Helicobacter pylori infestation in gastric ulcer disease

Aim: To study the association of Helicobacter pylori infection with chronic antral gastritis in peptic ulcer disease patients and healthy population of Kashmir.Methods: 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combined duodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included in this study. Peptic ulcer was diagnosed on endoscopic examination. 4–6 punch biopsies were taken from gastric antrum in all the individuals and in case of gastric ulcer an additional biopsy was taken from the edge of the ulcer to exclude its malignant nature. Helicobacter pylori (H. pylori) organism was diagnosed using three different test methods, viz. Histology (using Giemsa Stain), Microbiology (Gram Stain) and Biochemistry (using one minute Endoscopy Room Test). Histological diagnosis of H. pylori was taken as the “gold standard” for the presence of H. pylori organism. Histological diagnosis of gastritis was made using Hematoxylin and Eosin Stain and the gastritis was classified as active chronic gastritis and superficial chronic gastritis.Results: Out of 30 peptic ulcer disease patients with associated antral gastritis, 27 (90%) were positive for H. pylori on histological examination (13 superficial chronic gastritis and 14 active chronic gastritis) whereas out of 8 healthy volunteers with histological evidence of chronic antral gastritis, H. pylori was observed in 7 individuals (87.50%) (4 active chronic gastritis and 3 superficial chronic gastritis).Conclusion: A highly significant association between H. pylori infection with chronic antral gastritis both in peptic ulcer disease patients and healthy volunteers of Kashmir was found in this study. Association between H. pylori infection and chronic gastritis was 90% in peptic ulcer group and 87.50% in healthy population (P<0.005).

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Draft Genome Sequences of Helicobacter pylori Strains HPARG63 and HPARG8G, Cultured from Patients with Chronic Gastritis and Gastric Ulcer Disease

Genome Announcements ◽

10.1128/genomea.00700-13 ◽

2013 ◽

Vol 1 (5) ◽

Author(s):

R. I. Armitano ◽

G. Zerbetto De Palma ◽

M. J. Matteo ◽

S. Revale ◽

S. Romero ◽

...

Keyword(s):

Helicobacter Pylori ◽

Gastric Ulcer ◽

Chronic Gastritis ◽

Draft Genome ◽

Genome Sequences ◽

Ulcer Disease

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Haplotype analysis of the CD11 gene cluster in patients with chronic Helicobacter pylori infection and gastric ulcer disease

Tissue Antigens ◽

10.1111/j.1399-0039.2005.00362.x ◽

2005 ◽

Vol 65 (3) ◽

pp. 271-274 ◽

Cited By ~ 12

Author(s):

S. Hellmig ◽

S. Mascheretti ◽

J. Renz ◽

H. Frenzel ◽

F. Jelschen ◽

...

Keyword(s):

Helicobacter Pylori ◽

Gastric Ulcer ◽

Gene Cluster ◽

Haplotype Analysis ◽

Helicobacter Pylori Infection ◽

Ulcer Disease

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Cure of gastric ulcer disease after cure of Helicobacter pylori infection - German gastric ulcer study

European Journal of Gastroenterology & Hepatology ◽

10.1097/00042737-199604000-00011 ◽

1996 ◽

Vol 8 (4) ◽

pp. 343-350 ◽

Cited By ~ 11

Author(s):

Ekkehard Bayerdörffer ◽

Stephan Miehlke ◽

Norbert Lehn ◽

Gerd A. Mannes ◽

Wilhelm Höchter ◽

...

Keyword(s):

Helicobacter Pylori ◽

Gastric Ulcer ◽

Helicobacter Pylori Infection ◽

Ulcer Disease

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Better Outcome in Laparoscopic Gastric Ulcer Perforation Than Laparotomy : Single Center Experience

Medical & Clinical Research ◽

10.33140/mcr.02.04.04 ◽

2017 ◽

Vol 2 (4) ◽

Keyword(s):

Helicobacter Pylori ◽

Risk Factor ◽

Gastric Ulcer ◽

Seasonal Variation ◽

Single Center ◽

Ulcer Disease ◽

Single Center Experience ◽

The World ◽

Inflammatory Drugs ◽

H Pylori

Each year gastric ulcer disease (PUD) affects 4 million people around the world. Complications are encountered in 10%-20% of these patients and 2%-14% of the ulcers will perforate [1]. Females account for more than half the cases, they are older and have more comorbidity than their male counterparts. Main etiologic factors include use of non-steroidal anti-inflammatory drugs (NSAIDs), steroids, smoking, Helicobacter pylori (H. pylori) and a diet high in salt. All these factors have in common that they affect acid secretion in the gastric mucosa. Defining the exact etiological factor in any given patient may often be difficult, as more than one risk factor may be present and they tend to interact [2]. While previous reports have shown a seasonal variation in the incidence of PPU, others have failed to find such a pattern [3].

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