Geographical variations of inflammatory bowel disease in France: A study based on national health insurance data

2006 ◽  
Vol 12 (3) ◽  
pp. 218-226 ◽  
Author(s):  
Virginie Nerich ◽  
Elisabeth Monnet ◽  
Arnaud Etienne ◽  
Samy Louafi ◽  
Cécile Ramée ◽  
...  
2011 ◽  
Vol 140 (5) ◽  
pp. S-267-S-268
Author(s):  
Antoine Racine ◽  
Aurelie Boutrelle ◽  
Alain Weill ◽  
Philippe Ricordeau ◽  
Marie-Christine Boutron-Ruault ◽  
...  

2018 ◽  
Vol 1 (21;1) ◽  
pp. E257-E277
Author(s):  
Chun-Hung Tseng

Background: Prior literatures have shown inflammatory bowel disease (IBD) could increase fibromyalgia (FM) risk. However, studies about gender and age distributions of FM risk among patients with IBD are rare. With large study samples, this study aimed to evaluate the FM risk among IBD patients with different gender and different age. Objective: We aim to estimate the FM risk among male and younger IBD patients with a large patient sample. Study Design: A retrospective cohort study was arranged in this research. Setting: The data used in this research were selected from the Taiwan National Health Insurance Research Database (NHIRD). Methods: From the Taiwan NHIRD, we selected 4,510 patients with IBD and 18,040 randomly gender- and age-matched patients without a history of IBD from the beginning of 2000 to the end of 2005 to analyze the development of FM over a 12-year follow-up period (2000– 2011). The Cox regression model was used to assess the effects of IBD on the risk of FM by adjusting for gender, age, and comorbidities, including hypertension, diabetes, hyperlipidemia, depression, anxiety, and sleep disorder. Results: After adjusting suitable covariates, the IBD patients had a greater FM risk (adjusted hazard ratio [aHR] 1.70, 95% confidence interval [CI] 1.59–1.83) than the controls. Male IBD patients had a higher FM risk than female IBD patients did (aHR 2.00, 95% CI 1.79–2.23 and aHR 1.52, 95% CI 1.38–1.67, respectively). The greatest age-specific FM risk occurred in the youngest IBD subgroup (≤ 39 years old) (aHR 1.92, 95% CI 1.68–2.19). Limitations: The information about personal behaviors was unobtainable in the Taiwan NHIRD. Other risk factors for cardiovascular disease that might augment FM cannot be excluded entirely in this study. Conclusion: IBD is disclosed to be correlated with an enhanced risk to develop FM, particularly in male and younger IBD patients. For preventing FM, it is necessary to pay more attention to the management of the IBD patients. Future researches are needed to further confirm the findings in this study. Key words: Inflammation, inflammatory bowel disease, fibromyalgia, Taiwan National Health Insurance Research Database


2012 ◽  
Vol 27 (3) ◽  
pp. 285 ◽  
Author(s):  
Seo-Young Lee ◽  
Ki-Young Jung ◽  
Il Keun Lee ◽  
Sang Do Yi ◽  
Yong Won Cho ◽  
...  

2020 ◽  
Author(s):  
Byoungjin Park ◽  
Yong-Jae Lee ◽  
Hye Sun Lee ◽  
Dong-Hyuk Jung

Abstract Background: Ischemic heart disease (IHD) without diabetes is considered an important challenge to human health and is associated with a poor prognosis as well as a lack of health awareness. Until now, the association between early insulin resistance and IHD among nondiabetic adults has been poorly understood. We prospectively investigated the relationship between the triglyceride-glucose (TyG) index, a surrogate marker of early insulin resistance, and incident IHD risk in a large cohort of nondiabetic adults using National Health Insurance data. Methods: We assessed 16,455 participants (8,426 men and 8,029 women) without diabetes using data from a health risk assessment study (HERAS) and Korea Health Insurance Review & Assessment (HIRA) data. The participants were divided into four groups according to TyG index quartiles, calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD, using multivariate Cox proportional-hazards regression models, over a 50-month period that followed the baseline survey.Results: During the follow-up period, 322 (2.0%) participants developed IHD. HRs of IHD for TyG index quartiles 1–4 were 1.00, 1.63 (95% CI, 1.06–2.49), 1.88 (95% CI, 1.23–2.87), and 2.35 (95% CI, 1.53–3.61), respectively, after adjusting for age, sex, body mass index, smoking status, alcohol intake, physical activity, high sensitivity C-reactive protein, and mean arterial blood pressure.Conclusion: A higher TyG index precedes and significantly predicts future IHD among nondiabetic Koreans. Accordingly, a high TyG index may be a useful additional measure in assessing cardiovascular risks for apparently healthy adults in clinical practice.


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