Epithelial Ovarian Cancer and Low Malignant Potential (LMP) Tumors Associated With a Lower Incidence of Second Primary Breast Cancer

2007 ◽  
Vol 30 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Mark I. Hunter ◽  
Argyios Ziogas ◽  
Francisca Flores ◽  
Wendy R. Brewster
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Lower Incidence ◽  
Primary Breast Cancer ◽  
Malignant Potential ◽  
Second Primary ◽  
Low Malignant Potential ◽  
Lmp Tumors

Risk of second primary breast cancer among women with epithelial ovarian cancer compared to fallopian tube cancer

2014 ◽  
Vol 133 ◽  
pp. 101-102
Author(s):  
J.A. Rauh-Hain ◽  
J.T. Clemmer ◽  
R.M. Clark ◽  
T.R. Hall ◽  
W.B. Growdon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Primary Breast Cancer ◽  
Second Primary ◽  
Fallopian Tube Cancer

scholarly journals Declining Second Primary Ovarian Cancer After First Primary Breast Cancer

2013 ◽  
Vol 31 (6) ◽  
pp. 738-743 ◽  
Author(s):  
Sara J. Schonfeld ◽  
Amy Berrington de Gonzalez ◽  
Kala Visvanathan ◽  
Ruth M. Pfeiffer ◽  
William F. Anderson
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Primary Breast Cancer ◽  
Incidence Rates ◽  
Second Primary ◽  
Entire Study Period ◽  
Entire Study ◽  
Primary Ovarian Cancer ◽  
Ovarian Cancers ◽  
Er Expression

Purpose Although ovarian cancer incidence rates have declined in the United States, less is known of ovarian cancer trends among survivors of breast cancer. Therefore, we examined second primary ovarian cancers after first primary breast cancer. Methods Data were obtained from the Surveillance, Epidemiology, and End Results program (1973 to 2008). Standardized incidence ratios (SIRs) were calculated as the observed numbers of ovarian cancers among survivors of breast cancer compared with the expected numbers in the general population. Absolute rates were measured as the incidence rates for second primary ovarian cancer by year of diagnosis of the first primary breast cancer adjusted for age of breast cancer diagnosis and years since diagnosis. Results SIRs for second primary ovarian cancer were elevated over the entire study period (SIR, 1.24; 95% CI, 1.2 to 1.3), whereas the absolute rates declined with an estimated annual percentage change near 1% (−1.34% to −0.09% per year). Secular trends for second ovarian cancers were similar after estrogen receptor (ER) –positive and ER-negative breast cancers, whereas the age-specific patterns varied significantly by ER expression (P for interaction < .001). The largest SIR was among women age less than 50 years with ER-negative breast cancer (SIR, 4.35; 95% CI, 3.5 to 5.4). Conclusion Persistently elevated SIRs along with decreasing absolute rates over the entire study period suggest that ovarian cancers in both the general population and survivors of breast cancer are declining in parallel, possibly because of common risk factor exposures. Analytic studies are needed to further assess the parallel overall trends and the age-specific interaction by ER expression.

Nuclear cyclin B1 is overexpressed in low-malignant-potential ovarian tumors but not in epithelial ovarian cancer

2009 ◽  
Vol 201 (4) ◽  
pp. 367.e1-367.e6 ◽  
Author(s):  
Hong Zheng ◽  
Wei Hu ◽  
Michael T. Deavers ◽  
De-Yu Shen ◽  
Siqing Fu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cyclin B1 ◽  
Malignant Potential ◽  
Ovarian Tumors ◽  
Low Malignant Potential

scholarly journals Characteristics of Second Primary Breast Cancer after Ovarian Cancer: A Korea Central Cancer Registry retrospective study

2021 ◽  
Author(s):  
Eun-Gyeong Lee ◽  
Jiwon Lim ◽  
Hyeong In Ha ◽  
Myong Cheol Lim ◽  
Yoon Jung Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Cancer Patients ◽  
Cancer Registry ◽  
Primary Breast Cancer ◽  
Older Age ◽  
Second Primary ◽  
Advanced Stage ◽  
To Receive ◽  
Central Cancer Registry

Abstract Background: Second primary cancer has become an important issue among cancer survivors. This study sought to determine the differences in clinicopathologic outcomes between second primary breast cancer (SPBC) after ovarian cancer and primary breast cancer (PBC) in Korea.Methods: We searched the Korea Central Cancer Registry and identified 251,244 breast cancer cases that were diagnosed between 1999 and 2017. Demographic and clinical characteristics and overall survival (OS) rates were estimated according to age, histological type, and cancer stage.Results: Among the 228,329 patients included, 228,148 were patients with PBC and 181 were had SPBC, diagnosed after ovarian cancer (OC). The most common ages at diagnosis were 50‒59 years for SPBC and 40–49 years for PBC. Patients with SPBC were significantly less likely than patients with PBC to receive adjuvant radiotherapy (14.92% vs. 21.92%, p = 0.0228) or adjuvant chemotherapy (44.75% vs. 55.69%, p = 0.0031). Based on the age-standardized rate (ASR), the incidence of SPBC after OC was 293.58 per 100,000 ovarian patients and the incidence of PBC was 39.13 per 100,000 women. The 5-year OS rates were 72.88% and 89.37% for SPBC and PBC (p < 0.0001). The OS rate in SPBC decreased significantly with advanced stage and older age.Conclusion: The incidence of breast cancer is about 1.27 times higher in ovarian cancer patients than in healthy people. The survival outcomes were worse for SPBC than for PBC and were related to older age and advanced stage. Active screening for breast cancer is necessary in ovarian cancer patients.

scholarly journals Case series: Breast and ovarian cancer syndrome

2016 ◽  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Brca Mutation ◽  
Family Members ◽  
Case Series ◽  
Second Primary ◽  
Time Interval ◽  
Breast And Ovarian Cancer ◽  
Ovarian Carcinomas ◽  
Increased Risk

Aims and Objectives: To report a series of cases with breast and ovarian carcinomas either in same patient or in a family and identifying the importance of BRCA 1,2 genetic testing in such individuals. Materials and Methods: The medical records of breast and ovarian cancer patients operated over past 3 years at a single institute were reviewed retrospectively and their clinical profile, family history, final pathological reports and follow up data was collected. Results: 8 patients were found to have breast and ovarian malignancies, out of which 3 had synchronous breast and ovarian cancers, 4 had metachronous and 1 patient with ovarian cancer had history of breast cancer in family. Median age of presentation to the hospital was 47 years and median time interval in metachronous disease patients was 5.5 years. Conclusion: About 5% of people who have breast cancer and about 10% of women who have ovarian cancer have HBOC, caused by germline mutation in BRCA1, 2 gene. These individuals have increased risk of developing breast cancer at younger age, TNBC, or developing a second primary in breast or ovary plus an overall risk of breast/ovarian/prostate/pancreatic malignancies in other family members due to inheritable mutation. Identification of BRCA mutation in such individuals can help family members to undergo genetic counseling and follow different screening and prevention guidelines from general population thus reducing the cancer risks.

scholarly journals Second primary breast cancer in BRCA1 and BRCA2 mutation carriers: 10-year cumulative incidence in the Breast Cancer Family Registry

2015 ◽  
Vol 151 (3) ◽  
pp. 653-660 ◽  
Author(s):  
Tehillah S. Menes ◽  
Mary Beth Terry ◽  
David Goldgar ◽  
Irene L. Andrulis ◽  
Julia A. Knight ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cumulative Incidence ◽  
Primary Breast Cancer ◽  
Brca2 Mutation ◽  
Second Primary ◽  
Brca1 And Brca2 ◽  
Breast Cancer Family ◽  
Cancer Family ◽  
Mutation Carriers

Case of second primary breast cancer in ectopic breast tissue and review of the literature

2021 ◽  
Vol 14 (4) ◽  
pp. e241361
Author(s):  
Jamin Kweku Addae ◽  
Thomas Genuit ◽  
Joseph Colletta ◽  
Kathy Schilling
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Breast Tissue ◽  
Delayed Diagnosis ◽  
Left Breast ◽  
Second Primary ◽  
Female Population ◽  
Accessory Breast ◽  
History Of ◽  
High Index Of Suspicion

Accessory breast tissue (ABT) is found in approximately 2%–6% of the female population and are subject to most of the physiological and pathological changes that occur in pectoral breast. Primary breast cancer occurring in ABT is a rare occurrence and a second primary breast cancer occurring in an accessory breast has never been reported. We report the case of a 60-year-old woman with a history of mastectomy for left breast cancer 5 years prior to presentation, who presented with an enlarging right axilla mass found to be a second primary breast cancer in an accessory tissue on biopsy. Many physicians are unfamiliar with the clinical presentation of accessory breast cancer due to the rarity of the condition and this ultimately results in delayed diagnosis and advanced disease at presentation. It is therefore prudent that physicians have a high index of suspicion when patients present with axillary masses.

scholarly journals Second primary breast cancer

BMJ ◽  
1988 ◽  
Vol 296 (6639) ◽  
pp. 1755-1756 ◽  
Author(s):  
O Eremin
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Second Primary
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