IMPAIRED VARICELLA ZOSTER VIRUS SPECIFIC MEMORY T-CELL RESPONSES IN KIDNEY TRANSPLANT PATIENTS

2010 ◽  
Vol 90 ◽  
pp. 400
Author(s):  
N. M. van Besouw ◽  
G. M.G.M. Verjans ◽  
J. M. Zuijderwijk ◽  
A. L. Geel ◽  
W. Weimar
Keyword(s):  
T Cell ◽  
Varicella Zoster Virus ◽  
Kidney Transplant ◽  
T Cell Responses ◽  
Varicella Zoster ◽  
Memory T Cell ◽  
Cell Responses ◽  
Transplant Patients ◽  
Specific Memory ◽  
Kidney Transplant Patients

scholarly journals Comparison of humoral and cellular responses in kidney transplant recipients receiving BNT162b2 and ChAdOx1 SARS-CoV-2 vaccines

2021 ◽  
Author(s):  
Maria Prendecki ◽  
Tina Thomson ◽  
Candice L Clarke ◽  
Paul Martin ◽  
Sarah Gleeson ◽  
...  
Keyword(s):  
T Cell ◽  
Kidney Transplant ◽  
T Cell Responses ◽  
Cellular Responses ◽  
Control Group ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Cell Responses ◽  
Transplant Patients ◽  
Kidney Transplant Patients

Background Attenuated immune responses to mRNA SARS-CoV-2 vaccines have been reported in solid organ transplant recipients. Most studies have assessed serological responses alone, and there is limited immunological data on vector-based vaccines in this population. This study compares the immunogenicity of BNT162b2 with ChAdOx1 in kidney transplant patients, assessing both serological and cellular responses. Methods 920 patients were screened for spike protein antibodies (anti-S) following 2 doses of either BNT162b2 (n=490) or ChAdOx1 (n=430). 106 patients underwent assessment with T-cell ELISpot assays. 65 health care workers were used as a control group. Results Anti-S was detected in 569 (61.8%) patients. Seroconversion rates in infection-naïve patients who received BNT162b2 were higher compared with ChAdOx1, at 269/410 (65.6%) and 156/358 (43.6%) respectively, p<0.0001. Anti-S concentrations were higher following BNT162b, 58(7.1-722) BAU/ml, compared with ChAdOx1, 7.1(7.1-39) BAU/ml, p<0.0001. Calcineurin inhibitor monotherapy, vaccination occurring >1st year post-transplant and receiving BNT162b2 was associated with seroconversion. Only 28/106 (26.4%) of patients had detectable T-cell responses. There was no difference in detection between infection-naïve patients who received BNT162b2, 7/40 (17.5%), versus ChAdOx1, 2/39 (5.1%), p=0.15. There was also no difference in patients with prior infection who received BNT162b2, 8/11 (72.7%), compared with ChAdOx1, 11/16 (68.8%), p=0.83. Conclusions. Enhanced humoral responses were seen with BNT162b2 compared with ChAdOx1 in kidney transplant patients. T-cell responses to both vaccines were markedly attenuated. Clinical efficacy data is still required but immunogenicity data suggests weakened responses to both vaccines in transplant patients, with ChAdOx1 less immunogenic compared with BNT162b2.

Effector Antitumor and Regulatory T Cell Responses Influence the Development of Nonmelanoma Skin Cancer in Kidney Transplant Patients

2017 ◽  
Vol 101 (9) ◽  
pp. 2102-2110 ◽  
Author(s):  
Elena Crespo ◽  
Loreto Fernandez ◽  
Marc Lúcia ◽  
Edoardo Melilli ◽  
Ricardo Lauzurica ◽  
...  
Keyword(s):  
T Cell ◽  
Skin Cancer ◽  
Kidney Transplant ◽  
Regulatory T Cell ◽  
T Cell Responses ◽  
Nonmelanoma Skin Cancer ◽  
Cell Responses ◽  
Transplant Patients ◽  
Kidney Transplant Patients

scholarly journals Analysis of T Cell Responses during Active Varicella-Zoster Virus Reactivation in Human Ganglia

2013 ◽  
Vol 88 (5) ◽  
pp. 2704-2716 ◽  
Author(s):  
M. Steain ◽  
J. P. Sutherland ◽  
M. Rodriguez ◽  
A. L. Cunningham ◽  
B. Slobedman ◽  
...  
Keyword(s):  
T Cell ◽  
Varicella Zoster Virus ◽  
T Cell Responses ◽  
Virus Reactivation ◽  
Varicella Zoster ◽  
Cell Responses

scholarly journals IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Lyssia Belarif ◽  
Caroline Mary ◽  
Lola Jacquemont ◽  
Hoa Le Mai ◽  
Richard Danger ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Inflammation ◽  
T Cell Responses ◽  
Receptor Blockade ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory

scholarly journals Norovirus-Specific Memory T Cell Responses in Adult Human Donors

2016 ◽  
Vol 7 ◽  
Author(s):  
Maria Malm ◽  
Kirsi Tamminen ◽  
Timo Vesikari ◽  
Vesna Blazevic
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Memory T Cell ◽  
Cell Responses ◽  
Adult Human ◽  
Specific Memory

scholarly journals Antibody Avidity in Humoral Immune Responses in Bangladeshi Children and Adults following Administration of an Oral Killed Cholera Vaccine

2013 ◽  
Vol 20 (10) ◽  
pp. 1541-1548 ◽  
Author(s):  
Mohammad Murshid Alam ◽  
Daniel T. Leung ◽  
Marjahan Akhtar ◽  
Mohammad Nazim ◽  
Sarmin Akter ◽  
...  
Keyword(s):  
T Cell ◽  
B Cell ◽  
T Cell Responses ◽  
Memory B Cell ◽  
Antibody Avidity ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory ◽  
Iga Antibodies ◽  
Specific Igg

ABSTRACTAntibody avidity for antigens following disease or vaccination increases with affinity maturation and somatic hypermutation. In this study, we followed children and adults in Bangladesh for 1 year following oral cholera vaccination and measured the avidity of antibodies to the T cell-dependent antigen cholera toxin B subunit (CTB) and the T cell-independent antigen lipopolysaccharide (LPS) in comparison with responses in other immunological measurements. Children produced CTB-specific IgG and IgA antibodies of high avidity following vaccination, which persisted for several months; the magnitudes of responses were comparable to those seen in adult vaccinees. The avidity of LPS-specific IgG and IgA antibodies in vaccinees increased significantly shortly after the second dose of vaccine but waned rapidly to baseline levels thereafter. CTB-specific memory B cells were present for only a short time following vaccination, and we did not find significant memory B cell responses to LPS in any age group. For older children, there was a significant correlation between CTB-specific memory T cell responses after the second dose of vaccine and CTB-specific IgG antibody avidity indices over the subsequent year. These findings suggest that vaccination induces a longer-lasting increase in the avidity of antibodies to a T cell-dependent antigen than is measured by a memory B cell response to that antigen and that early memory T cell responses correlate well with the subsequent development of higher-avidity antibodies.

Belatacept Can Inhibit Allo-Specific T Cell Responses in a Donor-Dependent Manner But Preserves Virus-Specific Memory T Cell-Responses.

2014 ◽  
Vol 98 ◽  
pp. 36
Author(s):  
C. Falk ◽  
K. Daemen ◽  
M. Stevanovic-Meyer ◽  
F. Lehner ◽  
H. Haller ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Dependent Manner ◽  
Memory T Cell ◽  
Cell Responses ◽  
Specific Memory

scholarly journals Persistent Cellular Immunity to SARS-CoV-2 Infection

2020 ◽  
Author(s):  
Gaëlle Breton ◽  
Pilar Mendoza ◽  
Thomas Hagglof ◽  
Thiago Y. Oliveira ◽  
Dennis Schaefer-Babajew ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Cell Division ◽  
T Cell ◽  
T Cell Responses ◽  
Memory T Cell ◽  
Cell Responses ◽  
Paired Samples ◽  
Specific Memory ◽  
Immune Alterations

AbstractSARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4+ and CD8+ T cells, expression of activation/exhaustion markers, and cell division.SummaryWe show that SARS-CoV-2 infection elicits broadly reactive and highly functional memory T cell responses that persist 6 months after infection. In addition, recovered individuals show enduring immune alterations in CD4+ and CD8+ T cells compartments.

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