Birth Order, Sibship Size, and Risk for Germ-Cell Testicular Cancer

Epidemiology ◽  
2004 ◽  
Vol 15 (3) ◽  
pp. 323-329 ◽  
Author(s):  
Lorenzo Richiardi ◽  
Olof Akre ◽  
Mats Lambe ◽  
Fredrik Granath ◽  
Scott M. Montgomery ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Birth Order ◽  
Sibship Size

Sonographic Diagnosis of Unilateral Synchronous Testicular Tumors

2019 ◽  
Vol 2 ◽  
pp. 2
Author(s):  
Allison Forrest ◽  
Numbereye Numbere ◽  
Jerome Jean-Gilles ◽  
Thomas Frye ◽  
Vikram Dogra
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Histological Type ◽  
Synchronous Tumors ◽  
Testicular Tumors ◽  
Sonographic Diagnosis ◽  
Histological Types ◽  
Common Cancer

Testicular cancer accounts for 1% of all male cancers yet is the most common cancer affecting men aged 15–44 years. Most testicular cancers are seminomas or non-seminomatous germ cell tumors. Rarely, multiple testicular cancers may occur simultaneously, most often of the same histological type. However, synchronous tumors of different histological types may occur, although rarely. In this case study, we present the sonographic features with histopathologic correlation in a case of unilateral synchronous testicular tumors of discordant histology.

scholarly journals The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1325
Author(s):  
Abhisek Ghosh ◽  
Korsuk Sirinukunwattana ◽  
Nasullah Khalid Alham ◽  
Lisa Browning ◽  
Richard Colling ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Testicular Cancer ◽  
Germ Cell ◽  
Lymphovascular Invasion ◽  
Automatic Segmentation ◽  
Prognostic Significance ◽  
Germ Cell Tumours ◽  
Testicular Germ Cell ◽  
Testicular Germ Cell Tumours ◽  
Whole Slide Images

Testicular cancer is the most common cancer in men aged from 15 to 34 years. Lymphovascular invasion refers to the presence of tumours within endothelial-lined lymphatic or vascular channels, and has been shown to have prognostic significance in testicular germ cell tumours. In non-seminomatous tumours, lymphovascular invasion is the most powerful prognostic factor for stage 1 disease. For the pathologist, searching multiple slides for lymphovascular invasion can be highly time-consuming. The aim of this retrospective study was to develop and assess an artificial intelligence algorithm that can identify areas suspicious for lymphovascular invasion in histological digital whole slide images. Areas of possible lymphovascular invasion were annotated in a total of 184 whole slide images of haematoxylin and eosin (H&E) stained tissue from 19 patients with testicular germ cell tumours, including a mixture of seminoma and non-seminomatous cases. Following consensus review by specialist uropathologists, we trained a deep learning classifier for automatic segmentation of areas suspicious for lymphovascular invasion. The classifier identified 34 areas within a validation set of 118 whole slide images from 10 patients, each of which was reviewed by three expert pathologists to form a majority consensus. The precision was 0.68 for areas which were considered to be appropriate to flag, and 0.56 for areas considered to be definite lymphovascular invasion. An artificial intelligence tool which highlights areas of possible lymphovascular invasion to reporting pathologists, who then make a final judgement on its presence or absence, has been demonstrated as feasible in this proof-of-concept study. Further development is required before clinical deployment.

Impaired Testicular Function in Patients With Carcinoma-In-Situ of the Testis

1999 ◽  
Vol 17 (1) ◽  
pp. 173-173 ◽  
Author(s):  
Peter Meidahl Petersen ◽  
Aleksander Giwercman ◽  
Steen W. Hansen ◽  
Jørgen G. Berthelsen ◽  
Gedske Daugaard ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Leydig Cell ◽  
Carcinoma In Situ ◽  
Cell Function ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Testicular Dysfunction ◽  
Leydig Cell Function

PURPOSE: To elucidate the biologic association between germ cell neoplasia and testicular dysfunction, through investigation of Leydig cell function and semen quality in men with carcinoma-in-situ (CIS) of the testis. PATIENTS AND METHODS: We examined two groups of men, unilaterally orchidectomized for testicular cancer. Biopsy of the contralateral testis had showed CIS in a group of 24 patients and no evidence of CIS in the other group of 30 patients. Semen quality and serum levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were compared in these two groups of men after orchidectomy but before further treatment for testicular cancer. RESULTS: Significantly higher LH levels (median, 8.1 IU/L v 4.8 IU/L; P < .001) and generally lower testosterone levels (median, 12.5 nmol/L v 15.5 nmol/L; P = .13) were found in the CIS group. The proportion of patients with Leydig cell dysfunction was higher in the group of patients with CIS (11 of 24) than in the group of patients without (two of 30) (P = .01). Sperm concentration and total sperm count were significantly lower (P < .001) in patients with CIS (median, 0.03 × 106/mL and 0.10 × 106, respectively) than in patients without (median, 9.1 × 106/mL and 32 × 106, respectively), whereas the levels of FSH were significantly higher (P < .001) in the former group of men (median, 19.6 IU/L v 9.0 IU/L). CONCLUSION: Not only spermatogenesis but also Leydig cell function is impaired in testes with CIS. This impairment could be due to common factors in the pathogenesis of germ cell neoplasm and testicular dysfunction. Alternatively, CIS cells may have a negative impact on Leydig cell function.

Successful management of intracardiac extension of tumor thrombus in a patient with advanced nonseminomatous germ cell testicular cancer

Urology ◽  
1995 ◽  
Vol 46 (6) ◽  
pp. 883-887 ◽  
Author(s):  
Diane M.F. Savarese ◽  
Michael J. Rohrer ◽  
A. Thomas Pezzella ◽  
Ashley Davidoff ◽  
Armando E. Fraire ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Tumor Thrombus ◽  
Successful Management ◽  
Intracardiac Extension

Surgical management of low-stage nonseminomatous germ cell testicular cancer

2009 ◽  
Vol 104 (9b) ◽  
pp. 1362-1368 ◽  
Author(s):  
Andrew J. Stephenson ◽  
Eric A. Klein
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Surgical Management

scholarly journals The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred

2010 ◽  
Vol 28 (5) ◽  
pp. 492-499 ◽  
Author(s):  
Phuong L. Mai ◽  
Michael Friedlander ◽  
Kathy Tucker ◽  
Kelly-Anne Phillips ◽  
David Hogg ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Descriptive Analysis ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell

scholarly journals No evidence that middleborns feel less close to family and closer to friends than other birth orders.

2019 ◽  
Author(s):  
Veronika Simanko ◽  
Ben Rimmer ◽  
Thomas Victor Pollet
Keyword(s):  
Educational Attainment ◽  
Birth Order ◽  
Opposite Direction ◽  
Current Literature ◽  
Sibship Size ◽  
Emotional Closeness

Middleborns have been argued to be the neglected birth order. The present study aimed to test whether the emotional closeness to parents, siblings or friends differed between middleborns and otherborns, across two different datasets. Using a between family design this study accounted for gender, nationality, educational attainment, age and sibship size via matching. We found no evidence to suggest that middleborns differ from otherborns in familial sentiment. The sign of closeness to friends was in the opposite direction than predicted, with middleborns being less close than other birth orders. The findings are discussed with reference to current literature on birth order and familial sentiment.

Testicular tumours

2011 ◽  
pp. 1418-1426
Author(s):  
Olof Ståhl ◽  
Jakob Eberhard ◽  
Aleksander Giwercman
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Semen Quality ◽  
Cell Cancer ◽  
Germ Cell Cancer ◽  
High Risk Group ◽  
Point Of View ◽  
Testicular Function ◽  
Testicular Germ Cell ◽  
Sperm Dna Damage

Testicular cancer and the problems of male hypogonadism and infertility are closely related to each other—from a clinical as well as a biological point of view. Thus, men previously treated for testicular cancer are more and more frequently seen among patients referred to infertility clinics. This is due to the fact that: ◆ the survival rate among young testicular cancer patients is very high, being close to 95%, and the quality of life—including gonadal function—plays an important role in the men who have been cured ◆ there is an increasing knowledge that testicular function—both spermatogenesis and androgen production—in men with germ cell cancer is severely impaired. Recent research indicates a common prenatal cause of these pathologies of reproductive system ◆ modern techniques of assisted reproduction, particularly intracytoplasmic sperm injection (ICSI), have made it possible to obtain fertilization even when using ejaculates of extremely poor quality. This option has improved the possibility of cancer treated men becoming fathers. However, a source of potential worry is possible sperm DNA damage related to cancer and its treatment ◆ testicular germ cell cancer is more common in men presenting with poor semen quality. Thus, when investigating a man for infertility he should be assessed as to whether he belongs to a high-risk group for which a proper screening procedure should be offered (see below) Apart from this clinical link between testicular cancer and male infertility, there are also some indications of common biological factors involved in aetiology and pathogenesis. In this chapter some basic biological aspects of testicular cancer will be described. In Chapter 9.5.1 the hypothesis linking a rise of gonadal malignancy and poor testicular function is explained in more detail.

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