Role of low-intensity pulsed ultrasound on lumbar spondylolysis: a systematic review

Objective: To systematically review the role of low-intensity pulsed ultrasound on lumbar spondylolysis. Method: Literature search was conducted on PubMed, Embase, CINAHL, Web of Science, PEDro and Scopus databases to identify relevant studies published between 2010 and 2020 by using medical subject headings and applying Booleans, such as low-intensity pulsed ultrasound OR interventional ultrasound AND lumbar spine OR lumbar region AND spondylolysis OR stress fracture. Unpublished studies were hand-searched in the journals, abstracts of conferences were reviewed, and citation index was used for searching experts in the field and then contacting them for information. Studies included were the ones that had at least one of the following outcomes: bone union rate, treatment period to bone union and time to return to previous activities. Results: Of the 243 studies identified, 228(94%) were full text articles and only 2(0.8%) studies were critically appraised for qualitative synthesis based on bone union rate, treatment period to bone union, and time to return to previous activities. Conclusion: Low-intensity pulsed ultrasound was found to be effective for bone union and a useful therapy for quick return to playing sports in patients with lumbar spondylolysis. Key Words: Lumbar region, Spondylolysis, Interventional ultrasound, Systematic review.

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The Role of Low Intensity Pulsed Ultrasound Therapy in the Management of Acute Fractures: A Systematic Review

Journal of Trauma and Acute Care Surgery ◽

10.1097/ta.0b013e318185e222 ◽

2008 ◽

Vol 65 (6) ◽

pp. 1446-1452 ◽

Cited By ~ 33

Author(s):

Xavier L. Griffin ◽

Isabel Costello ◽

Matthew L. Costa

Keyword(s):

Systematic Review ◽

Ultrasound Therapy ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity

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Effect of low-intensity pulsed ultrasound on distraction osteogenesis: a systematic review and meta-analysis of randomized controlled trials

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-018-0907-x ◽

2018 ◽

Vol 13 (1) ◽

Cited By ~ 5

Author(s):

Shenghan Lou ◽

Houchen Lv ◽

Zhirui Li ◽

Peifu Tang ◽

Yansong Wang

Keyword(s):

Systematic Review ◽

Randomized Controlled Trials ◽

Distraction Osteogenesis ◽

Meta Analysis ◽

Controlled Trials ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity ◽

Randomized Controlled

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Impact of Ultrasound Therapy on Stem Cell Differentiation - A Systematic Review

Current Stem Cell Research & Therapy ◽

10.2174/1574888x15666200225124934 ◽

2020 ◽

Vol 15 (5) ◽

pp. 462-472 ◽

Cited By ~ 1

Author(s):

Abdollah Amini ◽

Sufan Chien ◽

Mohammad Bayat

Keyword(s):

Systematic Review ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Stem Cell ◽

Cell Differentiation ◽

Stem Cell Differentiation ◽

The Body ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity

Objective: This is a systematic review of the effects of low-intensity pulsed ultrasound (LIPUS) on stem cell differentiation. Background Data: Recent studies have investigated several types of stem cells from different sources in the body. These stem cells should strictly be certified and promoted for cell therapies before being used in medical applications. LIPUS has been used extensively in treatment centers and in research to promote stem cell differentiation, function, and proliferation. Materials and Methods: The databases of PubMed, Google Scholar, and Scopus were searched for abstracts and full-text scientific papers published from 1989-2019 that reported the application of LIPUS on stem cell differentiation. Related English language articles were found using the following defined keywords: low-intensity pulsed ultrasound, stem cell, differentiation. Criteria for inclusion in the review were: LIPUS with frequencies of 1–3 MHz and pulsed ultrasound intensity of <500 mW/cm2. Duration, exposure time, and cell sources were taken into consideration. Results: Fifty-two articles were selected based on the inclusion criteria. Most articles demonstrated that the application of LIPUS had positive effects on stem cell differentiation. However, some authors recommended that LIPUS combined with other physical therapy aides was more effective in stem cell differentiation. Conclusions: LIPUS significantly increases the level of stem cell differentiation in cells derived mainly from bone marrow mesenchymal stem cells. There is a need for further studies to analyze the effect of LIPUS on cells derived from other sources, particularly adipose tissue-derived mesenchymal stem cells, for treating hard diseases, such as osteoporosis and diabetic foot ulcer. Due to a lack of reporting on standard LIPUS parameters in the field, more experiments comparing the protocols for standardization of LIPUS parameters are needed to establish the best protocol, which would allow for the best results.

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Low Intensity Pulsed Ultrasound for Accelerating Distraction Osteogenesis: A Systematic Review of Experimental Animal Studies

Journal of Molecular and Clinical Medicine ◽

10.31083/j.jmcm.2018.02.012 ◽

2018 ◽

Vol 1 (2) ◽

Keyword(s):

Systematic Review ◽

Experimental Animal ◽

Distraction Osteogenesis ◽

Animal Studies ◽

Pulsed Ultrasound ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity

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Effects of Low-Intensity Pulsed Ultrasound on Pain and Functional Disability in Patients With Early-Stage Lumbar Spondylolysis: A Randomized Controlled Trial

10.21203/rs.3.rs-598951/v1 ◽

2021 ◽

Author(s):

Fahad Tanveer ◽

Syed Asadullah Arslan ◽

Haider Darain ◽

Ashfaq Ahmad ◽

Syed Amir Gilani ◽

...

Keyword(s):

Functional Disability ◽

Rating Scale ◽

Early Stage ◽

Controlled Trial ◽

Pulsed Ultrasound ◽

Invasive Treatment ◽

Low Intensity Pulsed Ultrasound ◽

Low Intensity ◽

Lumbar Spondylolysis

Abstract Background: Low Intensity Pulsed Ultrasound (LIPUS) is beneficial in accelerating fracture recovery, enhancing their capacity to execute tasks of daily life and, as a result, their autonomy. Methods: Thirty-four (29 males and 5 females) pre-diagnosed patients referred by an orthopaedic surgeon exhibiting symptomatic low back pain for at least four months were recruited and randomly divided into LIPUS group and Routine Physical Therapy (RPT) group. The lottery method was used to randomly assign patients into two groups. Numeric Pain Rating Scale (NPRS) was utilized for the measurement of pain and Oswestry Disability Index (ODI) for functional disability. Patients were assessed at baseline, at the end of 12th and 20 th week. Interventions were applied by the physical therapist having more than eight years of clinical experience for 10 weeks on alternate days. Results: LIPUS group reported greater reduction in pain with mean change of 3.18 points (95% CI: 2.2, 4.2; p < 0.001) at 12 th week, 6.18 points (95% CI: 5.5, 6.8; p < 0.001) at 20th week follow-up and functional disability with mean change of 28.24 points (95% CI: 23.7, 36 32.8; p < 0.001) at 12th week and 39.47 points (95% CI: 31.8, 47.1; p < 0.001) at 20th week follow-up compared with the RPT group.Conclusion: Low-intensity pulsed ultrasound has significantly reduced pain and functional disability in patients with early-stage lumbar spondylolysis and could be preferred as a safe non-invasive treatment method for early bone healing. Trial registration: WHO-Iranian registry of clinical trials (IRCT20200206046396N1, Dated: 02/05/2020).

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