Characteristics of Second Primary Breast Cancer after Ovarian Cancer: A Korea Central Cancer Registry retrospective study

Abstract Background: Second primary cancer has become an important issue among cancer survivors. This study sought to determine the differences in clinicopathologic outcomes between second primary breast cancer (SPBC) after ovarian cancer and primary breast cancer (PBC) in Korea.Methods: We searched the Korea Central Cancer Registry and identified 251,244 breast cancer cases that were diagnosed between 1999 and 2017. Demographic and clinical characteristics and overall survival (OS) rates were estimated according to age, histological type, and cancer stage.Results: Among the 228,329 patients included, 228,148 were patients with PBC and 181 were had SPBC, diagnosed after ovarian cancer (OC). The most common ages at diagnosis were 50‒59 years for SPBC and 40–49 years for PBC. Patients with SPBC were significantly less likely than patients with PBC to receive adjuvant radiotherapy (14.92% vs. 21.92%, p = 0.0228) or adjuvant chemotherapy (44.75% vs. 55.69%, p = 0.0031). Based on the age-standardized rate (ASR), the incidence of SPBC after OC was 293.58 per 100,000 ovarian patients and the incidence of PBC was 39.13 per 100,000 women. The 5-year OS rates were 72.88% and 89.37% for SPBC and PBC (p < 0.0001). The OS rate in SPBC decreased significantly with advanced stage and older age.Conclusion: The incidence of breast cancer is about 1.27 times higher in ovarian cancer patients than in healthy people. The survival outcomes were worse for SPBC than for PBC and were related to older age and advanced stage. Active screening for breast cancer is necessary in ovarian cancer patients.

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Comparing the Characteristics and Outcomes of Male and Female Breast Cancer Patients in Korea: Korea Central Cancer Registry

Cancer Research and Treatment ◽

10.4143/crt.2019.639 ◽

2020 ◽

Vol 52 (3) ◽

pp. 739-746

Author(s):

Eun-Gyeong Lee ◽

So-Youn Jung ◽

Myong Cheol Lim ◽

Jiwon Lim ◽

Han-Sung Kang ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Registry ◽

Female Breast Cancer ◽

Older Age ◽

Survival Outcomes ◽

Histological Types ◽

Female Breast ◽

Male Patients ◽

To Receive ◽

Central Cancer Registry

PurposeThis study aimed to determine the incidence of male breast cancer (MBC) and its survival outcomes in Korea, and to compare these results to those for female breast cancer (FBC).Materials and MethodsWe searched the Korea Central Cancer Registry and identified 227,122 breast cancer cases that were diagnosed between 1999 and 2016. Demographic and clinical characteristics and overall survival (OS) rates were estimated according to sex, age, histological type, and cancer stage.ResultsThe 227,122 patients included 1,094 MBC cases and 226,028 FBC cases. Based on the age-standardized rate, the male: female ratio was 0.0055:1. The most common ages at diagnosis were 60-69 years for MBC and 40-49 years for FBC (p < 0.001). Male patients were less likely than female patients to receive adjuvant radiotherapy (7.5% vs. 21.8%, p < 0.001) or adjuvant chemotherapy (40.1% vs. 55.4%, p < 0.001). The 5-year OS rates after diagnosis were 88.8% for all patients, although it was significantly lower for MBC than for FBC (76.2% vs. 88.9%, p < 0.001). In both groups, older age (≥ 60 years) was associated with shorter survival. The 5-year OS rates for the invasive histological types were 75.8% for men and 89.0% for women. The 5-year OS rates in both groups decreased with increasing cancer stage.ConclusionMBC was diagnosed at older ages than FBC, and male patients were less likely to receive radiotherapy and chemotherapy. The survival outcomes were worse for MBC than for FBC, with even poorer outcomes related to older age, the inflammatory histological types, and advanced stage. It is important that clinicians recognize the differences between FBC and MBC when treating these patients.

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Analysis of the tumor characteristics in young age breast cancer patients using collaborative stage data of the Korea Central Cancer Registry

Breast Cancer Research and Treatment ◽

10.1007/s10549-021-06107-9 ◽

2021 ◽

Author(s):

Junyup Kim ◽

Seri Hong ◽

Jae Jun Lee ◽

Young-Joo Won ◽

Eun Sook Lee ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Cancer Registry ◽

Young Age ◽

Tumor Characteristics ◽

Breast Cancer Patients ◽

Central Cancer Registry

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Abstract PS6-10: Risk estimation of locoregional recurrence, distant metastasis and second primary breast cancer in early stage breast cancer patients: The INFLUENCE 2.0 nomogram

10.1158/1538-7445.sabcs20-ps6-10 ◽

2021 ◽

Author(s):

Sabine Siesling ◽

Vinzenz Völkel ◽

Tom Hueting ◽

Teresa Draeger ◽

Marissa C van Maaren ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Distant Metastasis ◽

Primary Breast Cancer ◽

Locoregional Recurrence ◽

Early Stage ◽

Risk Estimation ◽

Early Stage Breast Cancer ◽

Second Primary ◽

Breast Cancer Patients

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Declining Second Primary Ovarian Cancer After First Primary Breast Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2012.43.2757 ◽

2013 ◽

Vol 31 (6) ◽

pp. 738-743 ◽

Cited By ~ 7

Author(s):

Sara J. Schonfeld ◽

Amy Berrington de Gonzalez ◽

Kala Visvanathan ◽

Ruth M. Pfeiffer ◽

William F. Anderson

Keyword(s):

Breast Cancer ◽

Ovarian Cancer ◽

Primary Breast Cancer ◽

Incidence Rates ◽

Second Primary ◽

Entire Study Period ◽

Entire Study ◽

Primary Ovarian Cancer ◽

Ovarian Cancers ◽

Er Expression

Purpose Although ovarian cancer incidence rates have declined in the United States, less is known of ovarian cancer trends among survivors of breast cancer. Therefore, we examined second primary ovarian cancers after first primary breast cancer. Methods Data were obtained from the Surveillance, Epidemiology, and End Results program (1973 to 2008). Standardized incidence ratios (SIRs) were calculated as the observed numbers of ovarian cancers among survivors of breast cancer compared with the expected numbers in the general population. Absolute rates were measured as the incidence rates for second primary ovarian cancer by year of diagnosis of the first primary breast cancer adjusted for age of breast cancer diagnosis and years since diagnosis. Results SIRs for second primary ovarian cancer were elevated over the entire study period (SIR, 1.24; 95% CI, 1.2 to 1.3), whereas the absolute rates declined with an estimated annual percentage change near 1% (−1.34% to −0.09% per year). Secular trends for second ovarian cancers were similar after estrogen receptor (ER) –positive and ER-negative breast cancers, whereas the age-specific patterns varied significantly by ER expression (P for interaction < .001). The largest SIR was among women age less than 50 years with ER-negative breast cancer (SIR, 4.35; 95% CI, 3.5 to 5.4). Conclusion Persistently elevated SIRs along with decreasing absolute rates over the entire study period suggest that ovarian cancers in both the general population and survivors of breast cancer are declining in parallel, possibly because of common risk factor exposures. Analytic studies are needed to further assess the parallel overall trends and the age-specific interaction by ER expression.

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