Multicenter Comparison of Magnetic Resonance Imaging and Transcranial Doppler Ultrasonography in the Evaluation of the Central Nervous System in Children With Sickle Cell Disease

2000 ◽  
Vol 22 (4) ◽  
pp. 335-339 ◽  
Author(s):  
Winfred C. Wang ◽  
Dianne M. Gallagher ◽  
Charles H. Pegelow ◽  
Elizabeth C. Wright ◽  
Elliott P. Vichinsky ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Sickle Cell Disease ◽  
Transcranial Doppler ◽  
Doppler Ultrasonography ◽  
Resonance Imaging ◽  
Cell Disease ◽  
The Central Nervous System

scholarly journals Toxicity of Shiga Toxin 1 in the Central Nervous System of Rabbits

2001 ◽  
Vol 69 (10) ◽  
pp. 6545-6548 ◽  
Author(s):  
Jun Fujii ◽  
Yoshimasa Kinoshita ◽  
Takashi Yutsudo ◽  
Hatsumi Taniguchi ◽  
Tom Obrig ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Spinal Cord ◽  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Shiga Toxin ◽  
Brain Lesions ◽  
Resonance Imaging ◽  
The Central Nervous System

ABSTRACT The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2. Magnetic resonance imaging demonstrated a predominance of Stx1-dependent lesions in the spinal cord. Pretreatment of the animals with anti-Stx1 antiserum intravenously completely protected against both development of brain lesions and mortality.

Sign in / Sign up

Export Citation Format

Share Document