scholarly journals 108 THE FUNCTIONAL ROLE OF CA2+-ACTIVATED CL- CHANNEL CANDIDATES IN VASCULAR SMOOTH MUSCLE CELLS

2012 ◽  
Vol 30 ◽  
pp. e33
Author(s):  
Vibeke Secher Dam ◽  
Torbjarn Bragger ◽  
Donna Badtkjer ◽  
Christian Aalkjalr ◽  
Vladimir Matchkov
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Functional Role ◽  
Muscle Cells ◽  
Cl Channel

Functional role of stromal interaction molecule 1 (STIM1) in vascular smooth muscle cells

2007 ◽  
Vol 361 (4) ◽  
pp. 934-940 ◽  
Author(s):  
Yoichiro Takahashi ◽  
Hiroyuki Watanabe ◽  
Manabu Murakami ◽  
Kyoichi Ono ◽  
Yoshiko Munehisa ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Functional Role ◽  
Muscle Cells ◽  
Stromal Interaction Molecule 1

scholarly journals Effect of PGC-1αon Proliferation, Migration, and Transdifferentiation of Rat Vascular Smooth Muscle Cells Induced by High Glucose

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Xiaoqiang Qi ◽  
Yujing Zhang ◽  
Jing Li ◽  
Dongxia Hou ◽  
Yang Xiang
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
High Glucose ◽  
Muscle Cells ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene

We assessed the role of PGC-1α (PPARγ coactivator-1 alpha) in glucose-induced proliferation, migration, and inflammatory gene expression of vascular smooth muscle cells (VSMCs). We carried out phagocytosis studies to assess the role of PGC-1α in transdifferentiation of VSMCs by flow cytometry. We found that high glucose stimulated proliferation, migration and inflammatory gene expression of VSMCs, but overexpression of PGC-1α attenuated the effects of glucose. In addition, overexpression of PGC-1α decreased mRNA and protein level of VSMCs-related genes, and induced macrophage-related gene expression, as well as phagocytosis of VSMCs. Therefore, PGC-1α inhibited glucose-induced proliferation, migration and inflammatory gene expression of VSMCs, which are key features in the pathology of atherosclerosis. More importantly, PGC-1α transdifferentiated VSMCs to a macrophage-like state. Such transdifferentiation possibly increased the portion of VSMCs-derived foam cells in the plaque and favored plaque stability.

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