scholarly journals Relationship Between the Triglyceride-glucose Index and Incident Ischemic Heart Disease Risk: A Prospective Study Using National Health Insurance Data

2020 ◽  
Author(s):  
Byoungjin Park ◽  
Yong-Jae Lee ◽  
Hye Sun Lee ◽  
Dong-Hyuk Jung
Keyword(s):  
Insulin Resistance ◽  
Heart Disease ◽  
Health Insurance ◽  
Ischemic Heart Disease ◽  
National Health Insurance ◽  
National Health ◽  
Ischemic Heart ◽  
Health Insurance Data ◽  
Tyg Index ◽  
Insurance Data

Abstract Background: Ischemic heart disease (IHD) without diabetes is considered an important challenge to human health and is associated with a poor prognosis as well as a lack of health awareness. Until now, the association between early insulin resistance and IHD among nondiabetic adults has been poorly understood. We prospectively investigated the relationship between the triglyceride-glucose (TyG) index, a surrogate marker of early insulin resistance, and incident IHD risk in a large cohort of nondiabetic adults using National Health Insurance data. Methods: We assessed 16,455 participants (8,426 men and 8,029 women) without diabetes using data from a health risk assessment study (HERAS) and Korea Health Insurance Review & Assessment (HIRA) data. The participants were divided into four groups according to TyG index quartiles, calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD, using multivariate Cox proportional-hazards regression models, over a 50-month period that followed the baseline survey.Results: During the follow-up period, 322 (2.0%) participants developed IHD. HRs of IHD for TyG index quartiles 1–4 were 1.00, 1.63 (95% CI, 1.06–2.49), 1.88 (95% CI, 1.23–2.87), and 2.35 (95% CI, 1.53–3.61), respectively, after adjusting for age, sex, body mass index, smoking status, alcohol intake, physical activity, high sensitivity C-reactive protein, and mean arterial blood pressure.Conclusion: A higher TyG index precedes and significantly predicts future IHD among nondiabetic Koreans. Accordingly, a high TyG index may be a useful additional measure in assessing cardiovascular risks for apparently healthy adults in clinical practice.

scholarly journals Triglyceride to HDL-Cholesterol Ratio and the Incident Risk of Ischemic Heart Disease Among Koreans Without Diabetes: A Longitudinal Study Using National Health Insurance Data

2021 ◽  
Vol 8 ◽  
Author(s):  
Byoungjin Park ◽  
Dong Hyuk Jung ◽  
Hye Sun Lee ◽  
Yong Jae Lee
Keyword(s):  
Insulin Resistance ◽  
Heart Disease ◽  
Health Insurance ◽  
Ischemic Heart Disease ◽  
National Health Insurance ◽  
National Health ◽  
Hdl Cholesterol ◽  
Health Insurance Data ◽  
Cholesterol Ratio ◽  
Insurance Data

Background: Early insulin resistance without diabetes can cause cardiovascular disease, which is a public health challenge. This study aimed to investigate the effects of the triglyceride to high-density lipid (HDL)-cholesterol ratio (TG/HDL-C), which could reflect insulin resistance from the beginning, on the incident risk of ischemic heart disease (IHD).Methods: We assessed 16,455 individuals (8,426 men and 8,029 women) without diabetes in a community-dwelling Korean cohort using National Health Insurance data. Participants were classified based on the TG/HDL-C quartiles. Using multivariate Cox proportional-hazards regression models, we prospectively examined the hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD over 50 months after baseline enrolment.Results: During the follow-up period, 321 (2.0%) participants developed IHD. After adjusting for potential confounding variables, the HRs of IHD for TG/HDL-C quartiles were 1.00, 1.61 (95% CI, 1.05–2.48), 1.85 (95% CI, 1.21–2.81), and 2.29 (95% CI, 1.50–3.51), respectively. Compared with men, women showed higher HRs for the risk of incident IHD in the fourth quartile [HR (95% CI) = 2.98 [1.50–5.88] and 1.80 [1.02–3.17], respectively). Compared with metabolic syndrome, TG/HDL-C had a more powerful predictive value for IHD.Conclusions: In Koreans without diabetes, an increased TG/HDL-C precedes future IHD. Additionally, sex differences may merit serious consideration when interpreting TG/HDL-C for assessing cardiovascular risks in clinical practice.

scholarly journals Triglyceride to HDL-Cholesterol Ratio and the Incident Risk of Ischemic Heart Disease Among Koreans Without Diabetes: A Prospective Study Using National Health Insurance Data

2021 ◽  
Author(s):  
Byoungjin Park ◽  
Dong-Hyuk Jung ◽  
Hye Sun Lee ◽  
Yong-Jae Lee
Keyword(s):  
Insulin Resistance ◽  
Heart Disease ◽  
Health Insurance ◽  
Ischemic Heart Disease ◽  
National Health Insurance ◽  
National Health ◽  
Hdl Cholesterol ◽  
Health Insurance Data ◽  
Cholesterol Ratio ◽  
Insurance Data

Abstract Background Early insulin resistance without diabetes can cause cardiovascular disease, which is a public health challenge. This study aimed to investigate the longitudinal effects of the triglyceride to high-density lipid (HDL)-cholesterol ratio (TG/HDL-C), which could reflect insulin resistance from the beginning, on the incident risk of ischemic heart disease (IHD). Methods We assessed 16,455 individuals (8,426 men and 8,029 women) without diabetes in a community-dwelling Korean cohort using National Health Insurance data. Participants were classified based on the TG/HDL-C quartiles. Using multivariate Cox proportional-hazards regression models, we prospectively examined the hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD over 50 months after baseline enrolment. Results During the follow-up period, 321 (2.0%) participants developed IHD. After adjusting for potential confounding variables, the HRs of IHD for TG/HDL-C quartiles were 1.00, 1.61 (95% CI, 1.05–2.48), 1.85 (95% CI, 1.21–2.81), and 2.29 (95% CI, 1.50–3.51), respectively. Compared with men, women showed higher HRs for the risk of incident IHD in the fourth quartile [HR (95% CI) = 2.98 [1.50–5.88] and 1.80 [1.02–3.17], respectively). Compared with metabolic syndrome, TG/HDL-C had a more powerful predictive value for IHD. Conclusions In Koreans without diabetes, an increased TG/HDL-C precedes future IHD. Additionally, sex differences may merit serious consideration when interpreting TG/HDL-C for assessing cardiovascular risks in clinical practice.

scholarly journals The triglyceride-glucose index predicts ischemic heart disease risk in Koreans: a prospective study using National Health Insurance Service data

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Byoungjin Park ◽  
Yong-Jae Lee ◽  
Hye Sun Lee ◽  
Dong-Hyuk Jung
Keyword(s):  
Heart Disease ◽  
Health Insurance ◽  
Ischemic Heart Disease ◽  
National Health Insurance ◽  
National Health ◽  
Disease Risk ◽  
Surrogate Marker ◽  
Ischemic Heart ◽  
Tyg Index ◽  
Service Data

Abstract Background Ischemic heart disease (IHD) without diabetes is considered an important challenge to human health and is associated with a poor prognosis, as well as a lack of health awareness. We prospectively investigated the relationship between the triglyceride-glucose (TyG) index, a surrogate marker of early insulin resistance, and incident IHD risk in a large cohort of nondiabetic Korean adults using National Health Insurance Service data. Methods We assessed 16,455 participants (8426 men and 8029 women) without diabetes using data from a health risk assessment study (HERAS) and Korea Health Insurance Review and Assessment (HIRA) data. The participants were divided into four groups according to TyG index quartiles, calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional-hazards regression models over a 50-month period that followed the baseline survey. Results During the follow-up period, 322 (2.0%) participants developed IHD. HRs of IHD for TyG index quartiles 2–4 were 1.61 (95% CI 1.05–2.48), 1.85 (95% CI 1.21–2.81), and 2.29 (95% CI 1.50–3.51), respectively, after adjusting for age, sex, body mass index, smoking status, alcohol intake, and physical activity. Conclusions A higher TyG index precedes and significantly predicts future IHD among nondiabetic Koreans. Accordingly, the TyG index may be a useful measure in assessing cardiovascular risk for nondiabetic adults in the preclinical stage.

scholarly journals Predictive Factors on the Incidence of Heart Failure in Patients with Ischemic Heart Disease: Using a 10-Year Population-Based Korea National Health Insurance Cohort Data

2020 ◽  
Vol 17 (22) ◽  
pp. 8670
Author(s):  
Seon Young Hwang ◽  
Kyung Ae Kim ◽  
Oh Jong Choi
Keyword(s):  
Heart Failure ◽  
Heart Disease ◽  
Health Insurance ◽  
Ischemic Heart Disease ◽  
National Health Insurance ◽  
National Health ◽  
Ischemic Heart ◽  
Rank Test ◽  
Diabetic Patients ◽  
Men And Women

Early risk stratification and preventative strategies are required in patients with ischemic heart disease (IHD) to prevent heart failure (HF). We aimed to investigate the rate of progression to HF and to investigate the factors predicting the development of HF in a population with IHD for 10 years. A descriptive study was conducted using Korea National Health Insurance Service-National Sample Cohort (NHI-NSC) data (2005–2015). Among the patients diagnosed with IHD for the first time in 2005–2006, 2271 men and 2037 women who responded to the health check-up survey were finally selected. Cox Proportional Hazard regression analyses and the Kaplan–Meier survival analysis were used. HF incidence rates were 5.1% in men and 8.0% in women. The mean duration of transition to HF was 4.85 ± 2.73 years in men and 4.73 ± 2.73 years in women. The non-incidence rate of HF was higher in men than in women (Log-rank test, p = 0.0003). Bivariate analyses showed that older age, prevalence of hypertension and diabetes, less alcohol, and lower physical exercise were associated with the incidence of HF in both men and women. Multivariate analyses found that HF incidence in aged subjects ≥70 years was 1.46 times higher in men and 1.44 times higher in women compared to those in their 30 s (p < 0.001). Prevalence of hypertension reduced the incidence of HF by 0.78 and 0.87 for men and women, respectively. The prevalence of diabetes increased 1.23 times only in men. These findings suggest that special attention such as periodic counseling and education is needed to prevent progression to HF in elderly and diabetic patients during follow-up after IHD.

scholarly journals Prevalence of Treated Epilepsy in Korea Based on National Health Insurance Data

2012 ◽  
Vol 27 (3) ◽  
pp. 285 ◽  
Author(s):  
Seo-Young Lee ◽  
Ki-Young Jung ◽  
Il Keun Lee ◽  
Sang Do Yi ◽  
Yong Won Cho ◽  
...  
Keyword(s):  
Health Insurance ◽  
National Health Insurance ◽  
National Health ◽  
Health Insurance Data ◽  
Insurance Data
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