#711 Cerebral vein thrombosis in a patient with severe iron deficiency anemia, protein losing enteropathy, and factor V Leiden mutation

1998 ◽  
Vol 20 (4) ◽  
pp. 414
Author(s):  
C. Blanchong ◽  
K. Klopfenstein ◽  
F. Ruymann
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Factor V Leiden ◽  
Deficiency Anemia ◽  
Cerebral Vein ◽  
Factor V ◽  
Cerebral Vein Thrombosis ◽  
Protein Losing Enteropathy ◽  
Factor V Leiden Mutation ◽  
Vein Thrombosis

scholarly journals Deep cerebral vein thrombosis due to iron deficiency anemia: A case report

2016 ◽  
Vol 3 (3) ◽  
pp. 4
Author(s):  
Nao Nishida ◽  
Yoshimasa Sueda ◽  
Tomomi Kanbara ◽  
Takashi Kurashige ◽  
Tsuyoshi Torii
Keyword(s):  
Case Report ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Young Women ◽  
Deficiency Anemia ◽  
Central Vein ◽  
Cerebral Vein ◽  
Common Condition ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis

We report on a 28-year-old woman who developed deep cerebral vein thrombosis (CVT) associated with iron deficiency anemia (IDA). Activation of platelet function by IDA may lead to CVT and sometimes results in death when a deep central vein is affected. While IDA is a common condition, especially among young women, proper management of IDA is needed to prevent severe venous thrombosis.

Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis

Blood ◽  
2006 ◽  
Vol 107 (7) ◽  
pp. 2766-2773 ◽  
Author(s):  
Francesco Dentali ◽  
Mark Crowther ◽  
Walter Ageno
Keyword(s):  
Oral Contraceptives ◽  
Meta Analysis ◽  
Factor V Leiden ◽  
Cochrane Library ◽  
Cerebral Vein ◽  
Factor V ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis ◽  
Increased Risk ◽  
Study Characteristics

AbstractRecent studies suggest that thrombophilic abnormalities and the use of oral contraceptives (OCs) are the leading causes of cerebral vein thrombosis (CVT). The purpose of this study was to assess the association between CVT and thrombophilic states, OCs, and their interaction. For data sources, we used the MEDLINE, EMBASE, and Cochrane Library databases (January 1994 to March 2005), reference lists of retrieved articles, and contact with content experts. We selected studies comparing the prevalence of OC use and the prevalence of prothrombitic abnormalities in patients with CVT compared with healthy controls. Two reviewers independently selected studies and extracted study characteristics, quality, and outcomes. Odds ratios (ORs) were calculated for each trial and pooled using the Mantel-Haenszel method. Seventeen studies were included. There was an increased risk of CVT in patients using OCs (OR 5.59; 95% confidence interval [CI] 3.95 to 7.91; P < .001), and in patients with factor V Leiden (OR 3.38; 95% CI 2.27 to 5.05; P < .001), with mutation G20 210A of prothrombin (OR 9.27; 95% CI 5.85 to 14.67; P < .001) and with hyperhomocysteinemia (OR 4.07; 95% CI 2.54 to 6.52; P < .001). We concluded that OC users, and patients with factor V Leiden, the prothrombin G20 120A mutation, and hyperhomocysteinemia are at a significantly increased risk of CVT.

Hypercoagulation Testing in Ischemic Stroke

2007 ◽  
Vol 131 (6) ◽  
pp. 890-901
Author(s):  
Aliyah Rahemtullah ◽  
Elizabeth M. Van Cott
Keyword(s):  
Ischemic Stroke ◽  
Laboratory Testing ◽  
Recurrent Stroke ◽  
Factor V Leiden ◽  
Protein S ◽  
Prothrombin G20210a ◽  
Cerebral Vein ◽  
Factor V ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis

Abstract Context.—The utility of laboratory testing for hypercoagulability in the setting of stroke is uncertain. Objective.—To review the current literature and to make recommendations with regard to laboratory testing for various hypercoagulability risk factors for ischemic stroke. Data Sources.—Published articles studying the utility of various hypercoagulation tests in predicting initial and/or recurrent stroke or transient ischemic attack as well as cerebral vein thrombosis were collected and reviewed, with an emphasis on prospective studies. Conclusions.—Certain tests, such as C-reactive protein, homocysteine, antiphospholipid antibodies, and lipoprotein(a), may be useful in patients with a history of stroke or at high risk for stroke, as evidenced by prospective data. Factor V Leiden, prothrombin G20210A, protein C, protein S, and antithrombin are not recommended for routine testing but may be useful in certain populations, such as in pediatric patients or in patients with cerebral vein thrombosis.

Prospective Evaluation of the Prevalence of Factor V Leiden Mutation in Portal or Hepatic Vein Thrombosis

1997 ◽  
Vol 78 (04) ◽  
pp. 1297-1298 ◽  
Author(s):  
Marie-Hélène Denninger ◽  
Dominique Helley ◽  
Dominique Valla ◽  
Marie-Claude Guillin
Keyword(s):  
Hepatic Vein ◽  
Factor V Leiden ◽  
Factor V ◽  
Prospective Evaluation ◽  
Factor V Leiden Mutation ◽  
Vein Thrombosis ◽  
Hepatic Vein Thrombosis

scholarly journals The Consequence of Excessive Consumption of Cow’s Milk: Protein-Losing Enteropathy with Anasarca in the Course of Iron Deficiency Anemia—Case Reports and a Literature Review

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 828
Author(s):  
Karolina Graczykowska ◽  
Joanna Kaczmarek ◽  
Dominika Wilczyńska ◽  
Ewa Łoś-Rycharska ◽  
Aneta Krogulska
Keyword(s):  
Iron Deficiency ◽  
Literature Review ◽  
Iron Deficiency Anemia ◽  
Case Reports ◽  
Deficiency Anemia ◽  
Cow’S Milk ◽  
Milk Consumption ◽  
Protein Losing Enteropathy ◽  
Cow's Milk ◽  
Excessive Consumption

Cow’s milk is a key component of a child’s diet. While the consumption of even trace amounts can result in allergy to its proteins and/or hypolactasia, excessive cow’s milk consumption can result in numerous health complications, including iron deficiency, due to the diet being improperly balanced. Although the incidence of iron deficiency has declined, it remains the most widespread nutritional deficiency globally and the most common cause of anemia. One rare consequence of anemia caused by iron deficiency is protein-losing enteropathy; however, the mechanisms of its development are unclear. The following manuscript, based on a literature review, presents two rare cases of children, a 16-month-old boy and a 2.5-year-old girl, who developed severe microcytic anemia, enteropathy with hypoalbuminemia, and anasarca as a result of excessive cow’s milk consumption. It highlights the possible relationship between excessive consumption of cow’s milk in children and severe iron deficiency anemia with accompanying hypoalbuminemia; it may also result in serious clinical conditions, even in children that do not demonstrate food hypersensitivity.

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