EFFECT OF CAROTID SINUS STIMULATION ON THE ELECTROCARDIOGRAMS OF CLINICALLY NORMAL INDIVIDUALS

1957 ◽  
Vol 1 (3) ◽  
pp. 209-211
Author(s):  
G. H. HEIDORN ◽  
A. P. MCNAMARA
Keyword(s):  
Carotid Sinus ◽  
Clinically Normal ◽  
Carotid Sinus Stimulation ◽  
Normal Individuals

scholarly journals Studies of T-lymphocytes in preleukemic disorders and acute nonlymphocytic leukemia: in vitro radiosensitivity, mitogenic responsiveness, colony formation, and enumeration of lymphocytic subpopulations

Blood ◽  
1983 ◽  
Vol 61 (3) ◽  
pp. 449-455 ◽  
Author(s):  
SJ Knox ◽  
BR Greenberg ◽  
RW Anderson ◽  
LS Rosenblatt
Keyword(s):  
Whole Blood ◽  
Colony Formation ◽  
Tritiated Thymidine ◽  
Lymphocyte Stimulation Test ◽  
Acute Nonlymphocytic Leukemia ◽  
Clinically Normal ◽  
Normal Individuals ◽  
Increased Risk ◽  
X Irradiation

Abstract Tritiated thymidine incorporation in a whole blood lymphocyte stimulation test (LST) and lymphocyte colony formation (CFU-L) from whole blood were measured following in vitro x-irradiation. Lymphocytes from patients with myelodysplastic disorders, acute nonlymphocytic leukemia, and patients at increased risk for leukemia because of their primary disease and/or cytotoxic therapy were found to be significantly more sensitive to in vitro x-irradiation than lymphocytes from clinically normal individuals. Cloning efficiencies and mitogenic responsiveness of patient lymphocytes were significantly depressed as compared to normal values. Using monoclonal antibodies to specific surface markers, quantitative abnormalities in lymphocytic subpopulations from myelodysplastic patients also were observed. These findings are suggestive of a defect at the T-cell level that may directly or indirectly affect hematopoiesis.

Carotid sinus depressor reflexes during hypothermia

1964 ◽  
Vol 207 (4) ◽  
pp. 777-781 ◽  
Author(s):  
J. E. Kendrick ◽  
Kenneth A. Turner
Keyword(s):  
Smooth Muscle ◽  
Carotid Sinus ◽  
Baroreceptor Reflex ◽  
The Body ◽  
Lower Body ◽  
Body Temperatures ◽  
Small Reduction ◽  
Local Cooling ◽  
Carotid Sinus Stimulation ◽  
Reflex Arc

Reducing body temperature in dogs to 24 C caused a small reduction in the size of the carotid sinus depressor response. Along with this reduction the response also became more gradual at the lower body temperatures. Systematic studies demonstrated that the more gradual nature of the response appeared to result from changes in the vascular smooth muscle. Depression of the nervous elements of the baroreceptor reflex arc during hypothermia was not evident. The response to carotid sinus stimulation in the warm, perfused hindlimb was essentially unchanged by cooling the body to 24 C. Local cooling of the perfused hindleg did not reduce the size but did result in a more gradual response.

scholarly journals Effect of head up tilt on response to carotid sinus stimulation in patients with recurrent syncope

1998 ◽  
Vol 31 ◽  
pp. 37
Author(s):  
R. Krol ◽  
S. Saksena ◽  
A. Prakash ◽  
G. Krol ◽  
P. Default ◽  
...  
Keyword(s):  
Carotid Sinus ◽  
Carotid Sinus Stimulation ◽  
Head Up Tilt

scholarly journals Coronary artery spasm induced by carotid sinus stimulation during neck surgery

2003 ◽  
Vol 90 (3) ◽  
pp. 391-394 ◽  
Author(s):  
S.S. Choi ◽  
Y.-J. Lim ◽  
J.-H. Bahk ◽  
S.-H. Do ◽  
B.-M. Ham
Keyword(s):  
Coronary Artery ◽  
Carotid Sinus ◽  
Coronary Artery Spasm ◽  
Neck Surgery ◽  
Carotid Sinus Stimulation

scholarly journals Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism

2020 ◽  
Vol 52 (06) ◽  
pp. 421-426
Author(s):  
Celso E. Gomez-Sanchez ◽  
Elise P. Gomez-Sanchez ◽  
Koshiro Nishimoto
Keyword(s):  
Somatic Mutations ◽  
Older Individuals ◽  
Clinically Normal ◽  
Normal People ◽  
Normal Individuals ◽  
Continuous Band ◽  
Aldosterone Production ◽  
Heterogeneous Expression ◽  
Normal Humans ◽  
Aldosterone Producing Adenoma

AbstractThe CYP11B2 enzyme is the terminal enzyme in the biosynthesis of aldosterone. Immunohistochemistry using antibodies against CYP11B2 defines cells of the adrenal ZG that synthesize aldosterone. CYP11B2 expression is normally stimulated by angiotensin II, but becomes autonomous in primary hyperaldosteronism, in most cases driven by recently discovered somatic mutations of ion channels or pumps. Cells expressing CYP11B2 in young normal humans form a continuous band beneath the adrenal capsule; in older individuals they form discrete clusters, aldosterone-producing cell clusters (APCC), surrounded by non-aldosterone producing cells in the outer layer of the adrenal gland. Aldosterone-producing adenomas may exhibit a uniform or heterogeneous expression of CYP11B2. APCC frequently persist in the adrenal with an aldosterone-producing adenoma suggesting autonomous CYP11B2 expression in these cells as well. This was confirmed by finding known mutations that drive aldosterone production in adenomas in the APCC of clinically normal people. Unilateral aldosteronism may also be due to multiple CYP11B2-expressing nodules of various sizes or a continuous band of hyperplastic ZG cells expressing CYP11B2. Use of CYP11B2 antibodies to identify areas for sequencing has greatly facilitated the detection of aldosterone-driving mutations.

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