Protective Effect of Isoflurane Anesthesia on Noise-Induced Hearing Loss in Mice

2005 ◽  
Vol 115 (11) ◽  
pp. 1996-1999 ◽  
Author(s):  
Joung Uk Kim ◽  
Hyun Jung Lee ◽  
Hun Hee Kang ◽  
Jin Woo Shin ◽  
Seung Woo Ku ◽  
...  
2018 ◽  
Vol 275 (12) ◽  
pp. 2957-2966 ◽  
Author(s):  
Gülin Gökçen Kesici ◽  
Fatma Ceyda Akın Öcal ◽  
Seren Gülşen Gürgen ◽  
Şaban Remzi Erdem ◽  
Ersin Öğüş ◽  
...  

2005 ◽  
Vol 49 (4) ◽  
pp. 523
Author(s):  
Seung Woo Ku ◽  
Jin Woo Shin ◽  
Ji Yeon Lee ◽  
Joung Uk Kim ◽  
Su Keoung Lee ◽  
...  

2014 ◽  
Vol 16 (70) ◽  
pp. 149 ◽  
Author(s):  
Shi-Nae Park ◽  
Dong-Kee Kim ◽  
Yooyeon Park ◽  
Sang-A Back ◽  
HongLim Kim ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-11
Author(s):  
Min Soo Kim ◽  
SeongAe Kwak ◽  
Heumyoung Baek ◽  
Zewu Li ◽  
Seong-Kyu Choe ◽  
...  

Noise-induced hearing loss (NIHL) results from the damage of the delicate hair cells inside the ear after excessive stimulation of noise. Unlike certain lower animals such as amphibians, fishes, and birds, in humans, hair cells cannot be regenerated once they are killed or damaged; thus, there are no therapeutic options to cure NIHL. Therefore, it is more important to protect hair cells from the noise before the damage occurs. In this study, we report the protective effect of Yang Mi Ryung extract (YMRE) against NIHL; this novel therapeutic property of YMRE has not been reported previously. Our data demonstrates that the hearing ability damaged by noise is markedly restored in mice preadministrated with YMRE before noise exposure, to the level of normal control group. Our study also provides the molecular mechanism underlying the protective effect of YMRE against NIHL by showing that YMRE significantly blocks noise-induced apoptotic cell death and reduces reactive oxygen species (ROS) production in cochleae. Moreover, quantitative polymerase chain reaction (qPCR) analysis demonstrates that YMRE has anti-inflammatory properties, suppressing the mRNA levels of TNFα and IL-1β induced by noise exposure. In conclusion, YMRE could be a useful preventive intervention to prevent hearing impairment induced by the exposure to excessive noise.


2017 ◽  
Vol 1657 ◽  
pp. 95-100 ◽  
Author(s):  
Jian Wen ◽  
Na Duan ◽  
Qiang Wang ◽  
Gui-xia Jing ◽  
Ying Xiao

2004 ◽  
Vol 131 (2) ◽  
pp. P154-P154
Author(s):  
Jong W Chung ◽  
Joung Uk Kim ◽  
Hun Hee Kang ◽  
Hyun Jung Lee ◽  
Jeong-Su Woo

2013 ◽  
Vol 124 (5) ◽  
pp. E188-E193 ◽  
Author(s):  
Jian Wen ◽  
Ying Xiao ◽  
Yan-Xia Bai ◽  
Min Xu

2021 ◽  
Vol 2021 ◽  
pp. 1-2
Author(s):  
Min Soo Kim ◽  
SeongAe Kwak ◽  
Heumyoung Baek ◽  
Zewu Li ◽  
Seong-Kyu Choe ◽  
...  


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