II–3 The Role of the Medical Social Worker (MSW) to Introduce and Continue Low Intensity Pulsed Ultrasound (LIPUS) Treatment

Objective: To systematically review the role of low-intensity pulsed ultrasound on lumbar spondylolysis. Method: Literature search was conducted on PubMed, Embase, CINAHL, Web of Science, PEDro and Scopus databases to identify relevant studies published between 2010 and 2020 by using medical subject headings and applying Booleans, such as low-intensity pulsed ultrasound OR interventional ultrasound AND lumbar spine OR lumbar region AND spondylolysis OR stress fracture. Unpublished studies were hand-searched in the journals, abstracts of conferences were reviewed, and citation index was used for searching experts in the field and then contacting them for information. Studies included were the ones that had at least one of the following outcomes: bone union rate, treatment period to bone union and time to return to previous activities. Results: Of the 243 studies identified, 228(94%) were full text articles and only 2(0.8%) studies were critically appraised for qualitative synthesis based on bone union rate, treatment period to bone union, and time to return to previous activities. Conclusion: Low-intensity pulsed ultrasound was found to be effective for bone union and a useful therapy for quick return to playing sports in patients with lumbar spondylolysis. Key Words: Lumbar region, Spondylolysis, Interventional ultrasound, Systematic review.

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The Role of Low-Intensity Pulsed Ultrasound on Cartilage Healing in Knee Osteoarthritis: A Review

PM&R ◽

10.1016/j.pmrj.2017.05.008 ◽

2017 ◽

Vol 9 (12) ◽

pp. 1268-1277 ◽

Cited By ~ 10

Author(s):

Joshua B. Rothenberg ◽

Prathap Jayaram ◽

Usker Naqvi ◽

Joslyn Gober ◽

Gerard A. Malanga

Keyword(s):

Knee Osteoarthritis ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity ◽

Cartilage Healing

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Low-intensity pulsed ultrasound-dependent osteoblast proliferation occurs by via activation of the P2Y receptor: Role of the P2Y1 receptor

Bone ◽

10.1016/j.bone.2009.09.017 ◽

2010 ◽

Vol 46 (2) ◽

pp. 355-362 ◽

Cited By ~ 43

Author(s):

Érika Costa Alvarenga ◽

Renata Rodrigues ◽

Afonso Caricati-Neto ◽

Fernando Costa Silva-Filho ◽

Edgar J. Paredes-Gamero ◽

...

Keyword(s):

P2y Receptor ◽

P2y1 Receptor ◽

Osteoblast Proliferation ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity

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Role of the tumor necrosis factor-α, cyclooxygenase-2, prostaglandin E2, and effect of low-intensity pulsed ultrasound in an in vitro herniated disc resorption model

Journal of Orthopaedic Research® ◽

10.1002/jor.20525 ◽

2008 ◽

Vol 26 (9) ◽

pp. 1274-1278 ◽

Cited By ~ 14

Author(s):

Sadahiro Iwabuchi ◽

Masaya Ito ◽

Toshihiro Chikanishi ◽

Yoshiaki Azuma ◽

Hirotaka Haro

Keyword(s):

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Herniated Disc ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity ◽

Factor Α ◽

Necrosis Factor

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Acceleration of Bone-Tendon Interface Healing by Low-Intensity Pulsed Ultrasound Is Mediated by Macrophages

Physical Therapy ◽

10.1093/ptj/pzab055 ◽

2021 ◽

Author(s):

Shengcan Li ◽

Zihan Xu ◽

Zhanwen Wang ◽

Jie Xiang ◽

Tao Zhang ◽

...

Keyword(s):

Rotator Cuff ◽

Bone Quality ◽

Ultrasonic Treatment ◽

Supraspinatus Tendon ◽

Control Group ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity ◽

Liposomal Clodronate

Abstract Objective Low-intensity pulsed ultrasound (LIPUS) has been proven to facilitate bone-tendon interface (BTI) healing and regulate some inflammatory cytokines. However, the role of macrophages, a key type of inflammatory cell, during treatment remains unknown. This study aimed to investigate the role of macrophages in the treatment of BTI injury with LIPUS in a rotator cuff tear animal model. Methods In this experimental and comparative study, a total of 160 C57BL/6 mature male mice that underwent supraspinatus tendon detachment and repair were randomly assigned to 4 groups: daily ultrasonic treatment and liposomal clodronate (LIPUS+LC), daily ultrasonic treatment and liposomes (LIPUS), daily mock sonication and liposomal clodronate (LC), and daily mock sonication and liposomes (control). LIPUS treatment was initiated immediately postoperatively and continued daily until the end of the experimental period. Results The failure load and stiffness of the supraspinatus tendon–humerus junction were significantly higher in the LIPUS group than in the other groups at postoperative weeks 2 and 4, whereas those in the LIPUS+LC and LC groups were lower than those in the control group at postoperative week 4. The LIPUS, LIPUS+LC, and LC groups exhibited significantly more fibrocartilage than the control group at 2 weeks. Only the LIPUS group had more fibrocartilage than the control group at 4 weeks. Micro–computed tomography results indicated that LIPUS treatment could improve the bone quality of the attachment site after both 2 and 4 weeks. When macrophages were depleted by LC, the bone quality–promoting effect of LIPUS treatment was significantly reduced. Conclusions The enhancement of BTI healing by LIPUS might be mediated by macrophages. Impact In our study, LIPUS treatment appeared to accelerate BTI healing, which was associated with macrophages based on our murine rotator cuff repair model. The expressions of macrophage under LIPUS treatment may offer a potential mechanism to explain BTI healing and the effects of LIPUS on BTI healing.

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