scholarly journals CIGARETTE SMOKE EXTRACT INDUCES DNA DAMAGE AND ACCELERATES CELLULAR SENESCENCE IN HUMAN ENDOTHELIAL CELLS

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e227
Author(s):  
Mari Ishida ◽  
Keitaro Ueda ◽  
Chiemi Sakai ◽  
Masao Yoshizumi ◽  
Takafumi Ishida
Keyword(s):  
Dna Damage ◽  
Endothelial Cells ◽  
Cigarette Smoke ◽  
Cellular Senescence ◽  
Cigarette Smoke Extract ◽  
Human Endothelial Cells

Protein carbonylation in human endothelial cells exposed to cigarette smoke extract

2013 ◽  
Vol 218 (2) ◽  
pp. 118-128 ◽  
Author(s):  
Rosalba Gornati ◽  
Graziano Colombo ◽  
Marco Clerici ◽  
Federica Rossi ◽  
Nicoletta Gagliano ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cigarette Smoke ◽  
Cigarette Smoke Extract ◽  
Protein Carbonylation ◽  
Human Endothelial Cells

scholarly journals EFFECT OF CIGARETTE SMOKE EXTRACT ON THE EXPRESSION OF THROMBOMODULIN IN HUMAN ENDOTHELIAL CELLS

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E311.2-E311
Author(s):  
Wei Yujie ◽  
Li Yi ◽  
Liu Huiliang
Keyword(s):  
Endothelial Cells ◽  
Cigarette Smoke ◽  
Cigarette Smoke Extract ◽  
Human Endothelial Cells

Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells

2009 ◽  
Vol 130 (3) ◽  
pp. 179-188 ◽  
Author(s):  
Kwang Seok Kim ◽  
Kyung Won Kang ◽  
Young Bae Seu ◽  
Suk-Hwan Baek ◽  
Jae-Ryong Kim
Keyword(s):  
Dna Damage ◽  
Endothelial Cells ◽  
Cellular Senescence ◽  
Interferon Γ ◽  
Human Endothelial Cells ◽  
Dna Damage Signaling

scholarly journals Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ashish Saxena ◽  
Matthew S. Walters ◽  
Jae-Hung Shieh ◽  
Ling-Bo Shen ◽  
Kazunori Gomi ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cigarette Smoke ◽  
Extracellular Vesicles ◽  
Basal Cell ◽  
Mapk Signaling ◽  
Cigarette Smoke Extract ◽  
Vegf Receptor ◽  
Vascular Endothelial ◽  
Basal Cells ◽  
Human Airway

AbstractThe human airway epithelium lining the bronchial tree contains basal cells that proliferate, differentiate, and communicate with other components of their microenvironment. One method that cells use for intercellular communication involves the secretion of exosomes and other extracellular vesicles (EVs). We isolated exosome-enriched EVs that were produced from an immortalized human airway basal cell line (BCi-NS1.1) and found that their secretion is increased by exposure to cigarette smoke extract, suggesting that this stress stimulates release of EVs which could affect signaling to other cells. We have previously shown that primary human airway basal cells secrete vascular endothelial growth factor A (VEGFA) which can activate MAPK signaling cascades in endothelial cells via VEGF receptor–2 (VEGFR2). Here, we show that exposure of endothelial cells to exosome-enriched airway basal cell EVs promotes the survival of these cells and that this effect also involves VEGFR2 activation and is, at least in part, mediated by VEGFA present in the EVs. These observations demonstrate that EVs are involved in the intercellular signaling between airway basal cells and the endothelium which we previously reported. The downstream signaling pathways involved may be distinct and specific to the EVs, however, as increased phosphorylation of Akt, STAT3, p44/42 MAPK, and p38 MAPK was not seen following exposure of endothelial cells to airway basal cell EVs.

Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells

2013 ◽  
Vol 90 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Kwang Seok Kim ◽  
Jung Eun Kim ◽  
Kyu Jin Choi ◽  
Sangwoo Bae ◽  
Dong Ho Kim
Keyword(s):  
Dna Damage ◽  
Endothelial Cells ◽  
Ionizing Radiation ◽  
Cellular Senescence

Cigarette smoke extract induces HO-1 expression in mouse cerebral vascular endothelial cells: Involvement of c-Src/NADPH oxidase/PDGFR/JAK2/STAT3 pathway

2010 ◽  
Vol 225 (3) ◽  
pp. 741-750 ◽  
Author(s):  
Ruey-Horng Shih ◽  
I-Ta Lee ◽  
Hsi-Lung Hsieh ◽  
Yu Ru Kou ◽  
Chuen-Mao Yang
Keyword(s):  
Endothelial Cells ◽  
Nadph Oxidase ◽  
Cigarette Smoke ◽  
Vascular Endothelial Cells ◽  
Cigarette Smoke Extract ◽  
Vascular Endothelial ◽  
Stat3 Pathway ◽  
Cerebral Vascular

scholarly journals Dynamics of heat shock protein 60 in endothelial cells exposed to cigarette smoke extract

2011 ◽  
Vol 51 (5) ◽  
pp. 777-780 ◽  
Author(s):  
Simone Barbara Kreutmayer ◽  
Barbara Messner ◽  
Michael Knoflach ◽  
Blair Henderson ◽  
Harald Niederegger ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cigarette Smoke ◽  
Cigarette Smoke Extract ◽  
Heat Shock Protein 60

scholarly journals DNA Damage in Human Endothelial Cells after Irradiation in Anoxia

1995 ◽  
Vol 34 (1) ◽  
pp. 111-116 ◽  
Author(s):  
Kerstin Rosander ◽  
Björn Zackrisson
Keyword(s):  
Dna Damage ◽  
Endothelial Cells ◽  
Human Endothelial Cells
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