics of strips of basilar artery revealed no difference between control and DOCA-salt rats. No difference in acetylcholine-induced relaxation was seen between the two groups. The contractile response to KCl was similar in control and DOCA-salt rats. An increase in both threshold and midrange sensitivities to serotonin (5-HT) was seen in basilar artery from DOCA-salt rats. However, extracellular Ca sensitivity in the presence of 10(-6) M 5-HT was not altered. Intracellular Ca release (phasic contraction in response to 10(-6) M 5-HT) was similar in control and DOCA-salt rats. Relaxation in response to Ca (membrane stabilization) was also not different. Whereas sodium nitroprusside (SNP)-induced relaxation was not altered in basilar artery from DOCA-salt rats, a significant decrease in isoproterenol (ISO)-induced relaxation was observed. Relaxation following washout of maximal contractions to KCl and 5-HT was similar in the two groups. These results demonstrate specific alterations in cerebral vascular responsiveness of DOCA-salt rats. Whereas KCl contractile and SNP relaxation responses were not affected, responses to 5-HT and ISO were significantly altered. These changes do not appear to be related to alterations in the endothelium or in the Ca responsiveness of the vascular smooth muscle.

Role of angiotensin II in cerebrovascular and renal damage in deoxycorticosterone acetate-salt hypertensive rats

1995 ◽  
Vol 13 (1) ◽  
pp. 113???122 ◽  
Author(s):  
Takeo Wada ◽  
Rei Kanagawa ◽  
Yoshimasa Ishimura ◽  
Yoshiyuki Inada ◽  
Kohei Nishikawa
Keyword(s):  
Angiotensin Ii ◽  
Renal Damage ◽  
Hypertensive Rats ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt

scholarly journals Effects of Rosiglitazone on Heat Shock Protein and the Endothelin System in Deoxycorticosterone Acetate-Salt Hypertensive Rats

2008 ◽  
Vol 6 (1) ◽  
pp. 1 ◽  
Author(s):  
Eun Hui Bae ◽  
In Jin Kim ◽  
Jeong Woo Park ◽  
Seong Kwon Ma ◽  
Ki Chul Choi ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Hypertensive Rats ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Endothelin System

Renal Damages in Deoxycorticosterone Acetate–Salt Hypertensive Rats: Assessment with Diffusion Tensor Imaging and T2-mapping

2019 ◽  
Vol 22 (1) ◽  
pp. 94-104 ◽  
Author(s):  
Sheung-Fat Ko ◽  
Hon-Kan Yip ◽  
Yen-Yi Zhen ◽  
Chi-Chih Hung ◽  
Chen-Chang Lee ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
T2 Mapping ◽  
Hypertensive Rats ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt
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