Effects of selective decontamination of digestive tract on mortality and antibiotic resistance in the intensive-care unit

2005 ◽  
Vol 11 (2) ◽  
pp. 144-149 ◽  
Author(s):  
Evert de Jonge
Keyword(s):  
Intensive Care Unit ◽  
Antibiotic Resistance ◽  
Intensive Care ◽  
Digestive Tract ◽  
Selective Decontamination

scholarly journals Statistical Analysis Plan for the Selective Decontamination of the Digestive Tract in Intensive Care Unit (SuDDICU) study

2020 ◽  
Author(s):  
Laurent Billot ◽  
John Myburgh ◽  
Fiona Goodman ◽  
Simon Finfer ◽  
Ian Seppelt ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Statistical Analysis ◽  
Digestive Tract ◽  
Controlled Trial ◽  
Cluster Randomised Controlled Trial ◽  
Statistical Analysis Plan ◽  
Selective Decontamination ◽  
Cluster Randomised ◽  
Randomised Controlled

SuDDICU is an international, multicentre, cross-over, cluster randomised controlled trial comparing the effect of selective decontamination of the digestive tract to usual care on hospital mortality in patients receiving mechanical ventilation in the intensive care unit. This manuscript presents the pre-specified statistical analysis plan (SAP) for the SuDDICU trial. The SAP was written without knowledge of the effect of the intervention.

scholarly journals SuDDICU Protocol

2021 ◽  
Author(s):  
Laurent Billot ◽  
Brian Cuthbertson ◽  
Simon Finfer ◽  
Fiona Goodman ◽  
Anthony Gordon ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Randomised Controlled Trial ◽  
Digestive Tract ◽  
Controlled Trial ◽  
Cluster Randomised Controlled Trial ◽  
Selective Decontamination ◽  
Cluster Randomised ◽  
Randomised Controlled

Protocol for a crossover, cluster randomised controlled trial of Selective Decontamination of the Digestive Tract in Intensive Care Unit patients.

scholarly journals Selective decontamination of the digestive tract in intensive care

1992 ◽  
Vol 109 (3) ◽  
pp. 337-347 ◽  
Author(s):  
S. J. Boom ◽  
G. Ramsay
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Gastrointestinal Tract ◽  
Nosocomial Infection ◽  
Digestive Tract ◽  
Meta Analysis ◽  
Selective Decontamination ◽  
Absolute Difference ◽  
Gram Negative ◽  
The Impact

SUMMARYNosocomial infection in intensive care unit (ICU) practice is a common problem and is associated with abnormal carriage of Gram-negative aerobic bacilli in the gastrointestinal tract, resulting in endogenous infections. Selective decontamination of the digestive tract (SDD) is a regimen aimed at preventing or eradicating this abnormal carriage.A large number of trials examining SDD in ICU practice have been published, the vast majority showing a significant reduction in the incidence of nosocomial, Gram-negative infection. However, the impact on morbidity and mortality is much less certain. A recent meta-analysis has suggested a 10–20% reduction in mortality (3–6% absolute difference) with SDD. A discussion of these results is presented together with potential criticisms of SDD.

scholarly journals Emergence of multidrug-resistant Gram-negative bacteria during selective decontamination of the digestive tract on an intensive care unit—authors' response

2007 ◽  
Vol 60 (2) ◽  
pp. 446-446
Author(s):  
Nashwan al Naiemi ◽  
Edou R. Heddema ◽  
Aldert Bart ◽  
Evert de Jonge ◽  
Christina M. Vandenbroucke-Grauls ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Digestive Tract ◽  
Multidrug Resistant ◽  
Selective Decontamination ◽  
Gram Negative Bacteria ◽  
Gram Negative
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