Treatment of hyperhomocysteinemia with folic acid reduces oxidative stress in renal transplant recipients

2002 ◽  
Vol 73 (4) ◽  
pp. 663-665 ◽  
Author(s):  
Aboubakr Abdelfatah ◽  
Didier Ducloux ◽  
G??rard Toubin ◽  
G??rard Motte ◽  
Daniel Alber ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Mineralocorticoid Receptor Blockade Reduced Oxidative Stress in Renal Transplant Recipients: A Double-Blind, Randomized Pilot Study

2013 ◽  
Vol 37 (5) ◽  
pp. 481-490 ◽  
Author(s):  
Marcos Ojeda-Cervantes ◽  
Jonatan Barrera-Chimal ◽  
Josefina Alberú ◽  
Rosalba Pérez-Villalva ◽  
Luis Eduardo Morales-Buenrostro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pilot Study ◽  
Renal Transplant ◽  
Mineralocorticoid Receptor ◽  
Renal Transplant Recipients ◽  
Receptor Blockade ◽  
Transplant Recipients ◽  
Double Blind ◽  
Mineralocorticoid Receptor Blockade

scholarly journals SP798RELATIONS AMONG HYPERURICEMIA,INFLAMMATION, OXIDATIVE STRESS AND ARTERIAL STIFFNESS IN RENAL TRANSPLANT RECIPIENTS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii641-iii642
Author(s):  
Bahar Gurlek Demirci ◽  
Mehtap Erkmen Uyar ◽  
Zeynep Bal ◽  
Emre Tutal ◽  
Fatma NurhanOzdemir Acar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Transplant ◽  
Arterial Stiffness ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Plasma Malondialdehyde and Risk of New-Onset Diabetes after Transplantation in Renal Transplant Recipients: A Prospective Cohort Study

2019 ◽  
Vol 8 (4) ◽  
pp. 453 ◽  
Author(s):  
Manuela Yepes-Calderón ◽  
Camilo Sotomayor ◽  
António Gomes-Neto ◽  
Rijk Gans ◽  
Stefan Berger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Transplant ◽  
Cox Proportional Hazards ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Dietary Antioxidants ◽  
Onset Diabetes ◽  
Plasma Malondialdehyde ◽  
New Onset

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft ≥1 year. We included 516 RTR (51 ± 13 years-old, 57% male). Median plasma malondialdehyde (MDA) was 2.55 (IQR, 1.92–3.66) µmol/L. During a median follow-up of 5.3 (IQR, 4.6–6.0) years, 56 (11%) RTR developed NODAT. In Cox proportional-hazards regression analyses, MDA was inversely associated with NODAT, independent of immunosuppressive therapy, transplant-specific covariates, lifestyle, inflammation, and metabolism parameters (HR, 0.55; 95% CI, 0.36–0.83 per 1-SD increase; p < 0.01). Dietary antioxidants intake (e.g., vitamin E, α-lipoic acid, and linoleic acid) were effect-modifiers of the association between MDA and NODAT, with particularly strong inverse associations within the subgroup of RTR with relatively higher dietary antioxidants intake. In conclusion, plasma MDA concentration is inversely and independently associated with long-term risk of NODAT in RTR. Our findings support a potential underrecognized role of oxidative stress in post-transplantation glucose homeostasis.

Folic acid supplementation and homocyst(e)ine level in renal transplant recipients

2001 ◽  
Vol 33 (1-2) ◽  
pp. 2049-2050 ◽  
Author(s):  
B Grandtnerová ◽  
L Laca ◽  
D Gábor ◽  
E Gregová ◽  
S Korónyi
Keyword(s):  
Folic Acid ◽  
Renal Transplant ◽  
Folic Acid Supplementation ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Acid Supplementation

Homocysteine in the Plasma of Renal Transplant Recipients: Effects of Cofactors for Methionine Metabolism

1981 ◽  
Vol 61 (6) ◽  
pp. 743-749 ◽  
Author(s):  
D. E. L. Wilcken ◽  
Vatsala J. Gupta ◽  
A. K. Betts
Keyword(s):  
Folic Acid ◽  
Amino Acid ◽  
Renal Transplant ◽  
Serum Creatinine ◽  
Vitamin B12 ◽  
Normal Subjects ◽  
Serum Folate ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Erythrocyte Folate

1. Homocysteine which is formed during the metabolism of methionine is readily oxidized and is measured by the amino acid analyser as cysteine—homocysteine mixed disulphide and homocystine. We measured plasma amino acid concentrations after an overnight fast in 27 stable long-term renal transplant recipients and 25 age-and sex-matched normal subjects with particular emphasis on sulphur-containing amino acids. 2. Plasma cysteine—homocysteine mixed disulphide was increased in the patients (mean 6.0 ± sd 3.2 μmol/l; normal 3.1 ± 0.9 μmol/l, P < 0.001) and homocystine was detectable in low concentration (< 1.0 μmol/l) in 24; the elevation in cysteine—homocysteine was related to serum creatinine (r = 0.60, P < 0.002). Cystine was also increased (91.6 ± 29.3 μmol/l; normal subjects 64.0 ± 16.7 μmol/l, P < 0.001), but methionine concentrations were normal. 3. When pyridoxine, folic acid and vitamin B12, cofactors for homocysteine metabolism, were administered sequentially to 11 arbitrarily selected transplant recipients cysteine—homocysteine decreased from 7.3 ± 2.1 to 4.3 ± 0.8 μmol/l (P < 0.001) and homocystine became undetectable. the response coincided with the giving of folic acid and occurred without alteration in serum creatinine and with normal serum folate and vitamin B12 concentrations. 4. in eight patients in whom pretreatment erythrocyte folate was measured, folic acid therapy reduced cysteine—homocysteine from 9.0 ± 3.1 to 5.4 ± 1.6 μmol/l over a 4 week period (P < 0.001), the largest response being in the one patient with subnormal erythrocyte folate; values were in the low-normal or normal range in the other seven. 5. We conclude that plasma homocysteine is increased in renal transplant recipients when serum creatinine is only moderately elevated and that the homocysteine concentrations are decreased by treatment with folic acid, suggesting that both reduced homocysteine excretion and relative shortages of folic acid are responsible.

Oxidative stress and coenzyme Q10supplementation in renal transplant recipients

2004 ◽  
Vol 36 (2) ◽  
pp. 253-258 ◽  
Author(s):  
A. Długosz ◽  
J. Kuźniar ◽  
E. Sawicka ◽  
Z. Marchewka ◽  
J. Lembas-Bogaczyk ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Correlation between oxidative stress and immunosuppressive therapy in renal transplant recipients with an uneventful postoperative course and stable renal function

2006 ◽  
Vol 38 (2) ◽  
pp. 343-348 ◽  
Author(s):  
Despina N. Perrea ◽  
Konstantinos G. Moulakakis ◽  
Maria V. Poulakou ◽  
Ioannis S. Vlachos ◽  
Antonios Papachristodoulou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Renal Transplant ◽  
Immunosuppressive Therapy ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Postoperative Course ◽  
Stable Renal Function
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