Galactose inhibition of neonatal neutrophil function

Resveratrol, is a polyphenol that can be extracted from grapes and red wine, possess potential anti-inflammatory effects, which would result in the reduction of cytokine production, the alteration of the expression of adhesion molecule molecules, and the inhibition of neutrophil function. Resveratrol might also act as an antioxidant, anti-aging, and control of cell cycle and apoptosis. Resveratrol has been shown to have protective effects for patients in shock-like states. Such protective phenomenon is reported to be implicated in a variety of intracellular signaling pathways including the regulation of the mitogen-activated protein kinases (MAPK)/ hemeoxygenase-1 (HO-1) pathway, activates estrogen receptor (ER), and the mediation of pro-inflammatory cytokines, reactive oxygen species (ROS) formation and reactive. Moreover, through anti-inflammatory effects and antioxidant properties, the resveratrol is believed to maintain organ function following trauma-hemorrhage.Key words: resveratrol, anti-inflammatory, trauma-hemorrhage.

Download Full-text

Association of metabolic markers with neutrophil function in healthy postpartum dairy cows

Veterinary Immunology and Immunopathology ◽

10.1016/j.vetimm.2020.110182 ◽

2021 ◽

Vol 232 ◽

pp. 110182

Author(s):

O. Bogado Pascottini ◽

T.C. Bruinjé ◽

R. Couto Serrenho ◽

B. Mion ◽

S.J. LeBlanc

Keyword(s):

Dairy Cows ◽

Neutrophil Function ◽

Metabolic Markers

Download Full-text

Encapsulated NOLA™ Fit 5500 Lactase—An Economically Beneficial Way to Obtain Lactose-Free Milk at Low Temperature

Catalysts ◽

10.3390/catal11050527 ◽

2021 ◽

Vol 11 (5) ◽

pp. 527

Author(s):

Katarzyna Czyzewska ◽

Anna Trusek

Keyword(s):

Low Temperature ◽

Storage Temperature ◽

Competitive Inhibition ◽

Caloric Content ◽

Substrate Diffusion ◽

Galactose Inhibition ◽

The Subject ◽

And Storage ◽

Food Processes ◽

Hydrolysis Of

The current requirements of industrial biocatalysis are related to economically beneficial and environmentally friendly processes. Such a strategy engages low-temperature reactions. The presented approach is essential, especially in food processes, where temperature affects the quality and nutritional value foodstuffs. The subject of the study is the hydrolysis of lactose with the commercial lactase NOLA™ Fit 5500 (NOLA). The complete decomposition of lactose into two monosaccharides gives a sweeter product, recommended for lactose intolerant people and those controlling a product’s caloric content. The hydrolysis reaction was performed at 15 °C, which is related to milk transportation and storage temperature. The enzyme showed activity over the entire range of substrate concentrations (up to 55 g/L lactose). For reusability and easy isolation, the enzyme was encapsulated in a sodium alginate network. Its stability allows carrying out six cycles of the complete hydrolysis of lactose to monosaccharides, lasting from two to four hours. During the study, the kinetic description of native and encapsulated NOLA was conducted. As a result, the model of competitive galactose inhibition and glucose mixed influence (competitive inhibition and activation) was proposed. The capsule size does not influence the reaction rate; thus, the substrate diffusion into capsules can be omitted from the process description. The prepared 4 mm capsules are easy to separate between cycles, e.g., using sieves.

Download Full-text