NM-23 Gene Loss of Heterozygosity and Protein Expression in High-Stage Laryngeal Squamous Cell Carcinomas

2006 ◽  
Vol 15 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Hina Sheikh ◽  
Justin Murphy ◽  
Jennifer L. Hunt
Keyword(s):  
Protein Expression ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Gene Loss ◽  
Squamous Cell Carcinomas ◽  
High Stage

Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

2008 ◽  
Vol 134 (12) ◽  
pp. 1267-1276 ◽  
Author(s):  
Davut Pehlivan ◽  
Esra Gunduz ◽  
Mehmet Gunduz ◽  
Hitoshi Nagatsuka ◽  
Levent Bekir Beder ◽  
...  
Keyword(s):  
Head And Neck ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Squamous Cell Carcinomas ◽  
Chromosome 14Q

scholarly journals Black raspberry restores the expression of the tumor suppressor p120ctn in the oral cavity of mice treated with the carcinogen dibenzo[a,l]pyrene diol epoxide

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259998
Author(s):  
Douglas B. Stairs ◽  
Mary E. Landmesser ◽  
Cesar Aliaga ◽  
Kun-Ming Chen ◽  
Yuan-Wan Sun ◽  
...  
Keyword(s):  
Protein Expression ◽  
Squamous Cell ◽  
Immune Cells ◽  
Active Metabolite ◽  
Squamous Cell Carcinomas ◽  
Tobacco Smoke Exposure ◽  
Black Raspberry ◽  
Chemopreventive Agent ◽  
Diol Epoxide ◽  
Egfr Expression

One of the major risk factors for head and neck squamous cell carcinoma (HNSCC) is tobacco smoke exposure, but the mechanisms that can account for disease development remain to be fully defined. Utilizing our HNSCC mouse model, we analyzed oral squamous cell carcinomas (OSCC) induced by the active metabolite of a common smoke constituent, dibenzo[a,l]pyrene diol-epoxide (DBPDE). Analyzing protein expression by either immunofluorescence or immunohistochemistry, we identified biologic processes that are dysregulated in premalignant and invasive cancer lesions induced by DBPDE. Interestingly, p120ctn expression is downregulated in both stages of the disease. In addition to decreased p120ctn expression, there was also increased proliferation (as measured by Ki67), inflammation (as measured by NFkB (p65) expression), neovascularization (as measured by CD31) and recruitment of Ly6G-positive immune cells as well as strong EGFR expression. We also examined the effect of the chemopreventive agent black raspberry (BRB) on p120ctn and EGFR protein expression in DBPDE treated mice. p120ctn, but not EGFR, protein expression increased in mice treated with BRB. Our results suggest that modulation of p120ctn may, in part, account for the mechanism by which BRB inhibits DBPDE induced OSCC in mice.

scholarly journals Loss of Heterozygosity of 3p21 and 9p21 in Head and Neck Squamous Cell Carcinomas and its Prognostic Implication.

1999 ◽  
Vol 102 (5) ◽  
pp. 613-621 ◽  
Author(s):  
Kazuto Matsuura ◽  
Kiyoto Shiga ◽  
Junkichi Yokoyama ◽  
Masaru Tateda ◽  
Hiroshi Nakano ◽  
...  
Keyword(s):  
Head And Neck ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Prognostic Implication

Immunohistochemical evaluation of Fhit protein expression in oral squamous cell carcinomas

2007 ◽  
Vol 28 (10) ◽  
pp. 433-437 ◽  
Author(s):  
W. F. P. Heerden ◽  
T. J. P. Swart ◽  
M. B. Heerden ◽  
E. J. Rensburg ◽  
S. Engelbrecht ◽  
...  
Keyword(s):  
Protein Expression ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
Fhit Protein

Analysis of αv integrin protein expression in human eyelid and periorbital squamous cell carcinomas

2011 ◽  
Vol 38 (7) ◽  
pp. 570-575 ◽  
Author(s):  
Adam Hsu ◽  
Bita Esmaeli ◽  
Brent Hayek ◽  
Mohammad G. Hossain ◽  
Roman Shinder ◽  
...  
Keyword(s):  
Protein Expression ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas

Frequent loss of heterozygosity on chromosome 9 in Chinese esophageal squamous cell carcinomas

2004 ◽  
Vol 203 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Yang Lichun ◽  
Cecilia Man Ching Tang ◽  
Kwok Wai Lau ◽  
Maria Li Lung
Keyword(s):  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Chromosome 9 ◽  
Esophageal Squamous Cell Carcinomas
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