Alloreactive CD8 T Cells Process and Present Acquired MHC Class I Alloantigen To Indirect Pathway Helper CD4 T Cells.

2014 ◽  
Vol 98 ◽  
pp. 310
Author(s):  
E. Wlodek ◽  
A. Jason ◽  
K. Saeb-Parsy ◽  
M. Chhubra ◽  
G. Pettigrew
Keyword(s):  
T Cells ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Class I ◽  
Indirect Pathway

Role of MHC class I and CD8+ T cells in the pathogenesis of chronic rejection

2001 ◽  
Vol 33 (1-2) ◽  
pp. 319 ◽  
Author(s):  
H Sun ◽  
V Subbotin ◽  
J Woodward ◽  
L Valdivia ◽  
J.J Fung ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Chronic Rejection ◽  
Class I

scholarly journals Identification of an HLA-DQ6-derived peptide recognized by mouse MHC class I H-2Db-restricted CD8+ T cells in HLA-DQ6 transgenic mice

1997 ◽  
Vol 42 (1) ◽  
pp. 225-232 ◽  
Author(s):  
Tsutao Takeshita ◽  
Yoshinori Fukui ◽  
Ken Yamamoto ◽  
Kazuaki Yamane ◽  
Takeshi Inamitsu ◽  
...  
Keyword(s):  
T Cells ◽  
Transgenic Mice ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Class I

scholarly journals MHC class I-independent activation of virtual memory CD8 T cells induced by chemotherapeutic agent-treated cancer cells

2020 ◽  
Author(s):  
Xiaoguang Wang ◽  
Brittany C. Waschke ◽  
Rachel A. Woolaver ◽  
Samantha M. Y. Chen ◽  
Zhangguo Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Cancer Cells ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Chemotherapeutic Agent ◽  
Virtual Memory ◽  
Class I ◽  
Memory Cd8 T Cells

scholarly journals Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

2002 ◽  
Vol 196 (12) ◽  
pp. 1627-1638 ◽  
Author(s):  
Laura Bonifaz ◽  
David Bonnyay ◽  
Karsten Mahnke ◽  
Miguel Rivera ◽  
Michel C. Nussenzweig ◽  
...  
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Steady State ◽  
T Cell ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Class I ◽  
Histocompatibility Complex ◽  
Dc Maturation

To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues. Ovalbumin (OVA) protein, when chemically coupled to monoclonal αDEC-205 antibody, was presented by CD11c+ lymph node DCs, but not by CD11c− cells, to OVA-specific, CD4+ and CD8+ T cells. Receptor-mediated presentation was at least 400 times more efficient than unconjugated OVA and, for MHC class I, the DCs had to express transporter of antigenic peptides (TAP) transporters. When αDEC-205:OVA was injected subcutaneously, OVA protein was identified over a 4–48 h period in DCs, primarily in the lymph nodes draining the injection site. In vivo, the OVA protein was selectively presented by DCs to TCR transgenic CD8+ cells, again at least 400 times more effectively than soluble OVA and in a TAP-dependent fashion. Targeting of αDEC-205:OVA to DCs in the steady state initially induced 4–7 cycles of T cell division, but the T cells were then deleted and the mice became specifically unresponsive to rechallenge with OVA in complete Freund's adjuvant. In contrast, simultaneous delivery of a DC maturation stimulus via CD40, together with αDEC-205:OVA, induced strong immunity. The CD8+ T cells responding in the presence of agonistic αCD40 antibody produced large amounts of interleukin 2 and interferon γ, acquired cytolytic function in vivo, emigrated in large numbers to the lung, and responded vigorously to OVA rechallenge. Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation.

Abstract 1925: MHC class I-restricted MART-127-35 specific TCR engineered human CD4+ and CD8+ T cells exhibit polyfunctional properties

2010 ◽  
Author(s):  
Swagatam Ray ◽  
Arvind Chhabra ◽  
Nitya G. Chakraborty ◽  
Antoni Ribas ◽  
James S. Economou ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Class I
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