Determination of the Optimal Dose of Calcineurin Inhibitor for Immunosuppressive Therapy with Basiliximab in Kidney Transplantation

2012 ◽  
Vol 94 (10S) ◽  
pp. 601
Author(s):  
H. Iwamoto ◽  
H. Takeuchi ◽  
Y. Nakamura ◽  
T. Suzuki ◽  
G. Muhetaer ◽  
...  
2009 ◽  
Vol 87 (12) ◽  
pp. 1821-1829 ◽  
Author(s):  
Georg Heinze ◽  
Rainer Oberbauer ◽  
Alexander Kainz ◽  
Christa Mitterbauer ◽  
Christian Koppelstaetter ◽  
...  

Vestnik ◽  
2021 ◽  
pp. 136-142
Author(s):  
Б.Г. Султанова ◽  
И.Б. Мансурова ◽  
С.Б. Бодесова ◽  
Н.С. Джуманов ◽  
Ш.А. Сарсенова ◽  
...  

В статье приведен литературный обзор, посвященный современным проблемам в трансплантологии почек. Нерешенными проблемами остаются оценка донора, низкая приверженность пациентов иммуносупрессивной терапии и развитие дисфункции трансплантата. Развивающиеся осложнения после трансплантации и иммуносупрессивной терапии требуют междисциплинарного подхода в лечении и наблюдении реципиентов донорской почки. Также необходимо широкое развитие трупного донорства для снижения числа потенциальных пациентов с хронической болезнью почек. The article presents a literature review of contemporary problems in kidney transplantation. Donor evaluation, low adherence of patients to immunosuppressive therapy and the development of graft dysfunction remain as unresolved problems. Developing complications after transplantation and immunosuppressive therapy require an interdisciplinary approach in the treatment and monitoring of recipients of donor kidney. It is also indispensable to the development of cadaveric donation to reduce the number of potential patients with chronic kidney disease.


Author(s):  
V. A. Fedulkina ◽  
A. V. Vatazin ◽  
A. V. Kildyushevskiy ◽  
A. B. Zulkarnayev ◽  
D. V. Gubina ◽  
...  

Transplantation in elderly patients is obviously more challenging due to existing underlying diseases, changes in pharmacokinetics of immunosuppressive drugs, polypragmasy, and transformation of immunoreactivity (immunosenescence). Our review presents data on modification of adaptive and innate immunity during aging. It also considers the possibility of both reduced and adapted immunosuppressive therapy in elderly renal transplant recipients in achieving an optimal balance between efficacy and complications.


2021 ◽  
Vol 14 (9) ◽  
pp. 2992-3000
Author(s):  
Amos Miningou ◽  
Vanessa Golane ◽  
Appolinaire Sy Traore ◽  
Hyacinthe Kambire

The decrease in soil fertility is the main cause of low crops yields in Burkina Faso. It is therefore necessary to make a supply of fertilizers to increase yields. This is the reason why during the 2015 rainy season from July to October, a study was conducted on sesame fertilization in Souri located in the Province du Mouhoun. The goal of our study is to fertilize plants with increasing doses of mineral fertilizers at different application dates on sesame. The objective is to determine the optimum dose and date of fertilizer application to increase the yields. For this purpose four NPK (14-23-14) fertilizer treatments have been experimented with following doses NPK0 (0kg.ha-1), NPK50 (50 kg.ha-1) NPK100 (100kg.ha-1) NPK150 (150 kg.ha-1) with three application dates (sowing, 15 DAS, 30 DAS) in Fisher’s completely randomized blocks with four replications in split-plot. The results showed that NPK doses had an effect on sesame throughout morphological development (height, number of ramifications, number of capsules) and yield performance. Yields have increased according to the doses applied in the following order: NPK0 (226 kg.ha-1) < NPK50 (348 kg.ha-1) <NPK100 (550 kg.ha-1) <NPK150 (593 kg.ha-1). Through economic calculations, the NPK100 dose with 550 kg.ha-1 yield can be chosen as the most cost-effective dose for producers. The application dates of NPK had various effects on sesame that emerged on the height and grain yield. The plants had the best performance on the date of application of the 15 DAS (475 kg.ha-1) followed by the application at planting time (450 kg.ha-1) and at the end the application on 30 DAS (375 kg.ha-1). Interaction between the doses and the dates of application of fertilizer is significant and should be considered in sesame. La baisse de la fertilité des sols est une cause des faibles rendements au Burkina Faso. Ainsi, il faudra faire de bons apports d’engrais pour augmenter les rendements. Dans ce cadre, une étude a été conduite de juillet à octobre 2015 à Souri dans la Province du Mouhoun. Il s’est agi d’apporter des doses croissantes de fumure minérale à différentes dates d’application sur le sésame. L’objectif est de déterminer la dose et la date d’application optimales de la fumure minérale. A cet effet quatre traitements de doses d’engrais NPK (14-23-14) : NPK0 (0 kg.ha-1), NPK50 (50 kg.ha-1), NPK100 (100kg.ha-1), NPK150 (150 kg.ha-1) ont été appliqués selon trois dates d’application (au semis, le 15ème JAS, le 30ème JAS) dans un dispositif expérimental en blocs de Fisher à 4 répétitions avec un arrangement en split-plot. Les résultats obtenus ont montré que les doses NPK ont un effet positif sur le sésame à travers son développement morphologique (sa hauteur, ses ramifications, ses capsules) et son rendement. Les rendements obtenus ont permis de classer les doses selon cet ordre croissant : NPK0 (266 kg.ha-1) <NPK50 (348 kg.ha-1) <NPK100 (550 kg.ha-1) <NPK150 (593kg.ha-1). L’évaluation économique effectuée sur la base du ratio valeur sur coût (RVC) a permis de retenir la dose NPK100 comme étant la plus rentable pour les producteurs. Les dates d’applications NPK sur le sésame ont également des effets visibles sur la hauteur et le rendement en grain. Le meilleur rendement est obtenu avec l’application du NPK 15 JAS (475 kg.ha-1) suivi de l’application au semis (450 kg.ha-1) et enfin de celle effectuée au 30ème JAS (375 kg.ha-1). L’interaction doses et dates d’application d’engrais NPK doit être considérée chez le sésame.


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